Discovery of a novel class of PPARδ partial agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 18, 2008, Pages 5018-5022

  Shearer, Barry G ^a   Patel, Hari S ^a   Billin, Andrew N ^a   Way, James M ^a   Winegar, Deborah A ^a   Lambert, Millard H ^a   Xu, Robert X ^a   Leesnitzer, Lisa M ^a   Merrihew, Raymond V ^a   Huet, Stephane ^b   Willson, Timothy M ^a  

^a GLAXOSMITHKLINE   (United States)

^b GLAXOSMITHKLINE   (France)

Author keywords

CPT1a; Partial agonist; PDK4; PPARd

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; [4 [2 (3 FLUORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 THIAZOLYLMETHYLTHIO] 2 METHYLPHENOXY]ACETIC ACID; ANTHRANILIC ACID; BVT 762; GSK 1115; GSK 7227; GW 1516; GW 9371; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; CPT1A GENE; DRUG DESIGN; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GENE; GENE TARGETING; HUMAN; HUMAN CELL; MUSCLE CELL; PDK4 GENE; SKELETAL MUSCLE; STRUCTURE ACTIVITY RELATION;

ANTHRANILIC ACIDS; CARNITINE O-PALMITOYLTRANSFERASE; COMBINATORIAL CHEMISTRY TECHNIQUES; CRYSTALLOGRAPHY, X-RAY; HUMANS; MOLECULAR STRUCTURE; PPAR DELTA; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAHYDROISOQUINOLINES;

EID: 51349105690     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.08.011     Document Type: Article

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