Amitriptyline pretreatment preserves the antinociceptive effect of morphine in pertussis toxin-treated rats by lowering CSF excitatory amino acid concentrations and reversing the downregulation of glutamate transporters

Brain Research

Volumn 1232, Issue , 2008, Pages 61-69

  Lin, Jui An ^a,b   Tsai, Ru Yin ^c   Lin, Yueh Tzeng ^b   Lee, Meei Shyuan ^c   Cherng, Chen Hwan ^a   Wong, Chih Shung ^a   Tzeng, Jann Inn ^d  

^a TRI SERVICE GENERAL HOSPITAL   (Taiwan)

^b HUALIEN ARMED FORCES GENERAL HOSPITAL   (Taiwan)

^c NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^d CHI MEI MEDICAL CENTER   (Taiwan)

Author keywords

Amitriptyline; Excitatory amino acid; Glutamate transporter; Hyperalgesia; Pertussis toxin

Indexed keywords

AMITRIPTYLINE; ASPARTIC ACID; EXCITATORY AMINO ACID; EXCITATORY AMINO ACID TRANSPORTER; EXCITATORY AMINO ACID TRANSPORTER 1; GLUTAMATE TRANSPORTER; GLUTAMIC ACID; MORPHINE; PERTUSSIS TOXIN; VESICULAR GLUTAMATE TRANSPORTER 1;

AMINO ACID BRAIN LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CEREBROSPINAL FLUID; CONTROLLED STUDY; DIALYSATE; DOWN REGULATION; DRUG EFFECT; DRUG POTENTIATION; MALE; MICRODIALYSIS; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPINAL CORD DORSAL HORN; STATISTICAL SIGNIFICANCE;

AMINO ACID TRANSPORT SYSTEM X-AG; AMITRIPTYLINE; ANALGESICS, OPIOID; ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BLOTTING, WESTERN; DOWN-REGULATION; EXCITATORY AMINO ACIDS; HOT TEMPERATURE; MALE; MICRODIALYSIS; MORPHINE; PAIN; PERTUSSIS TOXIN; RATS; RATS, WISTAR; REACTION TIME; SPINAL CORD;

RATTUS; RATTUS NORVEGICUS;

EID: 50849090295     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2008.07.016     Document Type: Article

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