ATP modulates PTEN subcellular localization in multiple cancer cell lines

Human Molecular Genetics

Volumn 17, Issue 18, 2008, Pages 2877-2885

  Lobo, Glenn P ^a   Waite, Kristin A ^a,b   Planchon, Sarah M ^a   Romigh, Todd ^a   Houghton, Janet A ^a,b,c   Eng, Charis ^a,b,c  

^a LERNER RESEARCH INSTITUTE   (United States)

^b TAUSSIG CANCER INSTITUTE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ADENOSINE TRIPHOSPHATE DERIVATIVE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL LINEAGE; CELL TYPE; CELLULAR DISTRIBUTION; COLON CANCER; CONTROLLED STUDY; ENZYME REGULATION; HUMAN; HUMAN CELL; MULTIPLE CANCER; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REGULATORY MECHANISM; THYROID CARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOSINE TRIPHOSPHATE; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL NUCLEUS; COLORECTAL NEOPLASMS; HUMANS; PROTEIN TRANSPORT; PTEN PHOSPHOHYDROLASE; THYROID NEOPLASMS;

EID: 50849110465     PISSN: 09646906     EISSN: 14602083     Source Type: Journal    
DOI: 10.1093/hmg/ddn185     Document Type: Article

References (40)

1. Nelen, M.R., Padberg, G.W., Peeters, E.A., Lin, A.Y., van den Helm, B., Frants, R.R., Coulon, V., Goldstein, A.M., van Reen, M.M., Easton, D.F. et al. (1996) Localization of the gene for Cowdens disease to chromosome 10q22-23. Nat. Genet., 13, 114-116.
2. Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S.I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R. et al. (1997) PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science, 275, 1943-1947.
3. Steck, P.A., Pershouse, M.A., Jasser, S.A., Yung, W.K., Lin, H., Ligon, A.H., Langford, L.A., Baumgard, M.L., Hattier, T., Davis, T. et al. (1997) Identification of a candidate tumour suppressor gene. MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers. Nat. Genet., 15, 356-362.
4. Li, D.M. and Sun, H. (1997) TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta. Cancer Res., 57, 2124-2129.
5. Liaw, D., Marsh, D.J., Li, J., Dahia, P.L., Wang, S.I., Zheng, Z., Bose, S., Call, K.M., Tsou, H.C., Peacocke, M. et al. (1997) Germline mutations of the PTEN gene in Cowden's disease: An inherited breast and thyroid cancer syndrome. Nat. Genet., 16, 64-67.
6. Marsh, D.J., Coulon, V., Lunetta, K.L., Rocca-Serra, P., Dahia, P.L., Zheng, Z., Liaw, D., Caron, S., Duboue, B., Lin, A.Y. et al. Mutation spectrum and genotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum. Mol. Genet., 7, 507-515.
7. Zhou, X.P., Waite, K.A., Pilarski, R., Hampel, H., Fernandez, M.J., Bos, C., Dasouki, M., Feldman, G.L., Greenberg, L.A., Ivanovich, J. et al. Germline PTEN promoter mutations and deletions in Cowdens/ Bannayan-Riley-Ruvalcaba syndrome result in aberrant PTEN protein and dysfunction of the phosphoinositol-3-kinase/Akt pathway. Am. J. Hum. Genet., 73, 404-411.
8. Eng, C. (2003) PTEN: One gene, many syndromes. Hum. Mutat., 22 183-198.
9. Zbuk, K. and Eng, C. (2007) Cancer phenomics: RET and PTEN and illustrative models. Nat. Rev. Cancer, 7, 35-45.
10. Nassif, N.T., Lobo, G.P., Wu, X., Henderson, C.J., Morrison, C.D., Eng, C. and Segalov, E. (2004) PTEN mutations are common in sporadic microsatellite stable colorectal cancer. Oncogene, 23, 617-628.
11. Whang, Y.E., Wu, X., Suzuki, H., Reiter, R.E., Tran, C., Vessella, R.L., Said, J.W., Isaacs, W.B. and Sawyers, C.L. (1998) Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression. Proc. Natl. Acad. Sci. USA, 95, 5246-5250.
12. Perren, A., Weng, L.P., Boag, A.H., Ziebold, U., Thakore, K., Dahia, P.L., Komminoth, P., Lees, J.A., Mulligan, L.M., Mutter, G.L. and Eng, C. (1999) Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast. Am. J. Pathol., 155, 1253-1260.
13. Gimm, O., Perren, A., Weng, L.P., Marsh, D.J., Yeh, J.J., Ziebold, U., Gil, E., Hinze, R., Delbridge, L., Lees, J.A. et al. (2000) Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors. Am. J. Pathol., 156, 1693-1700.
14. Chung, J.H. and Eng, C. (2005) Nuclear-cytoplasmic partitioning of phosphatase and tensin homologue deleted on chromosome 10 (PTEN) differentially regulates the cell cycle and apoptosis. Cancer Res. 65, 8096-8100.
15. Ginn-Pease, M.E. and Eng, C. (2003) Increased nuclear phosphatase and tensin homologue deleted on chromosome 10 is associated with G0-G1 in MCF-7 cells. Cancer Res., 63, 282-286.
16. Shen, W.H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, P.P. and Yin, Y. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128, 157-170.
17. Chung, J.H., Ginn-Pease, M.E. and Eng, C. (2005) Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) has nuclear localization signal-like sequences for nuclear import mediated by major vault protein. Cancer Res., 65, 4108-4116.
18. Trotman, L.C., Wang, X., Alimonti, A., Chen, Z., Teruya-Feldstein, J., Yang, H., Pavletich, N.P., Carver, B.S., Cordon-Cardo, C., Erdjumenr-Bromage, H. et al. (2007) Ubiquitination regulates PTEN nuclear import and tumor suppression. Cell, 128, 141-156.
19. Planchon, S.M., Waite, K.W. and Eng, C. (2007) The nuclear affairs of PTEN. J. Cell Sci., 121, 249-253.
20. Denning, G., Jean-Joseph, B., Prince, C., Durden, D.L. and Vogt, P.K. (2007) A short N-terminal sequence of PTEN controls cytoplasmic localization and is required for suppression of cell growth. Oncogene 26, 3930-3940.
21. Liu, J.L., Sheng, X., Hortobagyi, Z.K., Mao, Z., Gallick, G.E. and Yung, W.K. (2005) Nuclear PTEN-mediated growth suppression is independent of Akt down-regulation. Mol. Cell. Biol., 25, 6211-6224.
22. Gil, A., Andres-Pons, A., Fernandez, E., Valiente, M., Torres, J., Cervera, J. and Pulido, R. (2006) Nuclear localization of PTEN by a Ran-dependent mechanism enhances apoptosis: Involvement of an N-terminal nuclear localization domain and multiple nuclear exclusion motifs. Mol. Biol. Cell, 17, 4002-4013.
23. Minaguchi, T., Waite, K.A. and Eng, C. (2006) Nuclear localization of PTEN is regulated by Ca(2+) through a tyrosil phosphorylation-independent conformational modification in major vault protein. Cancer Res., 66, 11677-11682.
24. Liu, J.L., Mao, Z., LaFortune, T.A., Alonso, M.M., Gallick, G.E., Fueyo, J. and Yung, W.K. (2007) Cell cycle-dependent nuclear export of phosphatase and tensin homologue tumor suppressor is regulated by the phosphoinositide-3-kinase signaling cascade. Cancer Res., 67 11054-11063.
25. Liu, F., Wagner, S., Campbell, R.B., Nickerson, J.A., Schiffer, C.A. and Ross, A.H. (2005) PTEN enters the nucleus by diffusion. J. Cell Biochem., 96, 221-234.
26. Pelicano, H., Martin, D.S., Xu, R.-H. and Huang, H. (2006) Glycolysis inhibition for anticancer treatment. Oncogene, 25, 4633-4646.
27. Maschek, G., Savaraj, N., Priebe, W., Braunschweiger, P., Hamilton, K., Tidmarsh, G.F., De Young, L.R. and Lampidis, T.J. (2004) 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res., 64, 31-34.
28. Martin, D.S., Bertino, J.R. and Koutcher, J.A. (2000) ATP depletion + pyrimidine depletion can markedly enhance cancer therapy: Fresh insight for a new approach. Cancer Res., 60, 6776-6783.
29. Zhang, X.D., Deslandes, E., Villedieu, M., Poulain, L., Duval, M., Gauduchon, P., Schwartz, L. and Icard, P. (2006) Effect of 2-deoxy-D-glucose on various malignant cells in vitro. Anticancer Res., 26, 3561-3566.
30. Zhu, Z., Jiang, W., McGinley, J.N. and Thompson, H.J. (2005) 2-Deoxyglucose as an energy restriction mimetic agent: Effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res., 65, 7023-7030.
31. Aft, R.L., Lewis, J.S., Zhang, F., Kim, J. and Welch, M.J. (2003) Enhancing targeted radiotherapy by copper(II)diacetyl-bis(N4-methylthiosemicarbazone) using 2-deoxy-D-glucose. Cancer Res., 63, 5496-5504.
32. Elstrom, R.L., Bauer, D.E., Buzzai, M., Kamauskas, R., Harris, M.H., Plas, DR., Zhuang, H., Cinalli, R.M., Alavi, A., Rudin, C.M. et al. (2004) Akt stimulates aerobic glycolysis in cancer cells. Cancer Res., 64, 3892-3899.
33. Karnauskas, R., Niu, Q., Talapatra, S., Plas, D.R., Grenne, M.E., Crispino, J.D. and Rudin, C.M. (2003) Bcl-x(L) and Akt cooperate to promote leukomogenesis in vivo. Oncogene, 22, 688-689.
34. Kose, S., Imamoto, N. and Yoneda, Y. (1999) Distinct energy requirement for nuclear import and export of importin β in living cells. FEBS Lett., 463, 327-330.
35. Schwoebel, E.D., Ho, T.H. and Moore, M.S. (2002) The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion. J. Cell Biol., 157, 963-974.
36. Hetzer, M. and Mattaj, I.W. (2000) An ATP-dependent, Rad-independent mechanism for nuclear import of the U1A and U2B" splicesome proteins. J. Cell Biol., 2, 293-303.
37. Jeyaraj, S.C., Dakhlallah, D., Hill, S.R. and Lee, B.S. (2006) Expression and distribution of HuR during ATP depletion and recovery in proximal tubule cells. Am. J. Physiol. Renal Physiol., 291, F1255-F1263.
38. Shank, L.C., Kelly, J.B., Gioeli, D., Yang, C.S., Spencer, A., Allison, L.A. and Paschal, B.M. (2008) Activation of the DNA-dependent protein kinase stimulates nuclear export of the androgen receptor in vitro. J. Biol. Chem., 283, 10568-10580.
39. Yamada, M., Mattaj, I.W. and Yoneda, Y. (2004) An ATP-dependent activity that releases RanGDP from NTF2. J. Biol. Chem., 279, 36228-36234.
40. Taylor, C.T. (2008) Mitochondria and cellular oxygen sensing and the HIF pathway. Biochem. J., 409, 19-26.