Spinal activation of the cAMP-PKA pathway induces respiratory motor recovery following high cervical spinal cord injury

Brain Research

Volumn 1232, Issue , 2008, Pages 206-213

  Kajana, S ^a   Goshgarian, H G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

cAMP; Cervical spinal cord injury; Crossed phrenic pathway; PKA; Respiration

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PANCURONIUM;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREATHING MECHANICS; CERVICAL SPINAL CORD INJURY; CONTROLLED STUDY; ENZYME ACTIVATION; MALE; NONHUMAN; PARALYSIS; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RESPIRATORY FUNCTION; SIGNAL TRANSDUCTION; SPINAL CORD HEMISECTION; VAGOTOMY;

ANIMALS; APNEA; CARBON DIOXIDE; CERVICAL VERTEBRAE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DATA INTERPRETATION, STATISTICAL; ELECTROPHYSIOLOGY; ENZYME INHIBITORS; FUNCTIONAL LATERALITY; MALE; PHRENIC NERVE; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY PHYSIOLOGICAL PROCESSES; SIGNAL TRANSDUCTION; SPINAL CORD; SPINAL CORD INJURIES; THIONUCLEOTIDES;

RATTUS;

EID: 51049089530     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.07.012     Document Type: Article

References (44)

1. Alilain W.J., and Goshgarian H.G. MK-801 upregulates NR2A protein levels and induces functional recovery of the ipsilateral hemidiaphragm following acute C2 hemisection in adult rats. J. Spinal Cord Med. 30 (2007) 346-354
2. Arata A., Onimaru H., and Homma I. Effects of cAMP on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rat. Brain Res. 605 (1993) 193-199
3. Aserinsky E. Effects of usage of a dormant respiratory nerve pathway upon its subsequent activity. Exp. Neurol. 3 (1961) 467-475
4. Banke T.G., Bowie D., Lee H., Huganir R.L., Schousboe A., and Traynelis S.F. Control of GluR1 AMPA receptor function by cAMP-dependent protein kinase. J. Neurosci. 20 (2000) 89-102
5. Banko J.L., Hou L., and Klann E. NMDA receptor activation results in PKA- and ERK-dependent Mnk1 activation and increased eIF4E phosphorylation in hippocampal area CA1. J. Neurochem. 91 (2004) 462-470
6. Beebe S.J. The cAMP-dependent protein kinases and cAMP signal transduction. Semin. Cancer Biol. 5 (1994) 285-294
7. Blackstone C., Murphy T.H., Moss S.J., Baraban J.M., and Huganir R.L. Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors. J. Neurosci. 14 (1994) 7585-7593
8. Bocchiaro C.M., Saywell S.A., and Feldman J.L. Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons. J. Neurosci. 23 (2003) 1099-1103
9. Deason R., and L.J. On the pathways for the bulbar respiratory impulses in the spinal cord. Am. J. Physiol. 28 (1911) 57-63
10. Eliot L.S., Dudai Y., Kandel E.R., and Abrams T.W. Ca2+/calmodulin sensitivity may be common to all forms of neural adenylate cyclase. Proc. Natl. Acad. Sci. U. S. A. 86 (1989) 9564-9568
11. Fujii M., Umezawa K., and Arata A. Dopaminergic modulation on respiratory rhythm in rat brainstem-spinal cord preparation. Neurosci. Res. 50 (2004) 355-359
12. Goshgarian H.G. The role of cervical afferent nerve fiber inhibition of the crossed phrenic phenomenon. Exp. Neurol. 72 (1981) 211-225
13. Greengard P., Jen J., Nairn A.C., and Stevens C.F. Enhancement of the glutamate response by cAMP-dependent protein kinase in hippocampal neurons. Science 253 (1991) 1135-1138
14. Guth L. Functional plasticity in the respiratory pathway of the mammalian spinal cord. Exp. Neurol. 51 (1976) 414-420
15. Huang Y.Y., and Kandel E.R. Postsynaptic induction and PKA-dependent expression of LTP in the lateral amygdala. Neuron 21 (1998) 169-178
16. Hussein A., Al-Wadei N., Takahashi T., and Schuller H.M. Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia. Int. J. Oncol. 27 (2005) 155-160
17. Inan M., Lu H.C., Albright M.J., She W.C., and Crair M.C. Barrel map development relies on protein kinase A regulatory subunit II beta-mediated cAMP signaling. J. Neurosci. 26 (2006) 4338-4349
18. Kajana S., and Goshgarian H.G. Administration of phosphodiesterase inhibitors and an adenosine A1 receptor antagonist induces phrenic nerve recovery in high cervical spinal cord injured rats. Experimental Neurology 210 (2008) 671-680
19. Lalley P.M., Pierrefiche O., Bischoff A.M., and Richter D.W. cAMP-dependent protein kinase modulates expiratory neurons in vivo. J. Neurophysiol. 77 (1997) 1119-1131
20. Lee H.K., Barbarosie M., Kameyama K., Bear M.F., and Huganir R.L. Regulation of distinct AMPA receptor phosphorylation sites during bidirectional synaptic plasticity. Nature 405 (2000) 955-959
21. Lewis L.J., and Brookhart J.M. Significance of the crossed phrenic phenomenon. Am. J. Physiol. 166 (1951) 241-254
22. Liu X.S., Xu Y.J., Zhang Z.X., Li C.Q., Yang D.L., Zhang N., and Ni W. Isoprenaline and aminophylline relax bronchial smooth muscle by cAMP-induced stimulation of large-conductance Ca2+-activated K+ channels. Acta. Pharmacol. Sin. 24 (2003) 408-414
23. McCrimmon D.R., Smith J.C., and Feldman J.L. Involvement of excitatory amino acids in neurotransmission of inspiratory drive to spinal respiratory motoneurons. J. Neurosci. 9 (1989) 1910-1921
24. Moreno D.E., Yu X.J., and Goshgarian H.G. Identification of the axon pathways which mediate functional recovery of a paralyzed hemidiaphragm following spinal cord hemisection in the adult rat. Exp. Neurol. 116 (1992) 219-228
25. Munno D.W., Prince D.J., and Syed N.I. Synapse number and synaptic efficacy are regulated by presynaptic cAMP and protein kinase A. J. Neurosci. 23 (2003) 4146-4155
26. Murphy D.D., and Segal M. Morphological plasticity of dendritic spines in central neurons is mediated by activation of cAMP response element binding protein. Proc. Natl. Acad. Sci. U. S. A. 94 (1997) 1482-1487
27. Nantwi K.D., and Goshgarian H.G. Effects of chronic systemic theophylline injections on recovery of hemidiaphragmatic function after cervical spinal cord injury in adult rats. Brain Res. 789 (1998) 126-129
28. Nantwi K.D., and Goshgarian H.G. Actions of specific adenosine receptor A1 and A2 agonists and antagonists in recovery of phrenic motor output following upper cervical spinal cord injury in adult rats. Clin. Exp. Pharmacol. Physiol. 29 (2002) 915-923
29. Nantwi K.D., and Goshgarian H.G. Adenosinergic mechanisms underlying recovery of diaphragm motor function following upper cervical spinal cord injury: potential therapeutic implications. Neurol. Res. 27 (2005) 195-205
30. Nantwi K.D., El-Bohy A., and Goshgarian H.G. Actions of systemic theophylline on hemidiaphragmatic recovery in rats following cervical spinal cord hemisection. Exp. Neurol. 140 (1996) 53-59
31. Nguyen P.V., and Woo N.H. Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Prog. Neurobiol. 71 (2003) 401-437
32. Rosenbaum H., and Renshaw B. Descending respiratory pathways in the cervical spinal cord. Am. J. Physiol. 157 (1949) 468-476
33. Rosenblueth A., and O.T. The crossed respiratory impulses to the phrenic. Am. J. Physiol. 117 (1936) 495-513
34. Saywell S.A., and Feldman J.L. Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA. J. Physiol. 554 (2004) 879-889
35. Schwartz J.H. The many dimensions of cAMP signaling. Proc. Natl. Acad. Sci. U. S. A. 98 (2001) 13482-13484
36. Shao X.M., Ge Q., and Feldman J.L. Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J. Physiol. 547 (2003) 543-553
37. Skalhegg B.S., and Tasken K. Specificity in the cAMP/PKA signalling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Fron. Biosci. 5 (2000) D678-D693
38. Skeberdis V.A., Chevaleyre V., Lau C.G., Goldberg J.H., Pettit D.L., Suadicani S.O., Lin Y., Bennett M.V., Yuste R., Castillo P.E., and Zukin R.S. Protein kinase A regulates calcium permeability of NMDA receptors. Nat. Neurosci. 9 (2006) 501-510
39. Tominaga-Yoshino K., Kondo S., Tamotsu S., and Ogura A. Repetitive activation of protein kinase A induces slow and persistent potentiation associated with synaptogenesis in cultured hippocampus. Neurosci. Res. 44 (2002) 357-367
40. Tronson N.C., Wiseman S.L., Olausson P., and Taylor J.R. Bidirectional behavioral plasticity of memory reconsolidation depends on amygdalar protein kinase A. Nat. Neurosci. 9 (2006) 167-169
41. Waltereit R., and Weller M. Signaling from cAMP/PKA to MAPK and synaptic plasticity. Mol. Neurobiol. 27 (2003) 99-106
42. Winslow C., and Rozovsky J. Effect of spinal cord injury on the respiratory system. Am. J. Phys. Med. Rehabil. 82 (2003) 803-814
43. Yamamoto M., Urakubo T., Tominaga-Yoshino K., and Ogura A. Long-lasting synapse formation in cultured rat hippocampal neurons after repeated PKA activation. Brain Res. 1042 (2005) 6-16
44. Zimmer M.B., and Goshgarian H.G. Spinal activation of serotonin 1A receptors enhances latent respiratory activity after spinal cord injury. J. Spinal Cord Med. 29 (2006) 147-155