Encephalitozoon cuniculi mRNA Cap (guanine N-7) methyltransferase: Methyl acceptor specificity, inhibition by S-adenosylmethionine analogs, and structure-guided mutational analysis

Journal of Biological Chemistry

Volumn 280, Issue 21, 2005, Pages 20404-20412

  Hausmann, Stéphane ^a   Zheng, Sushuang ^a   Fabrega, Carme ^a   Schneller, Stewart W ^b   Lima, Christopher D ^a   Shuman, Stewart ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b AUBURN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; BIOCHEMISTRY; CATALYSIS; ENZYMES; MICROORGANISMS; SUBSTITUTION REACTIONS;

ALANINE; ENCEPHALITOZOON CUNICULI; METHYLTRANSFERASE; MRNA;

RNA;

ADENOSINE TRIPHOSPHATE; ALANINE; ASPARTIC ACID; CAPPED RNA; CYTIDINE TRIPHOSPHATE; DINUCLEOTIDE; FUNCTIONAL GROUP; GUANINE; GUANOSINE TRIPHOSPHATE; LYSINE; MESSENGER RNA; METHYL GROUP; MONOMER; PHENYLALANINE; PROTEIN ECM1; RNA METHYLTRANSFERASE; S ADENOSYLMETHIONINE; SINEFUNGIN; UNCLASSIFIED DRUG; URIDINE TRIPHOSPHATE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENCEPHALITOZOON CUNICULI; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; IC 50; IN VIVO STUDY; METHYLATION; MUTATION; NONHUMAN; PH; PRIORITY JOURNAL;

ADENOSINE; ANIMALS; BINDING SITES; CRYSTALLIZATION; ENCEPHALITOZOON CUNICULI; ENZYME INHIBITORS; GUANOSINE TRIPHOSPHATE; HYDROGEN-ION CONCENTRATION; METHYLATION; METHYLTRANSFERASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS; MUTATION, MISSENSE; RECOMBINANT PROTEINS; S-ADENOSYLHOMOCYSTEINE; S-ADENOSYLMETHIONINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

ENCEPHALITOZOON CUNICULI;

EID: 20144383545     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M501073200     Document Type: Article

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