Lidocaine-induced brugada syndrome phenotype linked to a novel double mutation in the cardiac sodium channel

Circulation Research

Volumn 103, Issue 4, 2008, Pages 396-404

  Barajas Martínez, Hector M ^a,b,c,h   Hu, Dan ^a,d   Cordeiro, Jonathan M ^a   Wu, Yuesheng ^a   Kovacs, Richard J ^e   Meltser, Henry ^e   Kui, Hong ^f   Elena, Burashnikov ^a   Brugada, Ramon ^g   Antzelevitch, Charles ^a   Dumaine, Robert ^h  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

^b South University Center   (Mexico)

^c UNIVERSITY OF GUADALAJARA   (Mexico)

^d RENMIN HOSPITAL OF WUHAN UNIVERSITY   (China)

^e INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^f NANCHANG UNIVERSITY   (China)

^g MONTREAL HEART INSTITUTE   (Canada)

^h UNIVERSITY OF SHERBROOKE   (Canada)

Author keywords

Arrhythmia (mechanisms); Brugada syndrome; Ion channels; Na channels; Sudden death

Indexed keywords

ANTIARRHYTHMIC AGENT; ION CHANNEL; LIDOCAINE; SODIUM CHANNEL; LOCAL ANESTHETIC AGENT; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN;

ADULT; ARTICLE; BRUGADA SYNDROME; CASE REPORT; CHANNEL GATING; ELECTROCARDIOGRAM; GENE MUTATION; GENETIC VARIABILITY; HUMAN; MALE; MAMMAL; MISSENSE MUTATION; MUTAGENESIS; MUTANT; PATCH CLAMP; PHENOTYPE; PRIORITY JOURNAL; STEADY STATE; WILD TYPE; ELECTROCARDIOGRAPHY; GENETICS; MIDDLE AGED; PATHOPHYSIOLOGY;

ANESTHETICS, LOCAL; BRUGADA SYNDROME; ELECTROCARDIOGRAPHY; HUMANS; LIDOCAINE; MALE; MIDDLE AGED; MUSCLE PROTEINS; MUTATION, MISSENSE; PHENOTYPE; SODIUM CHANNELS;

EID: 50949092654     PISSN: 00097330     EISSN: 15244571     Source Type: Journal    
DOI: 10.1161/CIRCRESAHA.108.172619     Document Type: Article

References (44)

1. Brugada P, Brugada J. Right bundle branch block, persistent ST segment elevation and sudden cardiac death: a distinct clinical and electrocardiographic syndrome: a multicenter report. J Am Coll Cardiol. 1992;20: 1391-1396.
2. Antzelevitch C, Brugada P, Brugada J, Brugada R. The Brugada Syndrome: From Bench to Bedside. Oxford: Blackwell Futura; 2005.
3. Brugada R, Brugada J, Antzelevitch C, Kirsch GE, Potenza D, Towbin JA, Brugada P. Sodium channel blockers identify risk for sudden death in patients with ST-segment elevation and right bundle branch block but structurally normal hearts. Circulation. 2000;101:510-515.
4. Shimizu W, Antzelevitch C, Suyama K, Kurita T, Taguchi A, Aihara N, Takaki H, Sunagawa K, Kamakura S. Effect of sodium channel blockers on ST segment, QRS duration, and corrected QT interval in patients with Brugada syndrome. J Cardiovasc Electrophysiol. 2000; 11:1320-1329.
5. Brugada R, Hong K, Dumaine R, Cordeiro J, Gaita F, Borggrefe M, Menendez TM, Brugada J, Pollevick GD, Wolpert C, Burashnikov E, Matsuo K, Wu YS, Guerchicoff A, Bianchi F, Giustetto C, Schimpf R, Brugada P, Antzelevitch C. Sudden death associated with short-QT syndrome linked to mutations in HERG. Circulation. 2004;109: 30-35.
6. Dumaine R, Towbin JA, Brugada P, Vatta M, Nesterenko VV, Nest-erenko DV, Brugada J, Brugada R, Antzelevitch C. Ionic mechanisms responsible for the electrocardiographic phenotype of the Brugada syndrome are temperature dependent. Circ Res. 1999;85:803-809.
7. Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol. 1977;69:497-515.
8. Hondeghem LM, Katzung BG. Time-and voltage-dependent interactions of antiarrhythmic drugs with cardiac sodium channels. Biochim Biophys Acta. 1977;472:373-398.
9. Ackerman MJ, Splawski I, Makielski JC, Tester DJ, Will ML, Timothy KW, Keating MT, Jones G, Chadha M, Burrow CR, Stephens JC, Xu C, Judson R, Curran ME. Spectrum and prevalence of cardiac sodium channel variants among black, white, Asian, and Hispanic individuals: implications for arrhythmogenic susceptibility and Brugada/long QT syndrome genetic testing. Heart Rhythm. 2004;1:600-607.
10. Sunami A, Dudley SC Jr, Fozzard HA. Sodium channel selectivity filter regulates antiarrhythmic drug binding. Proc Natl Acad Sci USA. 1997; 94:14126-14131.
11. Sunami A, Glaaser IW, Fozzard HA. A critical residue for isoform difference in tetrodotoxin affinity is a molecular determinant of the external access path for local anesthetics in the cardiac sodium channel. Proc Natl Acad Sci USA. 2000;97:2326-2331.
12. Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. Common molecular determinants of local anesthetic, antiarrhythmic, and anticonvulsant block of voltage-gated Na+ channels. Proc Natl Acad Sci USA. 1996;93: 9270-9275.
13. Chanda B, Bezanilla F. Tracking voltage-dependent conformational changes in skeletal muscle sodium channel during activation. J Gen Physiol. 2002;120:629-645.
14. Chanda B, Asamoah OK, Bezanilla F. Coupling interactions between voltage sensors of the sodium channel as revealed by site-specific measurements. J Gen Physiol. 2004;123:217-230.
15. Kuhn FJ, Greeff NG. Movement of voltage sensor S4 in domain 4 is tightly coupled to sodium channel fast inactivation and gating charge immobilization. J Gen Physiol. 1999;114:167-183.
16. Chen LQ, Santarelli V, Horn R, Kallen RG. A unique role for the S4 segment of domain 4 in the inactivation of sodium channels. J Gen Physiol. 1996;108:549-556.
17. Cha A, Ruben PC, George AL Jr, Fujimoto E, Bezanilla F. Voltage sensors in domains III and IV, but not I and II, are immobilized by Na + channel fast inactivation. Neuron. 1999;22:73-87.
18. Popa MO, Alekov AK, Bail S, Lehmann-Horn F, Lerche H. Cooperative effect of S4-S5 loops in domains D3 and D4 on fast inactivation of the Na+ channel. J Physiol. 2004;561:39-51.
19. Sheets MF, Hanck DA. Molecular action of lidocaine on the voltage sensors of sodium channels. J Gen Physiol. 2003;121:163-175.
20. Ragsdale DS, McPhee JC, Scheuer T, Catterall WA. Molecular determinants of state-dependent block of Na+ channels by local anesthetics. Science. 1994;265:1724-1728.
21. Wang GK, Quan C, Wang S. A common local anesthetic receptor for benzocaine and etidocaine in voltage-gated mu1 Na+ channels. Pflugers Arch. 1998;435:293-302.
22. Catterall WA. Molecular mechanisms of gating and drug block of sodium channels. Novartis Found Symp. 2002;241:206-218.
23. Yarov-Yarovoy V, McPhee JC, Idsvoog D, Pate C, Scheuer T, Catterall WA. Role of amino acid residues in transmembrane segments IS6 and IIS6 of the Na+ channel alpha subunit in voltage-dependent gating and drug block. J Biol Chem. 2002;277):35393-35401.
24. del CD, Holmgren M, Liu Y, Yellen G. Blocker protection in the pore of a voltage-gated K+ channel and its structural implications. Nature. 2000; 403:321-325.
25. Perozo E, Cortes DM, Cuello LG. Structural rearrangements underlying K +-channel activation gating. Science. 1999;285:73-78.
26. Hanck DA, Makielski JC, Sheets MF. Lidocaine alters activation gating of cardiac Na channels. Pflugers Arch. 2000;439:814-821.
27. Sheets MF, Hanck DA. Outward stabilization of the S4 segments in domains III and IV enhances lidocaine block of sodium channels. J Physiol. 2007;582:317-334.
28. Brugada P, Brugada J, Brugada R. Arrhythmia induction by antiarrhythmic drugs. Pacing Clin Electrophysiol. 2000;23:291-292.
29. Miyazaki T, Mitamura H, Miyoshi S, Soejima K, Aizawa Y, Ogawa S. Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome. J Am Coll Cardiol. 1996;27: 1061-1070.
30. Babaliaros VC, Hurst JW. Tricyclic antidepressants and the Brugada syndrome: an example of Brugada waves appearing after the administration of desipramine. Clin Cardiol. 2002;25:395-398.
31. Goldgran-Toledano D, Sideris G, Kevorkian JP. Overdose of cyclic antidepressants and the Brugada syndrome. N Engl J Med. 2002;346: 1591-1592.
32. Tada H, Sticherling C, Oral H, Morady F. Brugada syndrome mimicked by tricyclic antidepressant overdose. J Cardiovasc Electrophysiol. 2001; 12:275.
33. Pastor A, Nunez A, Cantale C, Cosio FG. Asymptomatic Brugada syndrome case unmasked during dimenhydrinate infusion. J Cardiovasc Electrophysiol. 2001;12:1192-1194.
34. Ortega-Carnicer J, Bertos-Polo J, Gutierrez-Tirado C. Aborted sudden death, transient Brugada pattern, and wide QRS dysrrhythmias after massive cocaine ingestion. J Electrocardiol. 2001;34:345-349.
35. Nogami A, Nakao M, Kubota S, Sugiyasu A, Doi H, Yokoyama K, Yumoto K, Tamaki T, Kato K, Hosokawa N, Sagai H, Nakamura H, Nitta J, Yamauchi Y, Aonuma K. Enhancement of J-ST-segment elevation by the glucose and insulin test in Brugada syndrome. Pacing Clin Electrophysiol. 2003;26:332-337.
36. Araki T, Konno T, Itoh H, Ino H, Shimizu M. Brugada syndrome with ventricular tachycardia and fibrillation related to hypokalemia. Circ J. 2003;67:93-95.
37. Fujiki A, Usui M, Nagasawa H, Mizumaki K, Hayashi H, Inoue H. ST segment elevation in the right precordial leads induced with class IC antiarrhythmic drugs: insight into the mechanism of Brugada syndrome. J Cardiovasc Electrophysiol. 1999;10:214-218.
38. Gasparini M, Priori SG, Mantica M, Napolitano C, Galimberti P, Ceriotti C, Simonini S. Flecainide test in Brugada syndrome: a reproducible but risky tool. Pacing Clin Electrophysiol. 2003;26:338-341.
39. Takenaka S, Emori T, Koyama S, Morita H, Fukushima K, Ohe T. Asymptomatic form of Brugada syndrome. Pacing Clin Electrophysiol. 1999;22:1261-1263.
40. Shimizu W, Aiba T, Kurita T, Kamakura S. Paradoxic abbreviation of repolarization in epicardium of the right ventricular outflow tract during augmentation of Brugada-type ST segment elevation. J Cardiovasc Elec-trophysiol. 2001;12:1418-1421.
41. Matana A, Goldner V, Stanic K, Mavric Z, Zaputovic L, Matana Z. Unmasking effect of propafenone on the concealed form of the Brugada phenomenon. Pacing Clin Electrophysiol. 2000;23:416-418.
42. Rolf S, Bruns HJ, Wichter T, Kirchhof P, Ribbing M, Wasmer K, Paul M, Breithardt G, Haverkamp W, Eckardt L. The ajmaline challenge in Brugada syndrome: diagnostic impact, safety, and recommended protocol. Eur Heart J. 2003;24:1104-1112.
43. Bolognesi R, Tsialtas D, Vasini P, Conti M, Manca C. Abnormal ventricular repolarization mimicking myocardial infarction after heterocyclic antidepressant overdose. Am J Cardiol. 1997;79:242-245.
44. Rouleau F, Asfar P, Boulet S, Dube L, Dupuis JM, Alquier P, Victor J. Transient ST segment elevation in right precordial leads induced by psychotropic drugs: relationship to the Brugada syndrome. J Cardiovasc Electrophysiol. 2001;12:61-65.