Molecular modeling aided design of nicotinic acid receptor GPR109A agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 4963-4967

  Deng, Qiaolin ^a   Frie, Jessica L ^a   Marley, Daria M ^a   Beresis, Richard T ^a   Ren, Ning ^a   Cai, Tian Quan ^a   Taggart, Andrew K P ^a   Cheng, Kang ^a   Carballo Jane, Ester ^a   Wang, Junying ^a   Tong, Xinchun ^a   Waters, M Gerard ^a   Tata, James R ^a   Colletti, Steven L ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

GPR109A agonists; Homology modeling

Indexed keywords

ANTHRANILIC ACID DERIVATIVE; NICOTINIC ACID RECEPTOR GPR109A AGONIST; NICOTINIC AGENT; NICOTINIC RECEPTOR; RHODOPSIN; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG DESIGN; DRUG HALF LIFE; DRUG STRUCTURE; HIGH THROUGHPUT SCREENING; MOLECULAR MODEL; MOUSE; NONHUMAN; X RAY CRYSTALLOGRAPHY;

ANTHRANILIC ACIDS; BINDING SITES; COMBINATORIAL CHEMISTRY TECHNIQUES; HUMANS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NIACIN; NICOTINIC AGONISTS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NICOTINIC; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINAE;

EID: 51349163414     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.030     Document Type: Article

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