Limited mutations in full-length tetrameric human α2- macroglobulin abrogate binding of platelet-derived growth factor-BB and transforming growth factor-β1

Journal of Biological Chemistry

Volumn 281, Issue 25, 2006, Pages 17061-17068

  Arandjelovic, Sanja ^a   Van Sant, Cristina L ^b   Gonias, Steven L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONFORMATIONS; MACROMOLECULES; MATHEMATICAL MODELS; NUCLEIC ACID SEQUENCES; RECEPTION QUALITY;

LENGTH TETRAMERIC HUMAN MACROGLOBULIN ABROGATE; LIPOPROTEIN RECEPTOR-RELATED PROTEIN (LRP-1); MUTATIONS; SYNTHETIC PEPTIDES;

MUTAGENESIS;

ALPHA 2 MACROGLOBULIN; ASPARAGINASE; GLUTAMIC ACID; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BB; PROTEIN DERIVATIVE; PROTEIN LRP 1; PROTEIN SUBUNIT; PROTEINASE; TETRAMER; THIOESTER; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN K 562; CHEMICAL BOND; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; GENE MUTATION; HUMAN; HUMAN CELL; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN ENGINEERING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TARGETING;

ALPHA-MACROGLOBULINS; AMINO ACID SEQUENCE; ANIMALS; HUMANS; K562 CELLS; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PLATELET-DERIVED GROWTH FACTOR; PROTEIN BINDING; PROTEIN CONFORMATION; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 33745192078     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602217200     Document Type: Article

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