Association of chromosome 9p21 SNPs with cardiovascular phenotypes in morbid obesity using electronic health record data

Genomic Medicine

Volumn 2, Issue 1-2, 2008, Pages 33-43

  Wood, G Craig ^a   Still, Christopher D ^a   Chu, Xin ^a   Susek, Meghan ^a   Erdman, Robert ^a   Hartman, Christina ^a   Yeager, Stephanie ^a   Blosky, Mary Ann ^a   Krum, Wanda ^a   Carey, David J ^a   Skelding, Kimberly A ^a   Benotti, Peter ^a   Stewart, Walter F ^a   Gerhard, Glenn S ^a  

^a WEIS CENTER FOR RESEARCH   (United States)

Author keywords

Cardiovascular disease; Electronic health record; Morbid obesity; SNP; Type 2 diabetes

Indexed keywords

EID: 50249161481     PISSN: 18717934     EISSN: 18717942     Source Type: Journal    
DOI: 10.1007/s11568-008-9023-z     Document Type: Article

References (22)

1. LA Cupples HT Arruda EJ Benjamin RB D'Agostino Sr S Demissie AL DeStefano J Dupuis KM Falls CS Fox DJ Gottlieb DR Govindaraju CY Guo NL Heard-Costa SJ Hwang S Kathiresan DP Kiel JM Laramie MG Larson D Levy CY Liu KL Lunetta MD Mailman AK Manning JB Meigs JM Murabito C Newton-Cheh GT O'Connor CJ O'Donnell M Pandey S Seshadri RS Vasan ZY Wang JB Wilk PA Wolf Q Yang LD Atwood 2007 The Framingham Heart Study 100 K SNP genome-wide association study resource: overview of 17 phenotype working group reports BMC Med Genet 8 Suppl 1 S1
2. S de Lusignan 2006 The optimum granularity for coding diagnostic data in primary care: report of a workshop of the EFMI Primary Care Informatics Working Group at MIE 2005 Inform Prim Care 14 133 137
3. MA Eberle PC Ng K Kuhn L Zhou DA Peiffer L Galver KA Viaud-Martinez CT Lawley KL Gunderson R Shen SS Murray 2007 Power to detect risk alleles using genome-wide tag SNP panels PLoS Genet 3 1827 1837
4. K Flegal M Carroll C Ogden C Johnson 2002 Prevalence and trends in obesity among US adults JAMA 288 1723 1727
5. Gerhard G, Langer R, Carey D, Stewart W (in press) Electronic medical records in genomic medicine practice and research. In: Willard H, Ginsburg G (eds) Handbook of genomic medicine. Elsevier
6. A Helgadottir G Thorleifsson A Manolescu S Gretarsdottir T Blondal A Jonasdottir A Jonasdottir A Sigurdsson A Baker A Palsson G Masson DF Gudbjartsson KP Magnusson K Andersen AI Levey VM Backman S Matthiasdottir T Jonsdottir S Palsson H Einarsdottir S Gunnarsdottir A Gylfason V Vaccarino WC Hooper MP Reilly CB Granger H Austin DJ Rader SH Shah AA Quyyumi JR Gulcher G Thorgeirsson U Thorsteinsdottir A Kong K Stefansson 2007 A common variant on chromosome 9p21 affects the risk of myocardial infarction Science 316 1491 1493
7. DJ Koumanis NV Christou XL Wang BM Gilfix 2002 Pilot study examining the frequency of several gene polymorphisms in a morbidly obese population Obes Surg 12 759 764
8. MG Larson LD Atwood EJ Benjamin LA Cupples RB D'Agostino Sr CS Fox DR Govindaraju CY Guo NL Heard-Costa SJ Hwang JM Murabito C Newton-Cheh CJ O'Donnell S Seshadri RS Vasan TJ Wang PA Wolf D Levy 2007 Framingham Heart Study 100 K project: genome-wide associations for cardiovascular disease outcomes BMC Med Genet 8 Suppl 1 S5
9. R McPherson A Pertsemlidis N Kavaslar A Stewart R Roberts DR Cox DA Hinds LA Pennacchio A Tybjaerg-Hansen AR Folsom E Boerwinkle HH Hobbs JC Cohen 2007 A common allele on chromosome 9 associated with coronary heart disease Science 316 1488 1491
10. RJ Norman D Dewailly RS Legro TE Hickey 2007 Polycystic ovary syndrome Lancet 370 685 697
11. CJ O'Donnell LA Cupples RB D'Agostino CS Fox U Hoffmann SJ Hwang E Ingellson C Liu JM Murabito JF Polak PA Wolf S Demissie 2007 Genome-wide association study for subclinical atherosclerosis in major arterial territories in the NHLBI's Framingham Heart Study BMC Med Genet 8 Suppl 1 S4
12. SD Persell JM Wright JA Thompson KS Kmetik DW Baker 2006 Assessing the validity of national quality measures for coronary artery disease using an electronic health record Arch Intern Med 166 2272 2277
13. J Powell I Buchan 2005 Electronic health records should support clinical research J Med Internet Res 7 e4
14. NJ Samani J Erdmann AS Hall C Hengstenberg M Mangino B Mayer RJ Dixon T Meitinger P Braund HE Wichmann JH Barrett IR Konig SE Stevens S Szymczak DA Tregouet MM Iles F Pahlke H Pollard W Lieb F Cambien M Fischer W Ouwehand S Blankenberg AJ Balmforth A Baessler SG Ball TM Strom I Braenne C Gieger P Deloukas MD Tobin A Ziegler JR Thompson H Schunkert 2007 Genomewide association analysis of coronary artery disease N Engl J Med 357 443 453
15. R Saxena BF Voight V Lyssenko NP Burtt PI de Bakker H Chen JJ Roix S Kathiresan JN Hirschhorn MJ Daly TE Hughes L Groop D Altshuler P Almgren JC Florez J Meyer K Ardlie K Bengtsson Bostrom B Isomaa G Lettre U Lindblad HN Lyon O Melander C Newton-Cheh P Nilsson M Orho-Melander L Rastam EK Speliotes MR Taskinen T Tuomi C Guiducci A Berglund J Carlson L Gianniny R Hackett L Hall J Holmkvist E Laurila M Sjogren M Sterner A Surti M Svensson M Svensson R Tewhey B Blumenstiel M Parkin M Defelice R Barry W Brodeur J Camarata N Chia M Fava J Gibbons B Handsaker C Healy K Nguyen C Gates C Sougnez D Gage M Nizzari SB Gabriel GW Chirn Q Ma H Parikh D Richardson D Ricke S Purcell 2007 Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels Science 316 1331 1336
16. LJ Scott KL Mohlke LL Bonnycastle CJ Willer Y Li WL Duren MR Erdos HM Stringham PS Chines AU Jackson L Prokunina-Olsson CJ Ding AJ Swift N Narisu T Hu R Pruim R Xiao XY Li KN Conneely NL Riebow AG Sprau M Tong PP White KN Hetrick MW Barnhart CW Bark JL Goldstein L Watkins F Xiang J Saramies TA Buchanan RM Watanabe TT Valle L Kinnunen GR Abecasis EW Pugh KF Doheny RN Bergman J Tuomilehto FS Collins M Boehnke 2007 A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants Science 316 1341 1345
17. SK Service LA Sandkuijl NB Freimer 2003 Cost-effective designs for linkage disequilibrium mapping of complex traits Am J Hum Genet 72 1213 1220
18. Still CD, Benotti P, Wood GC, Gerhard G, Petrick A, Reed M, Strodel W (2007) Outcomes of preoperative weight loss in high-risk patients undergoing gastric bypass surgery. Arch Surg 142:994-998; discussion 999
19. K Thiru A Hassey F Sullivan 2003 Systematic review of scope and quality of electronic patient record data in primary care BMJ 326 1070
20. S Treweek 2003 The potential of electronic medical record systems to support quality improvement work and research in Norwegian general practice BMC Health Serv Res 3 10
21. J Voorham P Denig 2007 Computerized extraction of information on the quality of diabetes care from free text in electronic patient records of general practitioners J Am Med Inform Assoc 14 349 354
22. E Zeggini MN Weedon CM Lindgren TM Frayling KS Elliott H Lango NJ Timpson JR Perry NW Rayner RM Freathy JC Barrett B Shields AP Morris S Ellard CJ Groves LW Harries JL Marchini KR Owen B Knight LR Cardon M Walker GA Hitman AD Morris AS Doney MI McCarthy AT Hattersley 2007 Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes Science 316 1336 1341