Evolution of enzymes in metabolism: A network perspective

Journal of Molecular Biology

Volumn 320, Issue 4, 2002, Pages 751-770

  Alves, Rui ^a,b   Chaleil, Raphael A G ^b   Sternberg, Michael J E ^a,b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Comparative genomics; Enzyme classification; Metabolic databases; Protein structure; Sequence analysis

Indexed keywords

ARTICLE; CATALYSIS; CHEMICAL REACTION; ENZYME METABOLISM; ENZYME STRUCTURE; GENETIC CONSERVATION; GENOME ANALYSIS; MOLECULAR EVOLUTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN STRUCTURE; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY;

EID: 0036303685     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00546-6     Document Type: Article

References (30)

1. On the evolution of biochemical syntheses
2. Enzyme recruitment in evolution of new function
3. EWIT: Integrated system for high-throughput genome sequence analysis and metabolic reconstruction
4. The evolution and structural anatomy of the small molecule metabolic pathways in Escherichia coli
5. Evolution of function in protein superfamilies, from a structural perspective
6. Functional versatility and molecular diversity of the metabolic map of Escherichia coli
7. On the origin of enzymatic species
8. A structural census of metabolic networks for E. coli
9. 8 barrels: Implications for the evolution of metabolic pathways
10. Divergent evolution of enzymatic function: Mechanistically diverse superfamilies and functionally distinct suprafamilies
11. An ontology for biological function based on molecular interactions
12. KEGG: Kyoto encyclopedia of genes and genomes
13. The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 2000
14. Improving the accuracy of PSI-BLAST protein database searches with composition-based statistics and other refinements
15. SCOP: A structural classification of proteins database for the investigation of sequences and structures
16. Assessing annotation transfer from genomics: Quantifying the relations between protein sequence, structure and function through traditional and probabilistic scores
17. Practical limits of function prediction
18. Completely uncoupled and perfectly coupled gene expression in repressible systems
19. Effect of overall feedback inhibition in unbranched biosynthetic pathways
20. The modeling of metabolic systems, structure, control and optimality
21. The game of the pentose phosphate cycle
22. Design metabolism: Alternative connectivities for the pentose phosphate pathway
23. Emergent properties of networks of biological signaling pathways
24. The large-scale organization of metabolic networks
25. The small world inside large metabolic networks
26. Size and form in efficient transportation networks
27. Protein family and fold occurrence in genomes: Power-law behaviour and evolutionary model