Molecular dissection of the human α2-macroglobulin subunit reveals domains with antagonistic activities in cell signaling

Journal of Biological Chemistry

Volumn 283, Issue 29, 2008, Pages 19904-19911

  Mantuano, Elisabetta ^a   Mukandala, Gatambwa ^a   Li, Xiaoqing ^a   Campana, W Marie ^a   Gonias, Steven L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; CHROMATOGRAPHIC ANALYSIS; CYTOLOGY; GENETIC ENGINEERING; GROWTH (MATERIALS); PEPTIDES; PHYSIOLOGY; PLASMAS; PROTEINS; SIGNALING;

ANTAGONISTIC ACTIVITIES; CELL PHYSIOLOGIES; CELLULAR MICROENVIRONMENT; CONFORMATIONAL CHANGES; DEGREE OF PENETRATIONS; DIFFERENT DOMAINS; DO-MAINS; FUSION PROTEINS; GROWTH FACTORS; IN CELLS; INTEGRATED ACTIVITIES; LOW DENSITY LIPOPROTEIN RECEPTORS; MACROGLOBULIN; MOLECULAR DISSECTIONS; MULTIPLE DOMAINS; NERVE GROWTH FACTORS; NEURITE OUTGROWTHS; PC12 CELLS; PROTEASE INHIBITORS; REGULATORY PROTEINS; SCHWANN CELLS; SIGNALING ACTIVITIES;

CELL GROWTH;

ALPHA 2 MACROGLOBULIN; GLUTATHIONE TRANSFERASE; GROWTH FACTOR; HYBRID PROTEIN; HYBRID PROTEIN 3; HYBRID PROTEIN 6; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR BETA SUBUNIT; NEUROMODULIN; PROTEIN KINASE B; PROTEIN SUBUNIT; REGULATOR PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL FUNCTION; CELL GROWTH; CELL ISOLATION; CELL MEMBRANE; CELL STRAIN; CHROMATOGRAPHY; CONTROLLED STUDY; DISSECTION; ENZYME ACTIVATION; GENE SILENCING; HETEROZYGOTE DETECTION; INCUBATION TIME; MICROENVIRONMENT; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; MUTATION; NEURITE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM; SCHWANN CELL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DRUG EFFECT; GENETICS; HUMAN; METABOLISM; MOLECULAR WEIGHT; MOUSE; RAT;

ALPHA-MACROGLOBULINS; ANIMALS; CELL LINE; HUMANS; LDL-RECEPTOR RELATED PROTEIN 1; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MOLECULAR WEIGHT; MUTATION; NEURITES; PROTEIN BINDING; PROTEIN SUBUNITS; RATS; SCHWANN CELLS; SIGNAL TRANSDUCTION;

EID: 50649110085     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M801762200     Document Type: Article

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