Actions of systemic theophylline on hemidiaphragmatic recovery in rats following cervical spinal cord hemisection

Experimental Neurology

Volumn 140, Issue 1, 1996, Pages 53-59

  Nantwi, K D ^a   El Bohy, A ^a   Goshgarian, H G ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THEOPHYLLINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CERVICAL SPINAL CORD; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; HEMIDIAPHRAGM; MOTONEURON; NERVE CELL PLASTICITY; NERVE CONDUCTION; NONHUMAN; PHRENIC NERVE; PRIORITY JOURNAL; RAT; RESPIRATION CONTROL; SPINAL CORD INJURY; SPINAL CORD TRANSSECTION;

EID: 0030198950     PISSN: 00144886     EISSN: None     Source Type: Journal    
DOI: 10.1006/exnr.1996.0114     Document Type: Article

References (32)

1. 1. AUBIER, M., MURCIANO, D., VIRES, N., LECOCGUIC, Y., PALACIOS, AND PARIENTE, R. 1983. Increased ventilation caused by improved diaphragmatic efficiency during aminophylline infusion. Am. Rev. Res. Dis. 127: 148-154.
2. 2. DECRAMER, M., DESCHEPPER, K., JIANG, T-X., AND DEROM, E. 1991. Effects of aminophylline on respiratory muscle interaction. Am. Rev. Respir. Dis. 144: 797-802.
3. 3. ELDRIDGE, F. L., MILLHORN, D. E., WALDROP, T. G., AND KILEY, J. P. 1983. Mechanisms of respiratory effects of methylxanthines. Resp. Physiol. 53: 239-261.
4. 4. FILUK, R. B., EASTON, P. A., AND ANTHONISEN, N. R. 1985. Responses to large doses of salbutamol and theophylline in patients with chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 132: 871-874.
5. 5. FREDHOLM, B. B., AND PERSSON, C. G. A. 1982. Xanthine derivatives as adenosine receptor antagonists. Eur. J. Pharmacol. 81: 673-676.
6. 6. GAYAN-RAMIREZ, G., AND DECRAMER, M. 1994. Inotropic effects of theophylline on foreshortened canine diaphragm. Am. J. Respir. Crit. Care Med. 149: 920-924.
7. 7. GOSHGARIAN, H. G. 1979. Developmental plasticity in the respiratory pathway of the adult rat. Exp. Neurol. 66: 547-555.
8. 8. GOSHGARIAN, H. G., AND GUTH, L. 1977. Demonstration of functionally ineffective synapses in the guinea pig spinal cord. Exp. Neurol. 57: 613-621.
9. 9. GOSHGARIAN, H. G., MORAN, M. F., AND PRCEVSKI, P. 1986. Effect of cervical spinal cord hemisection and diaphragm paralysis on arterial blood gases, pH, and respiratory rate in the adult rat. Exp. Neurol. 93: 440-445.
10. 10. GOSHGARIAN, H. G., Yu, X-J., AND RAFOLS, J. A. 1989. Neuronal and glial changes in the rat phrenic nucleus occurring within hours after spinal cord injury. J. Comp. Neurol. 284: 519-533.
11. 11. HOWELL, S., AND ROUSSOS, C. 1984. Isoproterenol and aminophylline improve contractility in fatigued canine diaphragm. Am. Rev. Respir. Dis. 129: 118-124.
12. 12. HIGBEE, M. D., KUMAR, M., AND GALANT, S. P. 1982. Stimulation of endogenous catecholamine release by theophylline: A proposed additional mechanism of action for theophylline effects. J. Allergy Clin. Immunol. 70: 377-382.
13. 13. JACOBSON, K. A., VAN GALEN, P. J. M., AND WILLIAMS, M. 1992. Adenosine receptors: Pharmacology, structure-activity relationships, and therapeutic potential. J. Med. Chem. 35: 407-422.
14. 14. LAKSHMINARAYAN, S., SAHN, S. A., AND WEIL, J. V. 1978. Effect of aminophylline on ventilatory responses in normal man. Am. Rev. Respir. Dis. 117: 33-38.
15. 15. LEWIS, L. J., AND BROOKHART, J. M. 1951. Significance of the crossed phrenic phenomenon. Am. J. Physiol. 166: 241-254.
16. 16. Liou, W. W., AND GOSHGARIAN, H. G. 1994. Quantitative assessment of the effect of chronic phrenicotomy on the induction of the crossed phrenic phenomenon. Exp. Neurol. 127: 145-153.
17. 17. LUNDBERG, D. B., BREESE, G. R., AND MUELLER, R. A. 1981. Aminophylline may stimulate respiration in rats by activation of dopaminergic receptors. J. Pharmacol. Exp. Ther. 217: 215-221.
18. 18. MILICA, P., TODOROVIC, Z., AND VARAGIC. 1992. Some new evidence on antifatigue action of aminophylline on the isolated hemidiaphragm of the rat. Gen. Pharmacol. 24: 225-232.
19. 19. MORENO, D. E., Yu, X-J., AND GOSHGARIAN, H. G. 1992. Identification of the axon pathways which mediate functional recovery of a paralyzed hemidiaphragm following spinal cord hemisection in the adult rat. Exp. Neurol. 116: 219-228.
20. 20. MUELLER, R. A., LUNDBERG, D. B., AND BREESE, G. R. 1981. Alteration of aminophylline-induced respiratory stimulation by perturbation of biogenic amine systems. J. Pharmacol. Exp. Ther. 218: 593-599.
21. 21. MULLOY, E., AND MCNICHOLAS, W. T. 1993. Theophylline improves gas exchange during rest, exercise, and sleep in severe chronic obstructive pulmonary disease. Am. Rev. Respir. Dis. 148: 1030-1036.
22. 22. MURCIANO, D., AUBIER, M., VIIRES, N., MAL, H., AND PARIENTE, R. 1987. Effects of theophylline and enprofylline on diaphragmatic contractility. J. Appl. Physiol. 63(1): 51-57.
23. 23. NACHAZEL, J., AND PALECEK. 1990. Aminophylline enhances ventilation in phrenicotomized rats. Eur. Respir. J. 3: 311-317.
24. 24. NEWMAN, D., TAMIR, J., SPEEDY, L., NEWMAN, J. P., AND BEN-DOV, I. 1994. Physiological and neuropsychological effects of theophylline in chronic obstructive pulmonary disease. Isr. J. Med. Sci. 30: 811-816.
25. 25. O'HARA, T. E., JR., AND GOSHGARIAN, H. G. 1991. Quantitative assessment of phrenic nerve functional recovery mediated by the crossed phrenic reflex at various time intervals after spinal cord injury. Exp. Neurol. 111: 244-250.
26. 26. OLSEN, G. D., AND SCHLITT, S. C. 1981. Theophylline effect upon respiration and ventilation in the dog: Interaction with methadone. J. Pharmacol. Exp. Ther. 217: 278-284.
27. 27. PORTER, W. T. 1895. The path of the respiratory impulse from the bulb to the phrenic nuclei. J. Physiol. 17: 455-485.
28. 28. RIEGELMAN, S., AND JENNE, J. W. 1980. Controlled release theophylline. Chest 78: 250-257.
29. 29. RICHMOND, G. H. 1949. Action of caffeine and aminophylline as respiratory stimulants in man. J. Appl. Physiol. 2: 16-23.
30. 30. RITCHIE, J. M. 1990. Central nervous system stimulants: the xanthines. In The Pharmacological Basis of Therapeutics (L. S. Goodman and A. Gilman, Eds.). Pergamon Press, New York.
31. 31. SIGRIST, S., THOMAS, D., HOWELL, S., AND ROUSSOS, C. 1982. The effect of aminophylline on inspiratory muscle contractility. Am. Rev. Res. Dis. 126: 46-50.
32. 32. WOODCOCK, A. A., JOHNSON, M. A., AND GEDDES, D. M. 1983. Theophylline prescribing, serum concentrations, and toxicity. Lancet. 2: 610-613.