Using dietary exposure and physiologically based pharmacokinetic/ pharmacodynamic modeling in human risk extrapolations for acrylamide toxicity

Journal of Agricultural and Food Chemistry

Volumn 56, Issue 15, 2008, Pages 6031-6038

  Doerge, Daniel R ^a,c   Young, John F ^a   Chen, James J ^a   DiNovi, Michael J ^b   Henry, Sara H ^b  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

^b CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^c NCTR   (United States)

Author keywords

Acrylamide; Cancer; DNA adducts; Glycidamide; Neurotoxicity; PBPK modeling; Risk assessment

Indexed keywords

ACRYLAMIDE; CARCINOGEN;

ANIMAL; BIOLOGICAL MODEL; CHEMICALLY INDUCED DISORDER; CHEMISTRY; CONFERENCE PAPER; DIET; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; HEAT; HUMAN; NEOPLASM; RISK ASSESSMENT;

ACRYLAMIDE; ANIMALS; CARCINOGENS; DIET; ENVIRONMENTAL EXPOSURE; FOOD CONTAMINATION; HEAT; HUMANS; MODELS, BIOLOGICAL; NEOPLASMS; RISK ASSESSMENT;

RODENTIA;

EID: 50449086312     PISSN: 00218561     EISSN: None     Source Type: Journal    
DOI: 10.1021/jf073042g     Document Type: Conference Paper

References (61)

1. LoPachin, R. M.; Balaban, C. D.; Ross, J. F. Acrylamide axonopathy revisited. Toxicol. Appl. Pharmacol. 2003, 188, 135-153.
2. Hagmar, L.; Törnqvist, M.; Nordander, C.; Rosen, I.; Bruze, M.; Kautiainen, A.; Magnusson, A. L.; Malmberg, B.; Aprea, P.; Granath, F.; Axmon, A. Health effects of occupational exposure to acrylamide using hemoglobin adducts as biomarkers of internal dose. Scand. J. Work. Environ. Health 2001, 27, 219-226.
3. Bull, R.; Robinson, M.; Laurie, R.; Stoner, G. D.; Greisinger, E.; Meier, J. R.; Stober, J. Carcinogenic effects of acrylamide in Sencar and A/J mice. Cancer Res. 1984, 44, 107-111.
4. Bull, R.; Robinson, M.; Stober, J. Carcinogenic activity of acrylamide in the skin and lung of Swiss-ICR mice. Cancer Lett. 1984, 24, 209-212.
5. Johnson, K. A.; Gorzinski, S. J.; Bodner, K. M.; Campbell, R. A.; Wolf, C. H.; Friedman, M. A.; Mast, R. Chronic toxicity and oncogenicity study on acrylamide incorporated in the drinking water of Fischer 344 rats. Toxicol. Appl. Pharmacol. 1986, 85, 154-168.
6. Friedman, M. A.; Dulak, L. H.; Stedman, M. A. A lifetime oncogenicity study in rats with acrylamide. Fundam. Appl. Toxicol. 1995, 27, 95-105.
7. Rosen, J.; Hellenas, K. E. Analysis of acrylamide in cooked foods by liquid chromatography tandem mass spectrometry. Analyst 2002, 127, 880-882.
8. Tareke, E.; Rydberg, P.; Karlsson, P.; Eriksson, S.; Törnqvist, M. Analysis of acrylamide, a carcinogen formed in heated foodstuffs. J. Agric. Food Chem. 2002, 50, 4998-5006.
9. International Agency for Research on Cancer. Acrylamide. In Some Industrial Chemicals; IARC Monograph on the Evaluation of Carcinogenic Risks to Humans 60; IARC Press: Lyon, France, 1994; pp 1-45.
10. U.S. National Toxicology Program. 10th Report on Carcinogens; U.S. Department of Health and Human Services, online version available at http://ntp.niehs.nih.gov/ntp, 2002.
11. U.S. Environmental Protection Agency. Integrated Risk Information System (IRIS); Acrylamide; available at http://www.epa.gov/iris/subst/0286.htm, 1993.
12. JECFA. Acrylamide in Safety Evaluation of Certain Contaminants in Food. Prepared by the 64th meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA); FAO Food and Nutrition Paper 82, pp 1-778; available online at http://whqlibdoc.who.int/publications/2006/9241660554_ACR_eng.pdf, 2006.
13. Ruden, C. Acrylamide and cancer risk - expert risk assessments and the public debate. Food Chem. Toxicol. 2004, 42, 335-349.
14. Konings, E. J.; Baars, A. J.; van Klaveren, J. D.; Spanjer, M. C.; Rensen, P. M.; Hiemstra, M.; van Kooij, J. A.; Peters, P. W. Acrylamide exposure from foods of the Dutch population and an assessment of the consequent risks. Food Chem. Toxicol. 2003, 41, 1569-1579.
15. U.S. Food and Drug Administration. Report of the Quantitative Risk Assessment Committee, Assessment of carcinogenic upper-bound lifetime risk resulting from contamination by acrylamide of copolymers, retention aids, drainage aids, stabilizer or fixing agents in paper and paperboard contacting foods, 1998.
16. Gaylor, D. W.; Axelroad, J. A.; Brown, R. P.; Cavagnaro, J. A.; Cyr, W. H.; Hulebak, K. L.; Lorentzen, R. J.; Miller, M. A.; Mulligan, L. T.; Schwetz, B. A. Health risk assessment practices in the U.S. Food and Drug Administration. Reg. Toxicol. Pharmacol. 1997, 26, 301-321.
17. Dybing, E.; Sanner, T. Risk assessment of acrylamide in foods. Toxicol. Sci. 2003, 75, 7-15.
18. Mucci, L. A.; Adami, H.-O. The role of epidemiology in understanding the relationship between dietary acrylamide and cancer risk in humans. Adv. Exp. Med. Biol. 2005, 561, 39-47.
19. Hagmar, L.; Törnqvist, M. Inconclusive results from an epidemiological study on dietary acrylamide and cancer. Br. J. Cancer 2003, 89, 774-775.
20. Vainio, H. Acrylamide in heat-processed foods - a carcinogen looking for human cancer. Eur. J. Epidemiol. 2003, 18, 1105-1106.
21. Wirfält, E.; Paulsson, B.; Törnqvist, M.; Axmon, A.; Hagmar, L. Associations between estimated acrylamide intakes, and hemoglobin AA adducts in a sample from the Malmö Diet and Cancer cohort. Eur. J. Clin. Nutr. 2007, in press.
22. Bjellaas, T.; Oleson, P. T.; Frandsen, H.; Haugen, M.; Stolen, L. H.; Paulsen, J. E.; Alexander, J.; Lundanes, E.; Becher, G. Comparison of estimated dietary intake of acrylamide with hemoglobin adducts of acrylamide and glycidamide. Toxicol. Sci. 2007, 98, 110-117.
23. Kütting, B.; Uter, W.; Drexler, H. The association between self-reported acrylamide exposure intake and hemoglobin adducts as biomarkers of exposure. Cancer Causes Control 2007, in press.
24. International Agency for Research on Cancer. Ethylene oxide. In Some Industrial Chemicals; IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 60; IARC Press: Lyon, France, 1994; pp 45-71.
25. Irwin, R. D.; Eustis, S. L.; Stefanski, S.; Haseman, J. K. Carcinogenicity of glycidol in F344 rats and B6C3F1 mice. J. Appl. Toxicol. 1996, 16, 201-209.
26. Solomon, J. J.; Fedyk, J.; Mukai, F.; Segal, A. Direct alkylation of 2′-deoxynucleosides and DNA following in vitro reaction with acrylamide. Cancer Res. 1985, 45, 3465-3470.
27. 14C]acrylamide. Carcinogenesis 1995, 16, 1161-1165.
28. Gamboa da Costa, G.; Churchwell, M. I.; Hamilton, L. P.; Beland, F. A.; Marques, M. M.; Doerge, D. R. DNA adduct formation from acrylamide via conversion to glycidamide in adult and neonatal mice. Chem. Res. Toxicol. 2003, 16, 1328-1337.
29. Doerge, D. R.; Gamboa da Costa, G.; McDaniel, L. P.; Churchwell, M. I.; Twaddle, N. C.; Beland, F. A. DNA adducts derived from administration of acrylamide and glycidamide to mice and rats. Mutat. Res. 2005, 580, 131-142.
30. Hashimoto, K.; Tanii, H. Mutagenicity of acrylamide and its analogues in Salmonella typhimurium. Mutat. Res. 1985, 158, 129-133.
31. Besaratinia, A.; Pfeifer, G. P. Genotoxicity of acrylamide and glycidamide. J. Nat. Cancer Inst. 2004, 96, 1023-1029.
32. Paulsson, B.; Kotova, N.; Grawe, J.; Henderson, A.; Granath, F.; Golding, B.; Törnqvist, M. Induction of micronuclei in mouse and rat by glycidamide, genotoxic metabolite of acrylamide. Mutat. Res. 2003, 535, 15-24.
33. Ghanayem, B. I.; Hamilton, L. P.; Churchwell, M. I.; Twaddle, N. C.; Snyder, R.; Fennell, T. R.; Doerge, D. R. Role of CYP2E1 in the epoxidation of acrylamide to glycidamide and formation of DNA and hemoglobin adducts. Toxicol. Sci. 2005, 88, 311-318.
34. Ghanayem, B. I.; Witt, K. L.; Kissling, G. E.; Tice, R. R.; Recio, L. Absence of acrylamide-induced genotoxicity in CYP2E1-null mice: evidence consistent with a glycidamide-mediated effect. Mutat. Res. 2005, 578, 284-297.
35. Ghanayem, B. I.; Witt, K. L.; El-Hadri, L.; Hoffler, U.; Kissling, G. E.; Shelby, M. D.; Bishop, J. B. Comparison of germ cell mutagenicity in male CYP2E1-null and wild-type mice treated with acrylamide: evidence supporting a glycidamide-mediated effect. Biol. Reprod. 2005, 72, 157-163.
36. Manjanatha, M. G.; Aidoo, A.; Shelton, S. D.; Bishop, M. E.; McDaniel, L. P.; Lyn-Cook, L. E.; Doerge, D. R. Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice. Environ. Mol. Mutagen. 2006, 47, 6-17.
37. Paulsson, B.; Grawe, J.; Törnqvist, M. Hemoglobin adducts and micronucleus frequencies in mouse and rat after acrylamide or N-methylolacrylamide treatment. Mutat. Res. 2002, 516, 101-111.
38. Fennell, T. R.; Snyder, R. W.; Krol, W. L.; Sumner, S. C. Comparison of the hemoglobin adducts formed by administration of N-methylolacrylamide and acrylamide to rats. Toxicol. Sci. 2003, 71, 164-175.
39. Bucher, J. R.; Huff, J.; Haseman, J. K.; Eustis, S. L.; Peters, A.; Toft, J. D. Neurotoxicity and carcinogenicity of N-methylolacrylamide in F344 rats and B6C3F1 mice. J. Toxicol. Environ. Health 1990, 31, 161-177.
40. Shipp, A.; Lawrence, G.; Gentry, R.; McDonald, T.; Bartow, H.; Bounds, J.; MacDonald, M.; Clewell, H.; Allen, B.; Van Landingham, C. Acrylamide: review of toxicity data and dose-response analyses for cancer and noncancer effects. Crit. Rev. Toxicol. 2006, 36, 481-608.
41. Park, J.; Kamendulis, L. M.; Friedman, M. A.; Klaunig, J. E. Acrylamide-induced cellular transformation. Toxicol. Sci. 2002, 65, 177-183.
42. Sickles, D. W.; Sperry, A. O.; Testino, A.; Friedman, M. Acrylamide effects on kinesin-related proteins of the mitotic/meiotic spindle. Toxicol. Appl. Pharmacol. 2007, 222, 111-121.
43. Poirier, M. C.; Beland, F. A. DNA adduct measurements and tumor incidence during chronic carcinogen exposure in animal models: implications for DNA adduct-based human cancer risk assessment. Chem. Res. Toxicol. 1992, 5, 749-755.
44. Young, J. F.; Luecke, R. H.; Doerge, D. R. Physiologically based pharmacokinetic/pharmacodynamic model for acrylamide and its metabolites in mice, rats and humans. Chem. Res. Toxicol. 2007, 20, 388-399.
45. 1 mice. Toxicol. Appl. Pharmacol. 2005, 202, 258-267.
46. Doerge, D. R.; Young, J. F.; McDaniel, L. P.; Twaddle, N. C.; Churchwell, M. I. Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats. Toxicol. Appl. Pharmacol. 2005, 208, 199-209.
47. Tareke, E.; McDaniel, L. P.; Churchwell, M. I.; Twaddle, N. C.; Doerge, D. R. Relationship between biomarkers of exposure and toxicokinetics in Fischer 344 rats and B6C3F1 mice administered single doses of acrylamide and glycidamide and multiple doses of acrylamide. Toxicol. Appl. Pharmacol. 2006, 217, 63-75.
48. 1 mice administered a single dose of acrylamide. Toxicol. Lett. 2007, 169, 34-42.
49. Boettcher, M. I.; Schettgen, T.; Kutting, B.; Pischetsrieder, M.; Angerer, J. Mercapturic acids of acrylamide and glycidamide as biomarkers of the internal exposure to acrylamide in the general population. Mutat. Res. 2005, 580, 167-176.
50. Boon, P. E.; de Mul, A.; van der Voet, H.; van Donkersgoed, G.; Brette, M.; van Klavern, J. Calculations of dietary exposure to acrylamide. Mutat. Res. 2005, 580, 143-155.
51. Burek, J. D.; Albee, R. R.; Beyer, J. E.; Bell, T. J.; Carreon, R. M.; Morden, D. C.; Wade, C. E.; Hermann, E. A.; Gorzinski, S. J. Subchronic toxicity of acrylamide administered to rats in the drinking water followed by up to 144 days of recovery. J. Environ. Pathol. Toxicol. 1980, 4, 157-182.
52. Doll, R.; Peto, R. The causes of cancer quantitative estimates of avoidable risks of cancer in the United States today. J. Natl. Cancer Inst. 1981, 66, 1191-1308.
53. Somoza, V.; Wenzel, E.; Lindenmeier, M.; Grothe, D.; Erbersdobler, H. F.; Hofmann, T. Influence of feeding malt, bread crust, and a pronylated protein on the activity of chemopreventive enzymes and antioxidative defense parameters in vivo. J. Agric. Food Chem. 2005, 53, 8176-8182.
54. Paulsson, B.; Athanassiadis, I.; Rydgerg, P.; Törnqvist, M. Hemoglobin adducts from glycidamide: acetonization of hydrophilic groups for reproducible gas chromatography/tandem mass spectrometric analysis. Rapid Commun. Mass Spectrom. 2003, 17, 1859-1865.
55. Bjellaas, T.; Janak, K.; Lundanes, E.; Kronberg, L.; Becher, G. Determination and quantification of urinary metabolites after dietary exposure to acrylamide. Xenobiotica 2005, 35, 1003-1018.
56. Urban, M.; Kavvadias, D.; Reidel, K.; Scherer, G.; Tricker, A. R. Urinary mercapturic acids and a hemoglobin adduct for the dosimetry of acrylamide exposure in smokers and nonsmokers. Inhal. Toxicol. 2006, 18, 831-839.
57. Vesper, H. W.; Licea-Perez, H.; Meyers, T.; Ospina, M.; Meyers, G. L. Pilot study on the impact of potato chips consumption on biomarkers of acrylamide exposure. Adv. Exp. Med. Biol. 2005, 561, 89-96.
58. Fennell, T. R.; Sumner, S. C. J.; Snyder, R. W.; Burgess, J.; Spicer, R.; Bridson, W. E.; Friedman, M. A. Metabolism and hemoglobin adduct formation of acrylamide in humans. Toxicol. Sci. 2005, 85, 447-459.
59. Kellert, M.; Scholz, K.; Wagner, S.; Dekant, W.; Völkel, W. Quantitation of mercapturic acids from acrylamide and glycidamide in human urine using a column switching tool with two trap columns and electrospray tandem mass spectrometry. J. Chromatogr., A 2006, 1131, 58.
60. Chevolleau, S.; Jacques, C.; Canlet, C.; Tulliez, J.; Debrauwer, L. Analysis of hemoglobin adducts of acrylamide and glycidamide by liquid chromatography-electrospray tandem mass spectrometry, as exposure biomarkers in French population. J. Chromatogr., A 2007, 1167, 125-134.
61. Vesper, H. W.; Bernert, J. T.; Ospina, M.; Meyers, T.; Ingram, L.; Smith, A.; Meyers, G. L. Assessment of the relation between biomarkers for smoking and biomarkers for acrylamide exposure in humans. Cancer Epidemiol. Biomarkers Prev. 2007, 16, 2471-2478.