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Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H et al: Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 114(4):529-541. • This study demonstrated the role of myeloperoxidase-catalyzed oxidation of apoA-I in the generation of dysfunctional HDL. Inhibition of this pathway may improve the functional quality of HDL, without raising systemic HDL-C levels.
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Zheng L, Nukuna B, Brennan ML, Sun M, Goormastic M, Settle M, Schmitt D, Fu X, Thomson L, Fox PL, Ischiropoulos H et al: Apolipoprotein A-I is a selective target for myeloperoxidase-catalyzed oxidation and functional impairment in subjects with cardiovascular disease. J Clin Invest (2004) 114(4):529-541. • This study demonstrated the role of myeloperoxidase-catalyzed oxidation of apoA-I in the generation of dysfunctional HDL. Inhibition of this pathway may improve the functional quality of HDL, without raising systemic HDL-C levels.
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78
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34948834705
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Protein carbamylation links inflammation, smoking, uremia and atherogenesis
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This study demonstrated the role of carbamylation as a chemical pathway involved in the generation of dysfunctional HDL, •
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Wang Z, Nicholls SJ, Rodriguez ER, Kummu O, Hörkkö S, Barnard J, Reynolds WF, Topol EJ, DiDonato JA, Hazen SL: Protein carbamylation links inflammation, smoking, uremia and atherogenesis. Nat Med (2007) 13(10):1176-1184. • This study demonstrated the role of carbamylation as a chemical pathway involved in the generation of dysfunctional HDL.
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(2007)
Nat Med
, vol.13
, Issue.10
, pp. 1176-1184
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Wang, Z.1
Nicholls, S.J.2
Rodriguez, E.R.3
Kummu, O.4
Hörkkö, S.5
Barnard, J.6
Reynolds, W.F.7
Topol, E.J.8
DiDonato, J.A.9
Hazen, S.L.10
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79
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40949127806
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Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML et al: Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. J Am Med Assoc (2008) 299(11):1265-1276. •• This study defined the relationship between paraoxonase activity, measures of oxidative stress and cardiovascular risk, and suggested that promoting paraoxonase activity might improve the functional quality of HDL.
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Bhattacharyya T, Nicholls SJ, Topol EJ, Zhang R, Yang X, Schmitt D, Fu X, Shao M, Brennan DM, Ellis SG, Brennan ML et al: Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. J Am Med Assoc (2008) 299(11):1265-1276. •• This study defined the relationship between paraoxonase activity, measures of oxidative stress and cardiovascular risk, and suggested that promoting paraoxonase activity might improve the functional quality of HDL.
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80
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44449103671
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Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches
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An elegant description of the need to focus on the functional quality of HDL, ••
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deGoma EM, deGoma RL, Rader DJ: Beyond high-density lipoprotein cholesterol levels evaluating high-density lipoprotein function as influenced by novel therapeutic approaches. J Am Coll Cardiol (2008) 51(23):2199-2211. •• An elegant description of the need to focus on the functional quality of HDL.
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(2008)
J Am Coll Cardiol
, vol.51
, Issue.23
, pp. 2199-2211
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deGoma, E.M.1
deGoma, R.L.2
Rader, D.J.3
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