Using distinct molecular signatures of human monocytes and dendritic cells to predict adjuvant activity and pyrogenicity of TLR agonists

Medical Microbiology and Immunology

Volumn 197, Issue 4, 2008, Pages 369-379

  Kamgang, Richard Kenmoe ^c   Ramos, Inês ^b   Rodrigues Duarte, Lurdes ^b   Ghielmetti, Mascia ^c   Freudenberg, Marina ^d   Dahinden, Clemens ^e   Padovan, Elisabetta ^a,b  

^a Lisbon Medical School   (Portugal)

^b INSTITUTO GULBENKIAN DE CIÊNCIA   (Portugal)

^c UNIVERSITY OF BERN   (Switzerland)

^d MAX PLANCK INSTITUTE OF IMMUNOBIOLOGY AND EPIGENETICS   (Germany)

^e Astronomical Institute of Berne   (Switzerland)

Author keywords

Adjuvant screening; Dendritic cell; Human; Monocytes; Th1 cells

Indexed keywords

ADJUVANT; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPID A; LIPOPEPTIDE; POLYINOSINIC POLYCYTIDYLIC ACID; PYROGEN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 2 AGONIST; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 4 AGONIST; TOLL LIKE RECEPTOR AGONIST; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ADJUVANT THERAPY; ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; LYMPHOCYTE PROLIFERATION; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE; UPREGULATION;

ADJUVANTS, IMMUNOLOGIC; CD4-POSITIVE T-LYMPHOCYTES; CELL PROLIFERATION; CELLS, CULTURED; CHEMOKINE CXCL10; DENDRITIC CELLS; GENE EXPRESSION PROFILING; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPID A; LYMPHOCYTE ACTIVATION; MONOCYTES; POLY I-C; TOLL-LIKE RECEPTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 50649101706     PISSN: 03008584     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00430-008-0081-6     Document Type: Article

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