Triggered release of siRNA from poly(ethylene glycol)-protected, pH-dependent liposomes

Journal of Controlled Release

Volumn 130, Issue 3, 2008, Pages 266-274

  Auguste, Debra T ^a   Furman, Kay ^a   Wong, Andrew ^b   Fuller, Jason ^a   Armes, Steven P ^c   Deming, Timothy J ^d   Langer, Robert ^a  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b HARVARD UNIVERSITY   (United States)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Genedelivery; Liposome; PEG; pH dependent; RNAi; siRNA

Indexed keywords

ABS RESINS; ACIDS; CELL MEMBRANES; CHLORINE COMPOUNDS; DESORPTION; ETHYLENE; ETHYLENE GLYCOL; GENE EXPRESSION; LIPOSOMES; NUCLEIC ACIDS; PHOSPHOLIPIDS; POLYETHYLENE GLYCOLS; POLYMERS; PROPANE; RNA;

GENEDELIVERY; LIPOSOME; PEG; PH-DEPENDENT; RNAI; SIRNA;

ENDOTHELIAL CELLS;

1,2 DIOLEOYL 3 DIMETHYLAMMONIUM PROPANE; AMMONIUM DERIVATIVE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; GREEN FLUORESCENT PROTEIN; LIPOSOME; MACROGOL; METHACRYLIC ACID DERIVATIVE; POLY [2 (DIMETHYLAMINO)ETHY METHACRYLATE]; POLYLYSINE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ARTICLE; CONTROLLED STUDY; DESORPTION; DRUG DELIVERY SYSTEM; DRUG RELEASE; ENDOSOME; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ADSORPTION; CELLS, CULTURED; ENDOTHELIAL CELLS; GENE EXPRESSION; GENE TRANSFER TECHNIQUES; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; LIPIDS; LIPOSOMES; METHACRYLATES; PARTICLE SIZE; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLETHANOLAMINES; PHOSPHATIDYLSERINES; POLYETHYLENE GLYCOLS; RHODAMINES; RNA, SMALL INTERFERING;

EID: 50949095169     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.06.004     Document Type: Article

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