Synthetic bacterial lipopeptide analogs: Structural requirements for adjuvanticity

Immunobiology

Volumn 210, Issue 2-4, 2005, Pages 211-215

  Ghielmetti, Mascia ^a   Reschner, Anca ^b   Zwicker, Marianne ^a   Padovan, Elisabetta ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b UNIVERSITY HOSPITAL BASEL   (Switzerland)

Author keywords

Adjuvant; CD4; CD8; Dendritic cell; Pam3< inf>CysSerLys4< inf>; TNF

Indexed keywords

ADJUVANT; BACTERIAL VACCINE; HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; INFLUENZA VACCINE; LIPOPEPTIDE; LIPOPROTEIN; RECOMBINANT VACCINE; SUBUNIT VACCINE; TOLL LIKE RECEPTOR 2; TUMOR NECROSIS FACTOR ALPHA;

ADJUVANT THERAPY; CELLULAR IMMUNITY; DRUG DESIGN; DRUG SYNTHESIS; EXPERIMENTAL DESIGN; HUMAN; IMMUNE RESPONSE; IMMUNOGENICITY; IMMUNOMODULATION; IN VIVO STUDY; INNATE IMMUNITY; LIPOPROTEIN SYNTHESIS; MOLECULAR BIOLOGY; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; REVIEW; T LYMPHOCYTE;

EID: 22644438869     PISSN: 01712985     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.imbio.2005.05.015     Document Type: Review

References (26)

1. L. Alexopoulou V. Thomas M. Schnare Y. Lobet J. Anguita R.T. Schoen R. Medzhitov E. Fikrig R.A. Flavell Hyporesponsiveness to vaccination with Borrelia burgdorferi OspA in humans and in TLR1- and TLR2-deficient mice Nat. Med. 8 2002 878-884
2. W. Baier N. Masihi M. Huber P. Hoffmann W.G. Bessler Lipopeptides as adjuvants and immunostimulants in mucosal immunization Immunobiology 201 2000 391-405
3. J.A. Berzofsky J.D. Ahlers I.M. Belyakov Strategies for designing and optimizing new generation vaccines Nat. Rev. Immunol. 1 2001 209-219
4. W.G. Bessler L. Heinevetter K.H. Wiesmuller G. Jung W. Baier M. Huber A.R. Lorenz U.V. Esche K. Mittenbuhler P. Hoffmann Bacterial cell wall components as immunomodulators I. Lipopeptides as adjuvants for parenteral and oral immunization Int. J. Immunopharmacol. 19 1997 547-550
5. W.G. Bessler K. Mittenbuhler U. Esche M. Huber Lipopeptide adjuvants in combination treatment Int. Immunopharmacol. 3 2003 1217-1224
6. V. Braun K. Rehn Chemical characterization, spatial distribution and function of a lipoprotein (murein-lipoprotein) of the E. coli cell wall: the specific effect of trypsin on the membrane structure Eur. J. Biochem. 10 1969 425-438
7. U. Buwitt-Beckmann H. Heine K.H. Wiesmuller G. Jung R. Brock S. Akira A.J. Ulmer Toll-like receptor 6-independent signaling by diacylated lipopeptides Eur. J. Immunol. 35 2005 282-289
8. K. Deres H. Schild K.H. Wiesmuller G. Jung H.G. Rammensee In vivo priming of virus-specific cytotoxic T lymphocytes with synthetic lipopeptide vaccine Nature 342 1989 561-564
9. Ghielmetti, M., Zwicker, M., Ghielmetti, T., Simon, M.M., Villiger, P.M., Padovan, E., 2005. Synthetic bacterial lipopeptide analogs facilitate naive CD4+ T cell differentiation and enhance antigen-specific HLA-II restricted responses. Eur. J. Immunol., in press.
10. P. Hoffmann S. Heinle U.F. Schade H. Loppnow A.J. Ulmer H.D. Flad G. Jung W.G. Bessler Stimulation of human and murine adherent cells by bacterial lipoprotein and synthetic lipopeptide analogues Immunobiology 177 1988 158-170
11. A. Iwasaki R. Medzhitov Toll-like receptor control of the adaptive immune responses Nat. Immunol. 5 2004 987-995
12. D. Jarrossay G. Napolitani M. Colonna F. Sallusto A. Lanzavecchia Specialization and complementarity in microbial molecule recognition by human myeloid and plasmacytoid dendritic cells Eur. J. Immunol. 31 2001 3388-3393
13. M. Manukyan K. Triantafilou M. Triantafilou A. Mackie N. Nilsen T. Espevik K.-H. Wiesmüller A.J. Ulmer H. Heine Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1 Eur. J. Immunol. 35 2005 911-921
14. D. Marciani Vaccine adjuvants: Role and mechanisms of action in vaccine immunogenicity Drug Discov. Today 8 2003 934-935
15. D.M. Pardoll Spinning molecular immunology into successful immunotherapy Nat. Rev. Immunol. 2 2002 227-238
16. R. Rappuoli From Pasteur to genomics: Progress and challenges in infectious diseases Nat. Med. 10 2004 1177-1185
17. A. Reschner A. Moretta R. Landmann M. Heberer G.C. Spagnoli E. Padovan The ester-bonded palmitoyl side chains of Pam3 CysSerLys4 lipopeptide account for its powerful adjuvanticity to HLA class I-restricted CD8+ T lymphocytes Eur. J. Immunol. 33 2003 2044-2052
18. H. Schild M. Norda K. Deres K. Falk O. Rotzschke K.H. Wiesmuller G. Jung H.G. Rammensee Fine specificity of cytotoxic T lymphocytes primed in vivo either with virus or synthetic lipopeptide vaccine or primed in vitro with peptide J. Exp. Med. 174 1991 1665-1668
19. N.W. Schroder H. Heine C. Alexander M. Manukyan J. Eckert L. Hamann U.B. Gobel R.R. Schumann Lipopolysaccharide binding protein binds to triacylated and diacylated lipopeptides and mediates innate immune responses J. Immunol. 173 2004 2683-2691
20. M. Singh D.T. O'Hagan Recent advances in vaccine adjuvants Pharm. Res. 19 2002 715-728
21. R. Spohn U. Buwitt-Beckmann R. Brock G. Jung A.J. Ulmer K.H. Wiesmuller Synthetic lipopeptide adjuvants and Toll-like receptor 2-structure-activity relationships Vaccine 22 2004 2494-2499
22. U. van der Esche M. Ayoub S.D. Pfannes M.R. Muller M. Huber K.H. Wiesmuller T. Loop M. Humar K.F. Fischbach M. Strunkelnberg P. Hoffmann W.G. Bessler K. Mittenbuhler Immunostimulation by bacterial components: I. Activation of macrophages and enhancement of genetic immunization by the lipopeptide P3CSK4 Int. J. Immunopharmacol. 22 2000 1093-1102
23. A. Visintin A. Mazzoni J.H. Spitzer D.H. Wyllie S.K. Dower D.M. Segal Regulation of Toll-like receptors in human monocytes and dendritic cells J. Immunol. 166 2001 249-255
24. A. Vitiello G. Ishioka H.M. Grey R. Rose P. Farness R. LaFond L. Yuan F.V. Chisari J. Furze R. Bartholomeuz R.W. Chesnut Development of a lipopeptide-based therapeutic vaccine to treat chronic HBV infection. I. Induction of a primary cytotoxic T lymphocyte response in humans J. Clin. Invest. 95 1995 341-349
25. F. Wiedemann R. Link K. Pumpe U. Jacobshagen H.E. Schaefer K.H. Wiesmuller R.P. Hummel G. Jung W. Bessler T. Boltz Histopathological studies on the local reactions induced by complete Freund's adjuvant (CFA), bacterial lipopolysaccharide (LPS), and synthetic lipopeptide (P3C) conjugates J. Pathol. 164 1991 265-271
26. K.H. Wiesmuller B. Fleckenstein G. Jung Peptide vaccines and peptide libraries Biol. Chem. 382 2001 571-579