Investigations of the MceIJ-catalyzed posttranslational modification of the microcin E492 C-terminus: Linkage of ribosomal and nonribosomal peptides to form "Trojan horse" antibiotics

Biochemistry

Volumn 47, Issue 35, 2008, Pages 9289-9299

  Nolan, Elizabeth M ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANTIBIOTICS; CARBOXYLATION; CHLORINE COMPOUNDS; COMPLEXATION; DERIVATIVES; ESTERIFICATION; ESTERS; GLUCOSE; IRON COMPOUNDS; MACHINERY; ORGANIC COMPOUNDS; PORT TERMINALS; SUBSTRATES;

ESTER LINKAGES; GLYCOSYLATED; PROTEIN COMPLEXES; SIDEROPHORE;

AMINES;

ADENOSINE TRIPHOSPHATE; ALANINE; ANTIBIOTIC AGENT; BIOTIN; CARBOXYLIC ACID; CORTICOTROPIN DERIVATIVE; CYSTEINE; ENTEROCHELIN; ESTERASE; FLUORESCEIN; GLUCOSE; GLYCOSYLTRANSFERASE; HISTIDINE; HYDROXYL GROUP; MCEIJ PROTEIN; MICROCIN E492 C TERMINAL; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEIN DERIVATIVE; TROJAN HORSE ANTIBIOTIC; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DRUG CONJUGATION; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SPECIFICITY; ENZYME STRUCTURE; ENZYME SUBSTRATE; ENZYME SYNTHESIS; GENE CLUSTER; GLYCOSYLATION; IN VITRO STUDY; KINETICS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROCESSING; RIBOSOME; SITE DIRECTED MUTAGENESIS;

ADENOSINE TRIPHOSPHATE; ANTI-BACTERIAL AGENTS; BACTERIOCINS; CATALYSIS; ESCHERICHIA COLI; GLYCOSYLATION; KLEBSIELLA PNEUMONIAE; MUTAGENESIS, SITE-DIRECTED; PEPTIDE BIOSYNTHESIS, NUCLEIC ACID-INDEPENDENT; PEPTIDES; PROTEIN BIOSYNTHESIS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RIBOSOMES;

EQUIDAE; KLEBSIELLA PNEUMONIAE;

EID: 50849105102     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi800826j     Document Type: Article

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