Site-Directed Mutagenesis of Recombinant Human β2-Glycoprotein I Identifies a Cluster of Lysine Residues That Are Critical for Phospholipid Binding and Anti-Cardiolipin Antibody Activity

Journal of Immunology

Volumn 157, Issue 8, 1996, Pages 3744-3751

  Sheng, Yonghua ^a   Sali, Andrej ^b   Herzog, Herbert ^c   Lahnstein, Jelle ^d   Krilis, Steven A ^a,e  

^a UNIVERSITY OF NEW SOUTH WALES   (Australia)

^b ROCKEFELLER UNIVERSITY   (United States)

^c ST VINCENT S HOSPITAL   (Australia)

^d Biotechnology Australia   (Australia)

^e ST GEORGE HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; CARDIOLIPIN ANTIBODY; GLYCOPROTEIN; LYSINE; PHOSPHOLIPID; PRIMER DNA; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARMYWORM; ARTICLE; BACULOVIRUS; BINDING SITE; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; ELECTRICITY; GENETICS; HUMAN; IMMUNOLOGY; IN VITRO STUDY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, ANTICARDIOLIPIN; BACULOVIRIDAE; BASE SEQUENCE; BETA 2-GLYCOPROTEIN I; BINDING SITES; CELL LINE; DNA PRIMERS; ELECTROSTATICS; GLYCOPROTEINS; HUMANS; LYSINE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOLIPIDS; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; RECOMBINANT PROTEINS; SPODOPTERA;

EID: 0030587953     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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