Naturlig immunitet - Första linjens försvar: Ny behandling mot infektioner och autoimmuna sjukdomar i sikte

Lakartidningen

Volumn 105, Issue 34, 2008, Pages 2254-2259

  Bergman, Peter ^a,b   Gudmundsson, Gudmundur H ^c   Agerberth, Birgitta ^b  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

^c UNIVERSITY OF ICELAND   (Iceland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA DEFENSIN; ANTIMICROBIAL CATIONIC PEPTIDE; BETA DEFENSIN; CATHELICIDIN; IMMUNOGLOBULIN RECEPTOR; MAGAININ DERIVATIVE;

ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BACTERIAL INFECTION; DRUG EFFECT; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOLOGY; INNATE IMMUNITY; METABOLISM; PHYSIOLOGY;

ALPHA-DEFENSINS; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; AUTOIMMUNE DISEASES; BACTERIAL INFECTIONS; BETA-DEFENSINS; CATHELICIDINS; HUMANS; IMMUNITY, NATURAL; IMMUNOHISTOCHEMISTRY; MAGAININS; RECEPTORS, IMMUNOLOGIC;

EID: 50849111787     PISSN: 00237205     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Odeberg H, Olsson I. Antibacterial activity of cationic proteins from human granulocytes. J Clin Invest. 1975;56:1118-24.
2. Steiner H, Hultmark D, Engstrom A, Bennich H, Boman HG. Sequence and specificity of two antibacterial proteins involved in insect immunity. Nature. 1981;292:246-8.
3. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature. 2002;415:389-95.
4. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124:783-801.
5. Ganz T. Defensins: antimicrobial peptides of innate immunity. Nat Rev Immunol. 2003;3:710-20.
6. Agerberth B, Gudmundsson GH. Host antimicrobial defence peptides in human disease. Curr Top Microbiol Immunol. 2006;306:67-90.
7. Oppenheim JJ, Tewary P, de la Rosa G, Yang D. Alarmins initiate host defense. Adv Exp Med Biol. 2007;601:185-94.
8. Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, et al. A beta-defensin mutation causes black coat color in domestic dogs. Science. 2007;318(5855):1418-23.
9. Salzman NH, Ghosh D, Huttner KM, Paterson Y, Bevins CL. Protection against enteric salmonellosis in transgenic mice expressing a human intestinal defensin. Na-ture. 2003;422:522-6.
10. Wehkamp J, Salzman NH, Porter E, Nuding S, Weichenthal M, Petras RE, et al. Reduced Paneth cell alpha defensins in ileal Crohn's disease. Proc Natl Acad Sci U S A. 2005;102:18129-34.
11. Raqib R, Sarker P, Bergman P, Ara G, Lindh M, Sack DA, et al. Improved outcome in shigellosis associated with butyrate induction of an endogenous peptide antibiotic. Proc Natl Acad Sci U S A. 2006;103:9178-83.
12. Islam D, Bandholtz L, Nilsson J, Wigzell H, Christensson B, Agerberth B, et al. Downregulation of bactericidal peptides in enteric infections: a novel immune escape mechanism with bacterial DNA as a potential regulator. Nat Med. 2001;7:180-5.
13. Chromek M, Slamova Z, Bergman P, Kovacs L, Podracka L, Ehren I, et al. The antimicrobial peptide ca-the-licidin protects the urinary tract against invasive bacterial infection. Nat Med. 2006;12:636-41.
14. Glaser R, Harder J, Lange H, Bartels J, Christophers E, Schroder JM. Antimicrobial psoriasin (S100A7) protects human skin from Escherichia coli infection. Nat Immunol. 2005;6:57-64.
15. Liu PT, Stenger S, Li H, Wenzel L, Tan BH, Krutzik SR, et al. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response. Science. 2006;311:1770-3.
16. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, et al. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Engl J Med. 2002;47:1151-60.
17. Lande R, Gregorio J, Facchinetti V, Chatterjee B, Wang YH, Homey B, et al. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature. 2007;449:564-9.
18. Peschel A, Sahl HG. The co-evolution of host cationic antimicrobial peptides and microbial resistance. Nat Rev Microbiol. 2006;4:529-36.
19. Casanova JL, Abel L. Primary immunodeficiencies: a field in its infancy. Science. 2007;317:617-9.