Transformation of a κ-opioid receptor antagonist to a κ-agonist by transfer of a guanidinium group from the 5′- to 6′-position of naltrindole

Journal of Medicinal Chemistry

Volumn 44, Issue 13, 2001, Pages 2073-2079

  Kumar Sharma, S ^a   Jones, R M ^a   Metzger, T G ^a   Ferguson, D M ^a   Portoghese, P S ^a  

^a UNIVERSITY OF MINNESOTA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMINE; GUANIDINE; KAPPA OPIATE RECEPTOR AGONIST; KAPPA OPIATE RECEPTOR ANTAGONIST; NALTRINDOLE;

ANIMAL TISSUE; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSFORMATION; HUMAN; HUMAN CELL; ISOMER; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY;

ANIMALS; CELL LINE; CLONING, MOLECULAR; GUANIDINE; GUINEA PIGS; HUMANS; MOLECULAR CONFORMATION; MUSCLE CONTRACTION; MUSCLE, SMOOTH; MUTAGENESIS, SITE-DIRECTED; NALTREXONE; NARCOTIC ANTAGONISTS; RATS; RECEPTORS, OPIOID, KAPPA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 0035927440     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010095v     Document Type: Article

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