Construction, expression and activities of three active variants of human uridine diphosphate glucuronic acid transferase 2B7

Chinese Journal of Pharmacology and Toxicology

Volumn 22, Issue 4, 2008, Pages 274-283

  Yuan, Ling Min ^a   Chen, Jing ^a   Zeng, Su ^a  

^a ZHEJIANG UNIVERSITY   (China)

Author keywords

Mutant proteins; Uridine diphosphate glucuronic acid transferase

Indexed keywords

ENZYME VARIANT; GLUCURONOSYLTRANSFERASE 2B7; GLUCURONOSYLTRANSFERASE 2B7 2; GLUCURONOSYLTRANSFERASE 2B7 5; GLUCURONOSYLTRANSFERASE 2B7 71S; MUTANT PROTEIN; RECOMBINANT ENZYME; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ARTICLE; BACULOVIRUS EXPRESSION SYSTEM; DRUG ACTIVATION; DRUG SYNTHESIS; ENZYME ACTIVITY; ESCHERICHIA COLI; FLUOROMETRY; GENETIC TRANSFECTION; LEPIDOPTERA; NONHUMAN; PROTEIN EXPRESSION; WILD TYPE;

SPODOPTERA FRUGIPERDA;

EID: 50449108087     PISSN: 10003002     EISSN: None     Source Type: Journal    
DOI: 10.3867/j.issn.1000-3002.2008.04.006     Document Type: Article

References (34)

1. Radominska-Pandya A, Czernik PJ, Little JM, Battaglia E, Mackenzie PI. Structural and functional studies of UDP-glucuronosyltransferases[J]. Drug Metab Rev, 1999, 31(4):817-899.
2. Sawyer MB, Innocenti F, Das S, Cheng C, Ramírez J, Pantle-Fisher FH, et al. A pharmacogenetic study of uridine diphosphate- glucuronosyltransferase 2B7 in patients receiving morphine[J]. Clin Pharmacol Ther, 2003, 73(6):566-574.
3. Saeki M, Saito Y, Jinno H, Tanaka-Kagawa T, Ohno A, Ozawa S, et al. Single nucleotide polymorphisms and haplotype frequencies of UGT2B4 and UGT2B7 in a Japanese population[J]. Drug Metab Dispos, 2004, 32(9):1048-1054.
4. Lin GF, Guo WC, Chen JG, Qin YQ, Golka K, Xiang CQ, et al. An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine-exposed workers in China[J]. Toxicol Sci, 2005, 85(1):502-506.
5. Coffman BL, King CD, Rios GR, Tephly TR. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)[J]. Drug Metab Dispos, 1998, 26(1):73-77.
6. Saito K, Moriya H, Sawaguchi T, Hayakawa T, Nakahara S, Goto A, et al. Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects[J]. Clin Biochem, 2006, 39(3):303-308.
7. Tukey RH, Strassburg CP. Human UDP-glucuronosyltransferases: metabolism, expression, and disease[J]. Annu Rev Pharmacol Toxicol, 2000, 40:581-616.
8. King CD, Rios GR, Green MD, Tephly TR. UDP-glucuronosyltransferases[J]. Curr Drug Metab, 2000, 1(2):143-161.
9. Donato MT, Jiménez N, Castell JV, Gómez-Lechón MJ. Fluorescence-based assays for screening nine cytochrome P450 (P450) activities in intact cells expressing individual human P450 enzymes[J]. Drug Metab Dispos, 2004, 32(7):699-706.
10. Uchaipichat V, Mackenzie PI, Guo XH, Gardner-Stephen D, Galetin A, Houston JB, et al. Human UDP-glucuronosyltransferases: isoform selectivity and kinetics of 4-methylumbelliferone and 1-naphthol glucuronidation, effects of organic solvents, and inhibition by diclofenac and probenecid[J]. Drug Metab Dispos, 2004, 32(4):413-423.
11. Houston JB. Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance[J]. Biochem Pharmacol, 1994, 47(9):1469-1479.
12. Maruo Y, Iwai M, Mori A, Sato H, Takeuchi Y. Polymorphism of UDP-glucuronosyltransferase and drug metabolism[J]. Curr Drug Metab, 2005, 6(2):91-99.
13. Bosma PJ, Chowdhury JR, Bakker C, Gantla S, de Boer A, Oostra BA, et al. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome[J]. N Engl J Med, 1995, 333(18):1171-1175.
14. Maruo Y, Nishizawa K, Sato H, Doida Y, Shimada M. Association of neonatal hyperbilirubinemia with bilirubin UDP-glucuronosyltransferase polymorphism [J]. Pediatrics, 1999, 103(6 Pt 1):1224-1227.
15. Ehmer U, Vogel A, Schütte JK, Krone B, Manns MP, Strassburg CP. Variation of hepatic glucuronidation: novel functional polymorphisms of the UDP-glucuronosyltransferase UGT1A4[J]. Hepatology, 2004, 39(4):970-977.
16. Iwai M, Maruo Y, Ito M, Yamamoto K, Sato H, Takeuchi Y. Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity [J]. J Hum Genet, 2004, 49(3):123-128.
17. Ciotti M, Marrone A, Potter C, Owens IS. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: pharmacological implications[J]. Pharmacogenetics, 1997, 7(6):485-495.
18. Guillemette C, Ritter JK, Auyeung DJ, Kessler FK, Housman DE. Structural heterogeneity at the UDP-glucuronosyltransferase 1 locus: functional consequences of three novel missense mutations in the human UGT1A7 gene[J]. Pharmacogenetics, 2000, 10(7):629-644.
19. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, et al. Identification and functional characterization of UDP- glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3[J]. Pharmacogenetics, 2002, 12(4):287-297.
20. Jinno H, Saeki M, Tanaka-Kagawa T, Hanioka N, Saito Y, Ozawa S, et al. Functional characterization of wild-type and variant (T202I and M59I) human UDP-glucuronosyltransferase 1A10[J]. Drug Metab Dispos, 2003, 31(5):528-532.
21. Lévesque E, Beaulieu M, Hum DW, Bélanger A. Characterization and substrate specificity of UGT2B4 (E458): a UDP-glucuronosyltransferase encoded by a polymorphic gene[J]. Pharmacogenetics, 1999, 9(2):207-216.
22. Jin C, Miners JO, Lillywhite KJ, Mackenzie PI. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs[J]. J Pharmacol Exp Ther, 1993, 264(1):475-479.
23. Lévesque E, Beaulieu M, Green MD, Tephly TR, Bélanger A, Hum DW. Isolation and characterization of UGT2B15 (Y85): a UDP- glucuronosyltransferase encoded by a polymorphic gene[J]. Pharmacogenetics, 1997, 7(4):317-325.
24. Ritter JK, Yeatman MT, Ferreira P, Owens IS. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient[J]. J Clin Invest, 1992, 90(1):150-155.
25. Bosma PJ, Seppen J, Goldhoorn B, Bakker C, Oude Elferink RP, Chowdhury JR, et al. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man[J]. J Biol Chem, 1994, 269(27):17960-17964.
26. Labrune P, Myara A, Chalas J, Le Bihan B, Capel L, Francoual J. Association of a homozygous (TA) 8 promoter polymorphism and a N400D mutation of UGT1A1 in a child with Crigler-Najjar type II syndrome[J]. Hum Mutat, 2002, 20(5):399-401.
27. Bhasker CR, McKinnon W, Stone A, Lo AC, Kubota T, Ishizaki T, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance[J]. Pharmacogenetics, 2000, 10(8):679-685.
28. Vogel A, Kneip S, Barut A, Ehmer U, Tukey RH, Manns MP, et al. Genetic link of hepatocellular carcinoma with polymorphisms of the UDP-glucuronosyltransferase UGT1A7 gene[J]. Gastroenterology, 2001, 121(5):1136-1144.
29. Miners JO, McKinnon RA, Mackenzie PI. Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance[J]. Toxicology, 2002, 181-182:453-456.
30. Carlini LE, Meropol NJ, Bever J, Andria ML, Hill T, Gold P, et al. UGT1A7 And UGT1A9 polymorphisms predict response and toxicity in colorectal cancer patients treated with capecitabine/irinotecan[J]. Clin Cancer Res, 2005, 11(3):1226-1236.
31. Chung JY, Cho JY, Yu KS, Kim JR, Jung HR, Lim KS, et al. Effect of the UGT2B15 genotype on the pharmacokinetics, pharmacodynamics, and drug interactions of intravenous lorazepam in healthy volunteers[J]. Clin Pharmacol Ther, 2005, 77(6):486-494.
32. Bhasker CR, McKinnon W, Stone A, Lo AC, Kubota T, Ishizaki T, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance[J]. Pharmacogenetics, 2000, 10(8):679-685.
33. Miners JO, Lillywhite KJ, Matthews AP, Jones ME, Birkett DJ. Kinetic and inhibitor studies of 4-methylum-belliferone and 1-naphthol glucuronidation in human liver microsomes[J]. Biochem Pharmacol, 1988, 37(4):665-671.
34. Bock KW, Burchell B, Dutton GJ, Hänninen O, Mulder GJ, Owens IS, et al. UDP-glucuronosyltransferase activities. Guidelines for consistent interim terminology and assay conditions[J]. Biochem Pharmacol, 1983, 32(6):953-955.