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1
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33645551786
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Community-acquired methicillin-resistant Staphylococcus aureus: current perspectives
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A recent review of the epidemiology of MRSA in different countries.
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Kluytmans-Vandenbergh M.F., and Kluytmans J.A. Community-acquired methicillin-resistant Staphylococcus aureus: current perspectives. Clin Microbiol Infect 12 Suppl 1 (2006) 9-15. A recent review of the epidemiology of MRSA in different countries.
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Clin Microbiol Infect
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Kluytmans-Vandenbergh, M.F.1
Kluytmans, J.A.2
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34047121205
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Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006
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Provides an overview of some of the molecular typing methods commonly used to characterize MRSA isolates.
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Tristan A., Bes M., Meugnier H., Lina G., Bozdogan B., Courvalin P., Reverdy M.E., Enright M.C., Vandenesch F., and Etienne J. Global distribution of Panton-Valentine leukocidin-positive methicillin-resistant Staphylococcus aureus, 2006. Emerg Infect Dis 13 (2007) 594-600. Provides an overview of some of the molecular typing methods commonly used to characterize MRSA isolates.
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Emerg Infect Dis
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Tristan, A.1
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3
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35848964544
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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals
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Describes the epidemiology and clinical features of hospitalized patients with high-level mupirocin MRSA in a network of Canadian hospitals between 1995 and 2004. The article describes how these isolates were characterized, their molecular epidemiology, and mechanism of mupirocin resistance.
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Simor A.E., Stuart T.L., Louie L., Watt C., Ofner-Agostini M., Gravel D., Mulvey M., Loeb M., McGeer A., Bryce E., and Matlow A. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus strains in Canadian hospitals. Antimicrob Agents Chemother 51 (2007) 3880-3886. Describes the epidemiology and clinical features of hospitalized patients with high-level mupirocin MRSA in a network of Canadian hospitals between 1995 and 2004. The article describes how these isolates were characterized, their molecular epidemiology, and mechanism of mupirocin resistance.
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Antimicrob Agents Chemother
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Simor, A.E.1
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Loeb, M.8
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Matlow, A.11
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4
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0141890225
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Isoleucyl-tRNA synthetase mutations in Staphylococcus aureus clinical isolates and in vitro selection of low-level mupirocin-resistant strains
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Fujimura S., Tokue Y., and Watanabe A. Isoleucyl-tRNA synthetase mutations in Staphylococcus aureus clinical isolates and in vitro selection of low-level mupirocin-resistant strains. Antimicrob Agents Chemother 47 (2003) 3373-3374
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Fujimura, S.1
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5
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0038440747
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A chromosomal location of the mupA gene in Staphylococcus aureus expressing high-level mupirocin resistance
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Udo E.E., Al-Sweih N., and Noronha B.C. A chromosomal location of the mupA gene in Staphylococcus aureus expressing high-level mupirocin resistance. J Antimicrob Chemother 51 (2003) 1283-1286
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Udo, E.E.1
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33846131258
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Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization
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Simor A.E., Phillips E., McGeer A., Konvalinka A., Loeb M., Devlin H.R., and Kiss A. Randomized controlled trial of chlorhexidine gluconate for washing, intranasal mupirocin, and rifampin and doxycycline versus no treatment for the eradication of methicillin-resistant Staphylococcus aureus colonization. Clin Infect Dis 44 (2007) 178-185
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Simor, A.E.1
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Kiss, A.7
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7
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0037846461
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Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?
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Walker E.S., Vasquez J.E., Dula R., Bullock H., and Sarubbi F.A. Mupirocin-resistant, methicillin-resistant Staphylococcus aureus: does mupirocin remain effective?. Infect Control Hosp Epidemiol 24 (2003) 342-346
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Walker, E.S.1
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8
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0034602449
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Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site
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Laurberg M., Kristensen O., Martemyanov K., Gudkov A.T., Nagaev I., Hughes D., and Liljas A. Structure of a mutant EF-G reveals domain III and possibly the fusidic acid binding site. J Mol Biol 303 (2000) 593-603
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9
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34248592109
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Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus
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O'Neill A.J., Larsen A.R., Skov R., Henriksen A.S., and Chopra I. Characterization of the epidemic European fusidic acid-resistant impetigo clone of Staphylococcus aureus. J Clin Microbiol 45 (2007) 1505-1510
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O'Neill, A.J.1
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10
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33645079390
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Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus
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O'Neill A.J., and Chopra I. Molecular basis of fusB-mediated resistance to fusidic acid in Staphylococcus aureus. Mol Microbiol 59 (2006) 664-676
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Mol Microbiol
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O'Neill, A.J.1
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12
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37649025262
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Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children
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A recent review of the key preclinical and clinical properties of retapamulin, a new topical antibiotics recently launched in the USA and Europe by GlaxoSmithKline.
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Jacobs M.R. Retapamulin: a semisynthetic pleuromutilin compound for topical treatment of skin infections in adults and children. Future Microbiol 2 (2007) 591-600. A recent review of the key preclinical and clinical properties of retapamulin, a new topical antibiotics recently launched in the USA and Europe by GlaxoSmithKline.
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Future Microbiol
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Jacobs, M.R.1
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14
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35948967529
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Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells
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Champney W.S., and Rodgers W.K. Retapamulin inhibition of translation and 50S ribosomal subunit formation in Staphylococcus aureus cells. Antimicrob Agents Chemother 51 (2007) 3385-3387
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Antimicrob Agents Chemother
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Champney, W.S.1
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15
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33750600405
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Yan K., Madden L., Choudhry A.E., Voigt C.S., Copeland R.A., and Gontarek R.R. Biochemical characterization of the interactions of the novel pleuromutilin derivative retapamulin with bacterial ribosomes. Antimicrob Agents Chemother 50 (2006) 3875-3881
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Yan, K.1
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17
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25844443589
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Antibacterial activity of REP8839, a new antibiotic for topical use
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This study describes the initial microbiological profile of REP8839 including its activity against key phenotypes of S. aureus.
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Critchley I.A., Young C.L., Stone K.C., Ochsner U.A., Guiles J., Tarasow T., and Janjic N. Antibacterial activity of REP8839, a new antibiotic for topical use. Antimicrob Agents Chemother 49 (2005) 4247-4252. This study describes the initial microbiological profile of REP8839 including its activity against key phenotypes of S. aureus.
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Critchley, I.A.1
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Guiles, J.5
Tarasow, T.6
Janjic, N.7
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18
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33846845032
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Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors
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Bharatham N., Bharatham K., and Lee K.W. Pharmacophore identification and virtual screening for methionyl-tRNA synthetase inhibitors. J Mol Graph Model 25 (2007) 813-823
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Bharatham, N.1
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33748748544
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Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors
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Farhanullah, Kim S.Y., Yoon E.J., Choi E.C., Kim S., Kang T., Samrin F., Puri S., and Lee J. Design and synthesis of quinolinones as methionyl-tRNA synthetase inhibitors. Bioorg Med Chem 14 (2006) 7154-7159
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Bioorg Med Chem
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Farhanullah1
Kim, S.Y.2
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Kim, S.5
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20
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Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents
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Hurdle J.G., O'Neill A.J., and Chopra I. Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents. Antimicrob Agents Chemother 49 (2005) 4821-4833
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Antimicrob Agents Chemother
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Hurdle, J.G.1
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Chopra, I.3
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21
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34248340854
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Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis
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Kedar G.C., Brown-Driver V., Reyes D.R., Hilgers M.T., Stidham M.A., Shaw K.J., Finn J., and Haselbeck R.J. Evaluation of the metS and murB loci for antibiotic discovery using targeted antisense RNA expression analysis in Bacillus anthracis. Antimicrob Agents Chemother 51 (2007) 1708-1718
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Antimicrob Agents Chemother
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Kedar, G.C.1
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Shaw, K.J.6
Finn, J.7
Haselbeck, R.J.8
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22
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34248339238
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Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents
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A comprehensive review of amino acyl tRNA synthetases, including MetRS, and their suitability as novel targets for antibiotic development.
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Ochsner U.A., Sun X., Jarvis T., Critchley I., and Janjic N. Aminoacyl-tRNA synthetases: essential and still promising targets for new anti-infective agents. Expert Opin Investig Drugs 16 (2007) 573-593. A comprehensive review of amino acyl tRNA synthetases, including MetRS, and their suitability as novel targets for antibiotic development.
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Expert Opin Investig Drugs
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Ochsner, U.A.1
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Janjic, N.5
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23
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1642619403
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Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold
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Tandon M., Coffen D.L., Gallant P., Keith D., and Ashwell M.A. Potent and selective inhibitors of bacterial methionyl tRNA synthetase derived from an oxazolone-dipeptide scaffold. Bioorg Med Chem Lett 14 (2004) 1909-1911
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Bioorg Med Chem Lett
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Tandon, M.1
Coffen, D.L.2
Gallant, P.3
Keith, D.4
Ashwell, M.A.5
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24
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33947258351
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Diagnosis and treatment of impetigo
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A recent review is describing the clinical properties of impetigo as a superficial skin infection and the use of topical and systemic agents to treat these infections.
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Cole C., and Gazewood J. Diagnosis and treatment of impetigo. Am Fam Phys 75 (2007) 859-864. A recent review is describing the clinical properties of impetigo as a superficial skin infection and the use of topical and systemic agents to treat these infections.
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Cole, C.1
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25
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Efficacy and safety of retapamulin ointment as treatment of impetigo: randomized double-blind multicentre placebo-controlled trial
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This study describes the results from a Phase III clinical trial to evaluate the safety and efficacy of topical retapamulin in treating impetigo.
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Koning S., van der Wouden J.C., Chosidow O., Twynholm M., Singh K.P., Scangarella N., and Oranje A.P. Efficacy and safety of retapamulin ointment as treatment of impetigo: randomized double-blind multicentre placebo-controlled trial. Br J Dermatol 158 (2008) 1077-1082. This study describes the results from a Phase III clinical trial to evaluate the safety and efficacy of topical retapamulin in treating impetigo.
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Br J Dermatol
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Koning, S.1
van der Wouden, J.C.2
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Scangarella, N.6
Oranje, A.P.7
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26
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Management of common bacterial infections of the skin
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A review describes common bacterial skin infections, pathogens, and current treatment strategies.
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Bernard P. Management of common bacterial infections of the skin. Curr Opin Infect Dis 21 (2008) 122-128. A review describes common bacterial skin infections, pathogens, and current treatment strategies.
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Curr Opin Infect Dis
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Bernard, P.1
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Emergence of USA300 MRSA in a tertiary medical centre: implications for epidemiological studies
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Patel M., Waites K.B., Hoesley C.J., Stamm A.M., Canupp K.C., and Moser S.A. Emergence of USA300 MRSA in a tertiary medical centre: implications for epidemiological studies. J Hosp Infect 68 (2008) 208-213
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Skiest D.J., and Cooper T.W. High recurrence rate of CA-MRSA skin and soft tissue infections. Arch Intern Med 167 (2007) 2527 author
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Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens
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Of significance because it was the first study describing inhibitors of S. aureus MetRS and their potential as novel antibacterial agents.
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Jarvest R.L., Berge J.M., Berry V., Boyd H.F., Brown M.J., Elder J.S., Forrest A.K., Fosberry A.P., Gentry D.R., Hibbs M.J., et al. Nanomolar inhibitors of Staphylococcus aureus methionyl tRNA synthetase with potent antibacterial activity against gram-positive pathogens. J Med Chem 45 (2002) 1959-1962. Of significance because it was the first study describing inhibitors of S. aureus MetRS and their potential as novel antibacterial agents.
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J Med Chem
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Jarvest, R.L.1
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Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity
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Jarvest R.L., Berge J.M., Brown M.J., Brown P., Elder J.S., Forrest A.K., Houge-Frydrych C.S., O'Hanlon P.J., McNair D.J., Rittenhouse S., and Sheppard R.J. Optimisation of aryl substitution leading to potent methionyl tRNA synthetase inhibitors with excellent gram-positive antibacterial activity. Bioorg Med Chem Lett 13 (2003) 665-668
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Bioorg Med Chem Lett
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Jarvest, R.L.1
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31
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Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity
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Jarvest R.L., Berge J.M., Brown P., Houge-Frydrych C.S., O'Hanlon P.J., McNair D.J., Pope A.J., and Rittenhouse S. Conformational restriction of methionyl tRNA synthetase inhibitors leading to analogues with potent inhibition and excellent gram-positive antibacterial activity. Bioorg Med Chem Lett 13 (2003) 1265-1268
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Jarvest R.L., Armstrong S.A., Berge J.M., Brown P., Elder J.S., Brown M.J., Copley R.C., Forrest A.K., Hamprecht D.W., O'Hanlon P.J., et al. Definition of the heterocyclic pharmacophore of bacterial methionyl tRNA synthetase inhibitors: potent antibacterially active non-quinolone analogues. Bioorg Med Chem Lett 14 (2004) 3937-3941
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Jarvest, R.L.1
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Brown, M.J.6
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33
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Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens
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Provides a phylogenetic analysis of MetRS among different bacteria.
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Brown J.R., Gentry D., Becker J.A., Ingraham K., Holmes D.J., and Stanhope M.J. Horizontal transfer of drug-resistant aminoacyl-transfer-RNA synthetases of anthrax and Gram-positive pathogens. EMBO Rep 4 (2003) 692-698. Provides a phylogenetic analysis of MetRS among different bacteria.
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EMBO Rep
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Brown, J.R.1
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Bernier S., Akochy P.M., Lapointe J., and Chenevert R. Synthesis and aminoacyl-tRNA synthetase inhibitory activity of aspartyl adenylate analogs. Bioorg Med Chem 13 (2005) 69-75
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Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity
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Shen N., Guo L., Yang B., Jin Y., and Ding J. Structure of human tryptophanyl-tRNA synthetase in complex with tRNATrp reveals the molecular basis of tRNA recognition and specificity. Nucleic Acids Res 34 (2006) 3246-3258
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Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes
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This is the first report to describe a divergent metRS2 enzyme in S. pneumoniae.
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Gentry D.R., Ingraham K.A., Stanhope M.J., Rittenhouse S., Jarvest R.L., O'Hanlon P.J., Brown J.R., and Holmes D.J. Variable sensitivity to bacterial methionyl-tRNA synthetase inhibitors reveals subpopulations of Streptococcus pneumoniae with two distinct methionyl-tRNA synthetase genes. Antimicrob Agents Chemother 47 (2003) 1784-1789. This is the first report to describe a divergent metRS2 enzyme in S. pneumoniae.
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Antimicrob Agents Chemother
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Gentry, D.R.1
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Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase
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This is the first report describing the biochemical and microbiological mode of action of REP8839 confirming metRS as the target.
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Ochsner U.A., Young C.L., Stone K.C., Dean F.B., Janjic N., and Critchley I.A. Mode of action and biochemical characterization of REP8839, a novel inhibitor of methionyl-tRNA synthetase. Antimicrob Agents Chemother 49 (2005) 4253-4262. This is the first report describing the biochemical and microbiological mode of action of REP8839 confirming metRS as the target.
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Ochsner, U.A.1
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Drago L., De V.E., Nicola L., and Gismondo M.R. In vitro evaluation of antibiotics' combinations for empirical therapy of suspected methicillin resistant Staphylococcus aureus severe respiratory infections. BMC Infect Dis 7 (2007) 111
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