Novel synthesis and pharmacological evaluation as α2-adrenoceptor ligands of O-phenylisouronium salts

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 17, 2008, Pages 8210-8217

  Goonan, Áine ^a   Kahvedžić, Amila ^a   Rodriguez, Fernando ^a   Nagle, Padraic S ^a   McCabe, Thomas ^a   Rozas, Isabel ^a   Erdozain, Amaia M ^b,c   Javier Meana, J ^b,c   Callado, Luis F ^b,c  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^c CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED DE SALUD MENTAL CIBERSAM   (Spain)

Author keywords

2 Adrenoceptors; Boc protected isoureas; Carbodiimide; Human brain tissue; O Isouronium salts

Indexed keywords

1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 2 (1 METHYL 2 ISOINDOLINYLMETHYL) 2 IMIDAZOLINE; 2 (2 METHOXY 1,4 BENZODIOXAN 2 YL) 2 IMIDAZOLINE; ALKANOL; ALPHA 2 ADRENERGIC RECEPTOR; ANTIDEPRESSANT AGENT; CLONIDINE; CYANAMIDE; IDAZOXAN; LIGAND; MIRTAZAPINE; O PHENYLISOURONIUM SALT; PHENOL; UNCLASSIFIED DRUG; UREA DERIVATIVE; URIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; BRAIN TISSUE; CHEMICAL REACTION; DRUG ACTIVITY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; IN VITRO STUDY;

ANTIDEPRESSIVE AGENTS; BRAIN; CRYSTALLOGRAPHY, X-RAY; DRUG EVALUATION, PRECLINICAL; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, ADRENERGIC, ALPHA-2; SALTS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFIDES; UREA;

EID: 50449092676     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.07.033     Document Type: Article

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