The structure of an open form of an E. coli mechanosensitive channel at 3.45 å resolution

Science

Volumn 321, Issue 5893, 2008, Pages 1179-1183

  Wang, Wenjian ^a   Black, Susan S ^b   Edwards, Michelle D ^b   Miller, Samantha ^b   Morrison, Emma L ^b   Bartlett, Wendy ^b   Dong, Changjiang ^a   Naismith, James H ^a   Booth, Ian R ^b  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

^b UNIVERSITY OF ABERDEEN   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIUM; CYTOLOGY; MECHANORECEPTION; MEMBRANE;

ARTICLE; CHANNEL GATING; CONFORMATION; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ESCHERICHIA COLI; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; TURGOR PRESSURE;

CELL MEMBRANE; CRYSTALLOGRAPHY, X-RAY; ELECTRIC CONDUCTIVITY; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; HYDROPHOBICITY; ION CHANNEL GATING; ION CHANNELS; MODELS, MOLECULAR; MUTANT PROTEINS; MUTATION; PATCH-CLAMP TECHNIQUES; PRESSURE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY;

ESCHERICHIA COLI;

EID: 50649125767     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1159262     Document Type: Article

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43. Our research was supported by the Wellcome Trust (grants GR077564MA and 040174), Medical Research Council (G0400277), Unilever (UK), and Biotechnology Biological Sciences Research Council (BBSRC) (BB/F003455/1). Structural biology used the facilities of the Scottish Structural Proteomics Facility funded by the Scottish Funding Council and BBSRC. We thank K. Johnson, T. Rasmussen, and F. Flett for their contributions to this work; D. Rees and R. Bass for advice on crystallization and for pre-release of x-ray intensities; and A. Leslie for a critical reading of the manuscript. Coordinates and data have been deposited in the Protein Data Bank (www.rcsb.org) with accession number 2vv5.