A human monoclonal antiprothrombin antibody is thrombogenic in vivo and upregulates expression of tissue factor and E-selectin on endothelial cells

British Journal of Haematology

Volumn 135, Issue 2, 2006, Pages 214-219

  Vega Ostertag, Mariano ^b   Liu, Xiaowei ^b   Kwan Ki, Hwang ^c   Chen, Pojen ^c   Pierangeli, Silvia ^a,b  

^a University of Texas Medical Branch School of Medicine   (United States)

^b MOREHOUSE SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Anti prothrombin antibodies; Antiphospholipid antibodies; Antiphospholipid syndrome; Thrombosis

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; MESSENGER RNA; MONOCLONAL ANTIBODY; PROTHROMBIN ANTIBODY; THROMBOPLASTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL MODEL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; THROMBOGENESIS; THROMBOSIS;

ADOLESCENT; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIPHOSPHOLIPID SYNDROME; CELLS, CULTURED; E-SELECTIN; ENDOTHELIUM, VASCULAR; FEMALE; HUMANS; MALE; MICE; MICE, INBRED STRAINS; PROTHROMBIN; RNA, MESSENGER; THROMBOPLASTIN; THROMBOSIS; UMBILICAL VEINS; UP-REGULATION;

EID: 33748748970     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2006.06283.x     Document Type: Article

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