Rat α1-macroglobulin enhances nerve growth factor-promoted neurite outgrowth, TrkA phosphorylation, and gene expression of pheochromocytoma PC12 cells

Journal of Neurochemistry

Volumn 74, Issue 1, 2000, Pages 81-91

  Lee, Paek Gyu ^a   Koo, Peter ^a  

^a Northeastern Ohio Medical University   (United States)

Author keywords

Macroglobulins; Delayed response genes; Immediate early genes; Nerve growth factor receptor; Neurite promoting factor; Signal transduction

Indexed keywords

ALPHA 2 MACROGLOBULIN; MACROGLOBULIN; NERVE GROWTH FACTOR; TYROSINE KINASE RECEPTOR; CARRIER PROTEIN; DNA BINDING PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; EGR1 PROTEIN, RAT; IMMEDIATE EARLY PROTEIN; MEMBRANE PROTEIN; PROTEIN C JUN; PROTEIN TYROSINE KINASE A; SEROTONIN; STMN2 PROTEIN, RAT; STROMELYSIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; ENZYME INHIBITION; GENE EXPRESSION; IMMEDIATE EARLY GENE; NERVE FIBER GROWTH; NONHUMAN; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; ANIMAL; CELL STRAIN; DRUG EFFECT; GENETICS; METABOLISM; NEURITE; PHOSPHORYLATION; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ALPHA-MACROGLOBULINS; ANIMALS; CARRIER PROTEINS; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; GENE EXPRESSION; IMMEDIATE-EARLY PROTEINS; MATRIX METALLOPROTEINASE 3; MEMBRANE PROTEINS; NERVE GROWTH FACTOR; NERVE GROWTH FACTORS; NEURITES; PC12 CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-JUN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, TRKA; SEROTONIN; TRANSCRIPTION FACTORS;

EID: 0033621567     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2000.0740081.x     Document Type: Article

References (79)

1. Aigner L. and Caroni R. (1995) Absence of persistent spreading, branching and adhesion in GAP-43-depleted growth cones. J. Cell Biol. 128, 647-660.
2. Banks R. E., Evans S. W., Van Leuven F., Alexander D., McMahon M. J., and Whicher J. T. (1990) Measurement of the 'fast' or complexed form of alpha-2-macroglobulin in biological fluids using a sandwich enzyme immunoassay. J. Immunol. Methods 126, 13-20.
3. Banks R. E., Evans S. W., Alexander D., Van Leuven F., Whicher J. T., and McMahon M. J. (1991) Alpha-2-macroglobulin state in acute pancreatitis. Raised values of alpha-2-macroglobulin-protease complexes in severe and mild attacks. Gut 32, 430-434.
4. Barde Y. A. (1989) Trophic factors and neuronal survival. Neuron 2, 1525-1534.
5. Barrett A. J., Brown M. A., and Sayers C. A. (1979) The electrophoretically 'slow' and 'fast' forms of the alpha-2-macroglobulin molecule. Biochem. J. 181, 401-418.
6. 2-macroglobulin indicate an acute-phase state in Alzheimer's disease cortices. FEBS Lett. 285, 111-114.
7. Boulton T. G., Nye S. H., Robbins D. J., Ip N. Y., Radziejewska E., Morgenbesser S. D., DePinho R. A., Panayotatas N., Cobb M. H., and Yancopoulos G. D. (1991) Erks: a family of protein-serine/ threonine kinases that are activated and tyrosine phosphorylated in response to insulin and NGF. Cell 65, 663-675.
8. Breathnach R. L., Matrisian L. M., Gesnel M. C., Staub A., and Leroy P. (1987) Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Nucleic Acids Res. 15, 1139-1151.
9. Brodie C. and Gelfand E. W. (1992) Functional nerve growth factor receptors on human B lymphocytes. Interaction with IL-2. J. Immunol. 148, 3492-3497.
10. Cavus I., Koo P. H., and Teyler T. J. (1996) Inhibition of long-term potentiation development in rat hippocampal slice by alpha-2-macroglobulin, an acute-phase protein in the brain. J. Neurosci. Res. 43, 282-288.
11. Chen R. H., Sarnecki C., and Blenis J. (1992) Nuclear localization and regulation of erk- and rsk-encoded protein kinases. Mol. Cell. Biol. 12, 915-927.
12. Chin J. R. and Werb Z. (1997) Matrix metalloproteinases regulate morphogenesis, migration and remodeling of epithelium, tongue skeletal muscle and cartilage in the mandibular arch. Development 124, 1519-1530.
13. Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
14. Christy B. A., Lau L. F., and Nathans D. (1988) A gene activated in mouse 3T3 cells by serum growth factors encodes a protein with "zinc finger" sequences. Proc. Natl. Acad. Sci. USA 85, 7857-7861.
15. Di Paolo G., Lutjens R., Osen-Sand A., Sobel A., Catsicas S., and Grenningloh G. (1997) Differential distribution of stathmin and SCG10 in developing neurons in culture. J. Neurosci. Res. 50, 1000-1009.
16. Ehrhard P. B., Erb P., Graumann U., and Otten U. (1994) Expression of functional trk tyrosine kinase receptors after T cell activation. J. Immunol. 152, 2705-2709.
17. 2-macroglobulin receptor. Biochemistry 28, 1406-1412.
18. Escandon E. and Chao M. V. (1990) Identification of high- and low-affinity NGF receptors during development of the chicken central nervous system. Dev. Biol. 142, 293-300.
19. Gillen C., Korfhage C., and Muller H. W. (1997) Gene expression in nerve regeneration. Neuroscientist 3, 112-122.
20. 2-macroglobulins of rat serum. Biochem. J. 159, 643-650.
21. Greenberg M. E., Greene L. A., and Ziff E. B. (1985) Nerve growth factor and epidermal growth factor induce rapid transient changes in proto-oncogene transcription in PC12 cells. J. Biol. Chem. 260, 14101-14110.
22. Greene L. A. and Shooter E. M. (1980) The nerve growth factor: biochemistry, synthesis, and mechanism of action. Annu. Rev. Neurosci. 3, 353-402.
23. Greene L. A. and Tischler A. S. (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73, 2424-2428.
24. Hannan A. J., Henke R. C., Weinberg R. P., Sentry J. W., and Jeffrey P. L. (1996) Differential induction and intracellular localization of SCG10 messenger RNA is associated with neuronal differentiation. Neuroscience 72, 899-900.
25. 2-macroglobulin. J. Neurochem. 71, 213-220.
26. Hu Y.-Q., Dluzen D. E., and Koo P. H. (1994) Intracranial infusion of monoamine-activated alpha-2-macroglobulin decreases dopamine concentrations within the rat caudate putamen. J. Neurosci. Res. 38, 531-537.
27. 2-macroglobulin. J. Neurosci. Res. 43, 71-77.
28. 2-macroglobulin. J. Neurosci. Res. 51, 541-550.
29. Jespersen M. H., Jensen J., Rasmussen L. H., Ejlersen E., Moller-Petersen J., and Sperling-Petersen H. U. (1993) The reference range for complexed alpha-2-macroglobulin human plasma: development of a new enzyme linked in immunosorbent assay (ELISA) for quantitation of complexed alpha-2-macroglobulin. Scand. J. Clin. Lab. Invest. 53, 639-648.
30. Jing S., Tapley P., and Barbicid M. (1992) Nerve growth factor mediates signal transduction through trk homodimer receptors. Neuron 9, 1067-1079.
31. Johnson D., Lanahan A., Buck C. R., Sehgal A., Morgan C., Mercer E., Bothwell M., and Chao M. (1986) Expression and structure of the human NGF receptor. Cell 47, 545-554.
32. Johnson P. W., Abramow-Newerly W., Seilheimer B., Sadoul R., Tropak M. B., Arquint M., Dunn R. I., Schachner M., and Roder J. C. (1989) Recombinant myelin-associated glycoprotein confers neural adhesion and neurite outgrowth function. Neuron 3, 377-385.
33. Kaplan D. R. and Miller F. D. (1997) Signal transduction by the neurotrophin receptors. Curr. Opin. Cell Biol. 9, 213-221.
34. Kaplan D. R., Martin-Zanca D., and Parada L. F. (1991) Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF. Nature 350, 158-160.
35. Kawamoto K., Okada T., Kannan Y., Ushino H., Matsumoto M., and Matsuda H. (1995) Nerve growth factor prevents apoptosis of rat peritoneal mast cells through the trk proto-oncogene receptor. Blood 86, 4638-4644.
36. Kerppola T. K. and Curran T. (1991) Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: implications for transcription factor cooperativity. Cell 66, 317-326.
37. Kodelja V., Heisig M., Northemann W., Heinrich P. C., and Zimmermann W. (1986) Alpha-2-macroglobulin gene expression during rat development studied by in situ hybridization. EMBO J. 5, 3151-3156.
38. Koo P. H. and Liebl D. J. (1992) Inhibition of nerve growth factor-stimulated neurite outgrowth by methylamine-moditied alpha-2-macroglobulin. J. Neurosci. Res. 31, 678-692.
39. Koo P. H. and Qiu W. S. (1994) Monoamine-activated alpha-2-macroglobulin binds trk receptor and inhibits nerve growth factor-stimulated trk phosphorylation and signal transduction. J. Biol. Chem. 269, 5369-5376.
40. Koo P. H. and Stach R. W. (1989) Interaction of nerve growth factor with murine alpha-macroglobulin. J. Neurosci. Res. 22, 247-261.
41. Koo P. H., Lee P. G., Liebl D. J., and Witt W. C. (1996) Rat alpha-1-and alpha-2-macroglobulin respectively enhances and inhibits trkA activation and sciatic nerve regeneration. Neuroimmunomodulation 3, 186.
42. Kristensen T., Moestrup S. K., Gliemann J., Bendtsch L., Sand O., and Sottrup-Jensen L. (1990) Evidence that the newly cloned low-density lipoprotein receptor-related protein (LRP) is the alpha-2-macroglobulin receptor. FEBS Lett. 276, 151-155.
43. 2-macroglobulin in their effect on NGF-promoted induction of TrkA autophosphorylation, immediate early genes, and delayed response genes. Soc. Neurosci. Abstr. 24, 291.
44. Lemaire P., Vesque C., Schmitt J., Stunnenberg H., Frank R., and Charnay P. (1990) The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol. Cell. Biol. 10, 3456-3467.
45. Levi-Montalcini R. (1987) Nerve growth factor: thirty years later. Science 237, 1154-1162.
46. 2-macroglobulin homologues. Ph.D. Dissertation, Kent State University/Northeastern Ohio Universities College of Medicine.
47. Liebl D. J. and Koo P. H. (1993a) Comparative binding of neurotrophins (NT-3, CNTF and NGF) and various cytokines to alpha-2-macroglobulin. Biochem. Biophys. Res. Commun. 193, 1255-1261.
48. Liebl D. J. and Koo P. H. (1993b) Serotonin-activated alpha-2-macroglobulin inhibits neurite outgrowth and survival of embryonic sensory and cerebral cortical neurons. J. Neurosci. Res. 35, 170-182.
49. Liebl D. J. and Koo P. H. (1994) Monoamine-activated alpha-2-macroglobulin inhibits choline acetyltransferase of embryonic basal forebrain neurons and reversal of the inhibition by NGF and BDNF but not NT-3. J. Neurosci. Res. 38, 407-414.
50. Lonberg-Holm K., Reed D. L., Robert R. C. and Damato-McCabe D. (1987) Three high molecular weight protease inhibitors of rat plasma. Reactions with trypsin. J. Biol. Chem. 262, 4844-4853.
51. Machida C. M., Rodland K. D., Matrisian L., Magun B. E., and Ciment G. (1989) NGF induction of the gene encoding the protease transin accompanies neuronal differentiation in PC12 cells. Neuron 2, 1587-1596.
52. Maroder M., Bellavia D., Meco D., Napolitano M., Stigliano A., Alesse E., Vacca A., Giannini G., Frati L., Gulino A., and Screpanti T. (1996) Expression of trkB neurotrophin receptor during T cell development. Role of brain-derived neurotrophic factor in immature thymocyte. J. Immunol. 157, 2864-2872.
53. Matsuda S., Saito H., and Nishiyama N. (1990) Basic fibroblast growth factor suppressed the enhancement of choline acetyltransferase activity induced by nerve growth factor. Neurosci. Lett. 114, 69-74.
54. Milbrandt J. (1987) A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238, 797-799.
55. Milbrandt J. (1988) Nerve growth factor induces a gene homologous to the glucocotticoid receptor gene. Neuron 1, 183-188.
56. 1M signaling receptor. J. Biol. Chem. 269, 18303-18306.
57. Morgan B., Thorpe L. W., Marchetti D., and Perez-Polo J. R. (1989) Expression of nerve growth factor receptors by human peripheral blood mononuclear cells. J. Neurosci. Res. 23, 41-45.
58. Morrison R. S., Sharma A., De Vellis J., and Bradshaw R. A. (1986) Basic fibroblast growth factor supports the survival of cerebral cortical neurons in primary culture. Proc. Natl. Acad. Sci. USA 83, 7537-7541.
59. Mukhopadhyay G., Doherty P., Walsh F. S., Crocker P. R., and Filbin M. T. (1994) A novel role for myelin-associated glycoprotein as an inhibitor of axonal regeneration. Neuron 13, 757-767.
60. Okubo H., Miyanaga O., Nagano M., Ishibashi H., Kudo J., Ikuta T., and Shibata K. (1981) Purification and immunological determination of alpha-2-macroglobulin in serum from injured rats. Biochim. Biophys. Acta 668, 257-267.
61. Rabizadeh S., Oh J., Zhong L. T., Yang J., Bitler C. M., Butcher L. L., and Bredesen D. E. (1993) Induction of apoptosis by the low-affinity NGF receptor. Science 261, 345-348.
62. Riederer B. M., Pellier V., Antonsson B., Di Paolo G., Stimpson S. A., Lutjens R., Catsicas S., and Grenningloh G. (1997) Regulation of microtubule dynamics by the neuronal growth-associated protein SCG10. Proc. Natl. Acad. Sci. USA 94, 741-745.
63. Rivera V. M., Miranti C. K., Misra R. P., Ginty D. D., Chen R. H., Blenis J., and Greenberg M. E. (1993) A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol. Cell. Biol. 13, 6260-6273.
64. Schaeufele J. T. and Koo P. H. (1982) Structural comparison of rat alpha-1- and alpha-2-macroglobulins. Biochim. Biophys. Res. Commun. 108, 1-7.
65. Seckel B. R. (1990) Enhancement of peripheral nerve regeneration. Muscle Nerve 13, 785-800.
66. Segal R. A. and Greenberg M. E. (1996) Intracellular signalling pathways activated by neurotrophic factors. Annu. Rev. Neurosci. 19, 463-489.
67. Silver X. Q. (1999) Studies on the binding of rat alpha-macroglobulins to neurotrophic factors and placental protein 14 (pp14) and the effect of these alpha-macroglobulins on the immunosuppressive activity of placental protein 14. M.S. Thesis, Kent State University/Northeastern Ohio Universities College of Medicine.
68. Sottrup-Jensen L. (1989) α-Macroglobulins: structure, shape, and mechanism of proteinase complex formation. J. Biol. Chem. 264, 11539-11542.
69. Stein R., Mori N., Matthews K., Lo L. C., and Anderson D. J. (1988) The NGF-inducible SCG10 mRNA encodes a novel membrane-bound protein present in growth cones and abundant in developing neurons. Neuron 1, 463-476.
70. Steinbuch M., Pejaudier L., Quentin M., and Martin V. (1968) Molecular alteration of alpha-2-macroglobulin by aliphatic amines. Biochim. Biophys. Acta 154, 228-231.
71. 2-macroglobulin immunoreactivity in cortex and hippocampus of Alzheimer's disease patients. Lab. Invest. 66, 223-230.
72. Strickland D. K., Ashcom J. D., Williams S., Burgess W. H., Migliorini M., and Argraves W. S. (1990) Sequence identity between the alpha-2-macroglobulin receptor and low-density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor. J. Biol. Chem. 265, 17401-17404.
73. Strittmatter S. M., Igarashi M., and Fishman M. C. (1994) GAP-43 amino terminal peptides modulate growth cone morphology and neurite outgrowth. J. Neurosci. 14, 5503-5513.
74. Swenson R. P. and Howard J. B. (1979) Characterization of alkylamine-sensitive site in alpha-2-macroglobulin. Proc. Natl. Acad. Sci. USA 76, 4313-4316.
75. Szeberenyi J. (1998) Normal stimulation of the synthesis, phosphorylation and DNA binding activity of c-Fos and Zif268 proteins by nerve growth factor is not sufficient to mediate neuronal differentiation of PC12 cells. Mol. Cell. Biochem. 189, 71-77.
76. Varon S. and Hagg T. (1993) Models to evaluate effects of neurotrophic factors on axonal regeneration, in Neuromethods, Vol. 25 (Boulton A. A., Baker G. B., and Hefti F., eds). pp. 277-289. Humana Press, Totowa, New Jersey.
77. Walicke P. A., Cowan W. M., Ueno N., Baird A., and Guillemin R. (1986) Fibroblast growth factor promotes survival of dissociated hippocampal neurons and enhances neurite extension. Proc. Natl. Acad. Sci. USA 83, 3012-3016.
78. Wolf B. B. and Gonias S. L. (1994) Neurotrophin binding to human alpha-2-macroglobulin under apparent equilibrium conditions. Biochemistry 33, 11270-11277.
79. Wu B. Y., Fodor E. J., Edwards R. H., and Rutter W. J. (1989) Nerve growth factor induces the proto-oncogene c-jun in PC12 cells. J. Biol. Chem. 264, 9000-9003.