Theophylline stimulates cAMP-mediated signaling associated with growth regulation in human cells from pulmonary adenocarcinoma and small airway epithelia

International Journal of Oncology

Volumn 27, Issue 1, 2005, Pages 155-160

  Hussein, A ^a   Al Wadei, N ^a   Takahashi, Takashi ^b   Schuller, Hildegard M ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Airway epithelia; Pulmonary adenocarcinoma

Indexed keywords

CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FORSKOLIN; PHOSPHODIESTERASE INHIBITOR; TETRAZOLIUM; THEOPHYLLINE; THIAZOLE DERIVATIVE; THIAZOLYL BLUE;

ADENOCARCINOMA; AGAR GEL ELECTROPHORESIS; ANIMAL; ARTICLE; CELL PROLIFERATION; CYTOLOGY; DOSE RESPONSE; EPITHELIUM CELL; HAMSTER; HUMAN; IMMUNOASSAY; LUNG TUMOR; METABOLISM; PATHOLOGY; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; TIME; TRACHEA; TUMOR CELL LINE; WESTERN BLOTTING;

ADENOCARCINOMA; ANIMALS; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; CRICETINAE; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHORESIS, AGAR GEL; EPITHELIAL CELLS; FORSKOLIN; HUMANS; IMMUNOASSAY; LUNG NEOPLASMS; MAP KINASE SIGNALING SYSTEM; MUSCLE, SMOOTH; PHOSPHODIESTERASE INHIBITORS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; TETRAZOLIUM SALTS; THEOPHYLLINE; THIAZOLES; TIME FACTORS; TRACHEA;

EID: 24644487728     PISSN: 10196439     EISSN: 17912423     Source Type: Journal    
DOI: 10.3892/ijo.27.1.155     Document Type: Article

References (20)

1. Choi SY, Chung MJ and Sung NJ: Volatile N-nitrosamine inhibition after intake Korean green tea and Maesil (Prunus mume SIEB, et ZACC.) extracts with an amine-rich diet in subjects ingesting nitrate. Food Chem Toxicol 40: 949-957, 2002.
2. Chung FL: The prevention of lung cancer induced by a tobacco-specific carcinogen in rodents by green and black Tea. Proc Soc Exp Biol Med 220: 244-248, 1999.
3. Dhawan A, Anderson D, De Pascual-Teresa S, Santos-Buelga C, Clifford MN and Ioannides C: Evaluation of the antigenotoxic potential of monomeric and dimeric flavanols, and black tea polyphenols against heterocyclic amine-induced DNA damage in human lymphocytes using the Comet assay. Mutat Res 515: 39-56,2002.
4. Lee KW, Lee HJ and Lee CY: Antioxidant activity of black tea vs. green tea. I Nutr 132: 785-786, 2002.
5. Bertram B and Bartsch H: Cancer prevention with green tea: reality and wishful thinking. Wien Med Wochenschr 152: 153-158,2002.
6. Bushman JL: Green tea and cancer in humans: a review of the literature. Nutr Cancer 31: 151-159, 1998.
7. Tewes FJ, Koo LC, Meisgen TJ and Rylander R: Lung cancer risk and mutagenicity of tea. Environ Res 52: 23-33, 1990.
8. Levi F, Franceschi S, La Vecchia C, Randimbison L and Te VC: Lung carcinoma trends by histologic type in Vaud and Neuchatel, Switzerland, 1974-1994. Cancer 79: 906-914, 1997.
9. Wynder EL and Muscat JE: The changing epidemiology of smoking and lung cancer histology. Environ Health Perspect 103 (Suppl 8): 143-148, 1995.
10. Belinsky SA, Devereux TR, Foley JF, Maronpot RR and Anderson MW: Role of the alveolar type II cell in the development and progression of pulmonary tumors induced by 4-(methylnitrosamino)-l-(3-pyridyl)-l-butanone in the A/J mouse. Cancer Res 52: 3164-3173, 1992.
11. Rehm S, Devor DE, Henneman JR and Ward JM: Origin of spontaneous and transplacental^ induced mouse lung tumors from alveolar type 11 cells. Exp Lung Res 17: 181-195, 1991.
12. Albertine KH, Steiner RM, Radack DM, Golding DM, Peterson D, Cohn HE and Farber JL: Analysis of cell type and radiographic presentation as predictors of the clinical course of patients with bronchioalveolar cell carcinoma. Chest 113: 997-1006, 1998.
13. Schuller HM, Tithof PK, Williams M and Plummer H III: The tobacco-specific carcinogen 4-(methylnitrosamino)-l-(3-pyridyl)-1-butanone is a beta-adrenergic agonist and stimulates DNA synthesis in lung adenocarcinoma via beta-adrenergic receptor-mediated release of arachidonic acid. Cancer Res 59: 4510-4515, 1999.
14. Schuller HM, Porter B and Riechert A: Beta-adrenergic modulation of NNK-induced lung carcinogenesis in hamsters. J Cancer Res Clin Oncol 126: 624-630, 2000.
15. Adissu HA and Schuller HM: Antagonistic growth regulation of cell lines derived from human lung adenocarcinomas of Clara cell and aveolar type II cell lineage: Implications for chemoprevention. Int J Oncol 24: 1467-1472, 2004.
16. Schuller HM, Porter B, Riechert A, Walker K and Schmoyer R: Neuroendocrine lung carcinogenesis in hamsters is inhibited by green tea or theophylline while the development of adenocarcinomas is promoted: implications for chemoprevention in smokers. Lung Cancer 45: 11-18,2004.
17. Rail TW: Drugs used in the treatment of asthma. In: The Pharmacological Basis of Therapeutics. Goddman Gilman A, Rail WT, Nies AS and Taylor P (eds). New York, Pergamon Press, pp618-637, 1990.
18. Aksoy MO, Mardini IA, Yang Y, Bin W, Zhou S and Kelsen SG: Glucocorticoid effects on the beta-adrenergic receptor-adenylyl cyclase system of human airway epithelium. J Allergy Clin Immunol 109:491-497, 2002.
19. Masuda A, Kondo M, Saito T, Yatabe Y, Kobayashi T, Okamoto M, Suyama M and Takahashi T: Establishment of human peripheral lung epithelial cell lines (HPL1) retaining differentiated characteristics and responsiveness to epidermal growth factor, hepatocyte growth factor, and transforming growth factor betal. Cancer Res 57: 4898-4904, 1997.
20. Shafer SH, Phelps SH and Williams CL: Reduced DNA synthesis and cell viability in small cell lung carcinoma by treatment with cyclic AMP phosphodiesterase inhibitors. Biochem Pharmacol 56: 1229-1236, 1998.