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Volumn 5, Issue 4, 2008, Pages 654-664

NMR spectroscopic evaluation of the internal environment of PLGA microspheres

Author keywords

Biodegradable polyesters; Macromolecular drug delivery; Polymeric drug systems; Solid state NMR spectroscopy; Stability

Indexed keywords

BUFFER; HISTIDINE; IMIDAZOLE; MICROSPHERE; PHOSPHATE; PHOSPHORIC ACID; POLYGLACTIN; POLYMER;

EID: 51049093810     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp7001522     Document Type: Conference Paper
Times cited : (6)

References (37)
  • 1
    • 2642677624 scopus 로고    scopus 로고
    • Improving Protein Therapeutics with Sustained-release Formulations
    • Putney, S. D.; Burke, P. A. Improving Protein Therapeutics with Sustained-release Formulations. Nat. Biotechnol. 1998, 16, 153-157.
    • (1998) Nat. Biotechnol , vol.16 , pp. 153-157
    • Putney, S.D.1    Burke, P.A.2
  • 2
    • 0041718431 scopus 로고    scopus 로고
    • Non-invasive In Vivo Characterization of Release Processes in Biodegradable Polymers by Low-frequency Electron Paramagnetic Resonance Spectroscopy
    • Mader, K.; Gallez, B.; Liu, K. J.; Swartz, H. M. Non-invasive In Vivo Characterization of Release Processes in Biodegradable Polymers by Low-frequency Electron Paramagnetic Resonance Spectroscopy. Biomaterials 1996, 17, 457-461.
    • (1996) Biomaterials , vol.17 , pp. 457-461
    • Mader, K.1    Gallez, B.2    Liu, K.J.3    Swartz, H.M.4
  • 3
    • 0030636181 scopus 로고    scopus 로고
    • Noninvasive In Vivo Monitoring of Drug Release and Polymer Erosion from Biodegradable Polymers by EPR Spectroscopy and NMR Imaging
    • Mader, K.; Bacic, G.; Domb, A.; Elmalak, O.; Langer, R.; Swartz, H. M. Noninvasive In Vivo Monitoring of Drug Release and Polymer Erosion from Biodegradable Polymers by EPR Spectroscopy and NMR Imaging. J. Pharm. Sci. 1997, 86, 126-134.
    • (1997) J. Pharm. Sci , vol.86 , pp. 126-134
    • Mader, K.1    Bacic, G.2    Domb, A.3    Elmalak, O.4    Langer, R.5    Swartz, H.M.6
  • 4
    • 0031751359 scopus 로고    scopus 로고
    • Monitoring Microviscosity and Microacidity of the Albumin Microenvironment Inside Degrading Microparticles from Poly(lactide-co-glycolide) (PLG) or ABA-triblock Polymers Containing Hydrophobic Poly(lactide-co-glycolide) A Blocks and Hydrophilic Poly(ethyleneoxide) B Blocks
    • Mader, K.; Bittner, B.; Li, Y. X.; Wohlauf, W.; Kissel, T. Monitoring Microviscosity and Microacidity of the Albumin Microenvironment Inside Degrading Microparticles from Poly(lactide-co-glycolide) (PLG) or ABA-triblock Polymers Containing Hydrophobic Poly(lactide-co-glycolide) A Blocks and Hydrophilic Poly(ethyleneoxide) B Blocks. Pharm. Res. 1998, 15, 787-793.
    • (1998) Pharm. Res , vol.15 , pp. 787-793
    • Mader, K.1    Bittner, B.2    Li, Y.X.3    Wohlauf, W.4    Kissel, T.5
  • 5
    • 0034006495 scopus 로고    scopus 로고
    • Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres
    • Fu, K.; Pack, D. W.; Klibanov, A. M.; Langer, R. Visual Evidence of Acidic Environment Within Degrading Poly(lactic-co-glycolic acid) (PLGA) Microspheres. Pharm. Res. 2000, 17, 100-106.
    • (2000) Pharm. Res , vol.17 , pp. 100-106
    • Fu, K.1    Pack, D.W.2    Klibanov, A.M.3    Langer, R.4
  • 6
    • 10044272241 scopus 로고    scopus 로고
    • Mapping Neutral Microclimate pH in PLGA Microspheres
    • Li, L.; Schwendeman, S. P. Mapping Neutral Microclimate pH in PLGA Microspheres. J. Controlled Release 2005, 101 (1-3 Special Issue), 163-173.
    • (2005) J. Controlled Release , vol.101 , Issue.1 -3 SPECIAL ISSUE , pp. 163-173
    • Li, L.1    Schwendeman, S.P.2
  • 7
    • 0033043628 scopus 로고    scopus 로고
    • The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes Camptothecins
    • Shenderova, A.; Burke, T. G.; Schwendeman, S. P. The Acidic Microclimate in Poly(lactide-co-glycolide) Microspheres Stabilizes Camptothecins. Pharm. Res. 1999, 16, 241-248.
    • (1999) Pharm. Res , vol.16 , pp. 241-248
    • Shenderova, A.1    Burke, T.G.2    Schwendeman, S.P.3
  • 8
    • 33846799405 scopus 로고    scopus 로고
    • Effect of Excipients on PLGA Film Degradation and the Stability of an Incorporated Peptide
    • Houchin, M. L.; Neuenswander, S. A.; Topp, E. M. Effect of Excipients on PLGA Film Degradation and the Stability of an Incorporated Peptide. J. Controlled Release 2007, 117 (3), 413-420.
    • (2007) J. Controlled Release , vol.117 , Issue.3 , pp. 413-420
    • Houchin, M.L.1    Neuenswander, S.A.2    Topp, E.M.3
  • 9
    • 11444264292 scopus 로고    scopus 로고
    • Potentiometric Method for Determination of Microclimate pH in Poly(lactic-co-glycolic acid) Films
    • Shenderova, A.; Ding, A. G.; Schwendeman, S. P. Potentiometric Method for Determination of Microclimate pH in Poly(lactic-co-glycolic acid) Films. Macromolecules 2004, 37 (26), 10052-10058.
    • (2004) Macromolecules , vol.37 , Issue.26 , pp. 10052-10058
    • Shenderova, A.1    Ding, A.G.2    Schwendeman, S.P.3
  • 10
    • 33646443088 scopus 로고    scopus 로고
    • Prediction of Microclimate pH in Poly(lactic-co-glycolic acid) Films
    • Ding, A. G.; Shenderova, A.; Schwendeman, S. P. Prediction of Microclimate pH in Poly(lactic-co-glycolic acid) Films. J. Am. Chem. Soc. 2006, 128, 5384-5390.
    • (2006) J. Am. Chem. Soc , vol.128 , pp. 5384-5390
    • Ding, A.G.1    Shenderova, A.2    Schwendeman, S.P.3
  • 11
    • 0036000111 scopus 로고    scopus 로고
    • Recent Advances in the Stabilization of Proteins Encapsulated in Injectable PLGA Delivery Systems
    • Schwendeman, S. P. Recent Advances in the Stabilization of Proteins Encapsulated in Injectable PLGA Delivery Systems. Crit. Rev. Ther. Drug Carrier Syst. 2002, 19, 73-98.
    • (2002) Crit. Rev. Ther. Drug Carrier Syst , vol.19 , pp. 73-98
    • Schwendeman, S.P.1
  • 12
    • 0033986610 scopus 로고    scopus 로고
    • Stabilization of Proteins Encapsulated in Injectable Poly (lactide-co-glycolide)
    • Zhu, G. Z.; Mallery, S. R.; Schwendeman, S. P. Stabilization of Proteins Encapsulated in Injectable Poly (lactide-co-glycolide). Nat. Biotechnol. 2000, 18, 52-57.
    • (2000) Nat. Biotechnol , vol.18 , pp. 52-57
    • Zhu, G.Z.1    Mallery, S.R.2    Schwendeman, S.P.3
  • 15
    • 0029071504 scopus 로고
    • Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin - Effect of Moisture and Stabilization by Excipients
    • Costantino, H. R.; Langer, R.; Klibanov, A. M. Aggregation of a Lyophilized Pharmaceutical Protein, Recombinant Human Albumin - Effect of Moisture and Stabilization by Excipients. Bio-Technology 1995, 13, 493-496.
    • (1995) Bio-Technology , vol.13 , pp. 493-496
    • Costantino, H.R.1    Langer, R.2    Klibanov, A.M.3
  • 16
    • 0028333271 scopus 로고
    • Importance of Distinct Water Environments in the Hydrolysis of Poly(DL-lactide-co-glycolide)
    • Schmitt, E. A.; Flanagan, D. R.; Linhardt, R. J. Importance of Distinct Water Environments in the Hydrolysis of Poly(DL-lactide-co-glycolide). Macromolecules 1994, 27, 743-748.
    • (1994) Macromolecules , vol.27 , pp. 743-748
    • Schmitt, E.A.1    Flanagan, D.R.2    Linhardt, R.J.3
  • 17
    • 33745926826 scopus 로고    scopus 로고
    • Investigation of Solid-state NMR Line Widths of Ibuprofen in Drug Formulations
    • Barich, D. H.; Davis, J. M.; Schieber, L. J.; Zell, M. T.; Munson, E. J. Investigation of Solid-state NMR Line Widths of Ibuprofen in Drug Formulations. J. Pharm. Sci. 2006, 95, 1586-1594.
    • (2006) J. Pharm. Sci , vol.95 , pp. 1586-1594
    • Barich, D.H.1    Davis, J.M.2    Schieber, L.J.3    Zell, M.T.4    Munson, E.J.5
  • 19
    • 18744374968 scopus 로고    scopus 로고
    • Sheth, A. R.; Lubach, J. W.; Munson, E. J.; Muller, F. X.; Grant, D. J. W. Mechanochromism of Piroxicam Accompanied by Intermolecular Proton Transfer Probed by Spectroscopic Methods and Solid-phase Changes. J. Am. Chem. Soc. 2005, 127, 6641-6651.
    • Sheth, A. R.; Lubach, J. W.; Munson, E. J.; Muller, F. X.; Grant, D. J. W. Mechanochromism of Piroxicam Accompanied by Intermolecular Proton Transfer Probed by Spectroscopic Methods and Solid-phase Changes. J. Am. Chem. Soc. 2005, 127, 6641-6651.
  • 23
    • 0033151448 scopus 로고    scopus 로고
    • Factors Affecting the Degradation Rate of Poly(lactide-co-glycolide) Microspheres In Vivo and In Vitro
    • Tracy, M. A.; Ward, K. L.; Firouzabadian, L.; Wang, Y.; Dong, N.; Qian, R.; Zhang, Y. Factors Affecting the Degradation Rate of Poly(lactide-co-glycolide) Microspheres In Vivo and In Vitro. Biomaterials. 1999, 20, 1057-1062.
    • (1999) Biomaterials , vol.20 , pp. 1057-1062
    • Tracy, M.A.1    Ward, K.L.2    Firouzabadian, L.3    Wang, Y.4    Dong, N.5    Qian, R.6    Zhang, Y.7
  • 24
    • 1542615793 scopus 로고    scopus 로고
    • Protein Powders for Encapsulation: A Comparison of Spray-freeze Drying and Spray Drying of Darbepoetin Alfa
    • Nguyen, X. C.; Herberger, J. D.; Burke, P. A. Protein Powders for Encapsulation: A Comparison of Spray-freeze Drying and Spray Drying of Darbepoetin Alfa. Pharm. Res. 2004, 21 (3), 507-514.
    • (2004) Pharm. Res , vol.21 , Issue.3 , pp. 507-514
    • Nguyen, X.C.1    Herberger, J.D.2    Burke, P.A.3
  • 25
    • 1542511345 scopus 로고    scopus 로고
    • Poly(lactide-co-glycolide) Microsphere Formulations of Darbepoetin Alfa: Spray Drying Is an Alternative to Encapsulation by Spray-freeze Drying
    • Burke, P. A.; Klumb, L. A.; Herberger, J. D.; Nguyen, X. C. C.; Harrell, R. A.; Zordich, M. Poly(lactide-co-glycolide) Microsphere Formulations of Darbepoetin Alfa: Spray Drying Is an Alternative to Encapsulation by Spray-freeze Drying. Pharm. Res. 2004, 21, 500-506.
    • (2004) Pharm. Res , vol.21 , pp. 500-506
    • Burke, P.A.1    Klumb, L.A.2    Herberger, J.D.3    Nguyen, X.C.C.4    Harrell, R.A.5    Zordich, M.6
  • 26
    • 0001709105 scopus 로고
    • Humidity Control in the Laboratory Using Salt Solutions - A Review
    • Young, J. F. Humidity Control in the Laboratory Using Salt Solutions - A Review. J. Appl. Chem. 1967, 17, 241-245.
    • (1967) J. Appl. Chem , vol.17 , pp. 241-245
    • Young, J.F.1
  • 28
    • 0032543119 scopus 로고    scopus 로고
    • Water Sorption Behavior of Lyophilized Protein-sugar Systems and Implications for Solid-state Interactions
    • Costantino, H. R.; Curley, J. G.; Wu, S.; Hsu, C. C. Water Sorption Behavior of Lyophilized Protein-sugar Systems and Implications for Solid-state Interactions. Int. J. Pharm. 1998, 166, 211-221.
    • (1998) Int. J. Pharm , vol.166 , pp. 211-221
    • Costantino, H.R.1    Curley, J.G.2    Wu, S.3    Hsu, C.C.4
  • 31
    • 0016207120 scopus 로고
    • Carbon-13 Nuclear Magnetic Resonance Studies of Structure and Function in Thyrotropin-releasing Factor. Determination of the Tautomeric Form of Histidine and Relationship to Biology Activity
    • Deslauriers, R.; McGregor, W. H.; Sarantakis, D.; Smith, I. C. Carbon-13 Nuclear Magnetic Resonance Studies of Structure and Function in Thyrotropin-releasing Factor. Determination of the Tautomeric Form of Histidine and Relationship to Biology Activity. Biochemistry 1974, 13, 3443-3448.
    • (1974) Biochemistry , vol.13 , pp. 3443-3448
    • Deslauriers, R.1    McGregor, W.H.2    Sarantakis, D.3    Smith, I.C.4
  • 32
    • 0021711021 scopus 로고
    • Macromolecular Diffusion Through Polymer Membranes
    • Sato, S.; Kim, S. W. Macromolecular Diffusion Through Polymer Membranes. Int. J. Pharm. 1984, 20, 229-255.
    • (1984) Int. J. Pharm , vol.20 , pp. 229-255
    • Sato, S.1    Kim, S.W.2
  • 33
    • 0037151323 scopus 로고    scopus 로고
    • Characterization of the Initial Burst Release of a Model Peptide from Poly(D,L-lactide-co-glycolide) Microspheres
    • Wang, J.; Wang, B. A.; Schwendeman, S. P. Characterization of the Initial Burst Release of a Model Peptide from Poly(D,L-lactide-co-glycolide) Microspheres. J. Controlled Release 2002, 82, 289-307.
    • (2002) J. Controlled Release , vol.82 , pp. 289-307
    • Wang, J.1    Wang, B.A.2    Schwendeman, S.P.3
  • 34
    • 0037465487 scopus 로고    scopus 로고
    • Determination of Diffusion Coefficient of a Small Hydrophobic Probe in Poly(lactide-co-glycolide) Microparticles by Laser Scanning Confocal Microscopy
    • Kang, J. C.; Schwendeman, S. P. Determination of Diffusion Coefficient of a Small Hydrophobic Probe in Poly(lactide-co-glycolide) Microparticles by Laser Scanning Confocal Microscopy. Macromolecules 2003, 36, 1324-1330.
    • (2003) Macromolecules , vol.36 , pp. 1324-1330
    • Kang, J.C.1    Schwendeman, S.P.2
  • 36
    • 0031474199 scopus 로고    scopus 로고
    • Batycky, R. P.; Hanes, J.; Langer, R.; Edwards, D. A. A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres. J. Pharm. Sci. 1997, 86, 1464-1477.
    • Batycky, R. P.; Hanes, J.; Langer, R.; Edwards, D. A. A Theoretical Model of Erosion and Macromolecular Drug Release from Biodegrading Microspheres. J. Pharm. Sci. 1997, 86, 1464-1477.
  • 37
    • 0033047392 scopus 로고    scopus 로고
    • Use of Infrared Spectroscopy to Assess Secondary Structure of Human Growth Hormone Within Biodegradable Microspheres
    • Yang, T. H.; Dong, A. C.; Meyer, J.; Johnson, O. L.; Cleland, J. L.; Carpenter, J. F. Use of Infrared Spectroscopy to Assess Secondary Structure of Human Growth Hormone Within Biodegradable Microspheres. J. Pharm. Sci. 1999, 88, 161-165.
    • (1999) J. Pharm. Sci , vol.88 , pp. 161-165
    • Yang, T.H.1    Dong, A.C.2    Meyer, J.3    Johnson, O.L.4    Cleland, J.L.5    Carpenter, J.F.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.