The role of PACT in mediating gene induction, PKR activation, and apoptosis in response to diverse stimuli

Journal of Interferon and Cytokine Research

Volumn 28, Issue 8, 2008, Pages 469-475

  Marques, Joao T ^a,b   White, Christine L ^a   Peters, Gregory A ^a   Williams, Bryan R G ^c   Sen, Ganes C ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

^b NORTHWESTERN UNIVERSITY   (United States)

^c HUDSON INSTITUTE OF MEDICAL RESEARCH   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; DOUBLE STRANDED DNA; GAMMA INTERFERON; GROWTH FACTOR; INTERFERON REGULATORY FACTOR 3; PROTEIN KINASE R; PROTEIN PACT; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DEVELOPMENTAL DISORDER; ENCEPHALOMYOCARDITIS VIRUS; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE INDUCTION; KNOCKOUT MOUSE; MOUSE; NEWCASTLE DISEASE PARAMYXOVIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SENDAI VIRUS; STIMULUS RESPONSE; STRESS; VESICULAR STOMATITIS VIRUS; VIRUS INFECTION; WILD TYPE;

MUS;

EID: 50249156475     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2007.0006     Document Type: Article

References (30)

1. Abraham N, Stojdl DF, Duncan PI, Methot N, Ishii T, Dube M, Vanderhyden BC, Atkins HL, Gray DA, McBurney MW and others. 1999. Characterization of transgenic mice with targeted disruption of the catalytic domain of the double-stranded RNA-dependent protein kinase, PKR. J Biol Chem 274(9):5953-5962.
2. Bennett RL, Blalock WL, Abtahi DM, Pan Y, Moyer SA, May WS. 2006. RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy and viral infection. Blood 108(3):821-829.
3. Bennett RL, Blalock WL, May WS. 2004. Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition. J Biol Chem 279(41):42687-42693.
4. Chen G, Ma C, Bower KA, Ke Z, Luo J. 2006. Interaction between RAX and PKR modulates the effect of ethanol on protein synthesis and survival of neurons. J Biol Chem 281(23):15909-15915.
5. Fasciano S, Kaufman A, Patel RC. 2007. Expression of PACT is regulated by Sp1 transcription factor. Gene 388(1-2):74-82.
6. Gupta V, Huang X, Patel RC. 2003. The carboxy-terminal, M3 motifs of PACT and TRBP have opposite effects on PKR activity. Virology 315(2):283-291.
7. Huang X, Hutchins B, Patel RC. 2002. The C-terminal, third conserved motif of the protein activator PACT plays an essential role in the activation of double-stranded-RNA-dependent protein kinase (PKR). Biochem J 366(Pt 1):175-186.
8. Ito T, Yang M, May WS. 1999. RAX, a cellular activator for double-stranded RNA-dependent protein kinase during stress signaling. J Biol Chem 274(22):15427-15432.
9. Iwamura T, Yoneyama M, Koizumi N, Okabe Y, Namiki H, Samuel CE, Fujita T. 2001. PACT, a double-stranded RNA binding protein acts as a positive regulator for type I interferon gene induced by Newcastle disease virus. Biochem Biophys Res Commun 282(2):515-523.
10. Jiang HY, Wek SA, McGrath BC, Lu D, Hai T, Harding HP, Wang X, Ron D, Cavener DR, Wek RC. 2004. Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response. Mol Cell Biol 24(3):1365-1377.
11. Kawai T, Akira S. 2006. Innate immune recognition of viral infection. Nat Immunol 7(2):131-137.
12. Kok KH, Ng MH, Ching YP, Jin DY. 2007. Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA. J Biol Chem 282(24):17649-17657.
13. Kumar A, Yang YL, Flati V, Der S, Kadereit S, Deb A, Haque J, Reis L, Weissmann C, Williams BR. 1997. Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J 16(2):406-416.
14. Lee Y, Hur I, Park SY, Kim YK, Suh MR, Kim VN. 2006. The role of PACT in the RNA silencing pathway. EMBO J 25(3):522-532.
15. Li S, Sen GC. 2003. PACT-mediated enhancement of reporter gene expression at the translational level. J Interferon Cytokine Res 23(12):689-697.
16. Marques JT, Rebouillat D, Ramana CV, Murakami J, Hill JE, Gudkov A, Silverman RH, Stark GR, Williams BR. 2005. Down-regulation of p53 by double-stranded RNA modulates the antiviral response. J Virol 79(17):11105-11114.
17. Marques JT, Williams BR. 2005. Activation of the mammalian immune system by siRNAs. Nat Biotechnol 23(11):1399-1405.
18. Ohmori Y, Schreiber RD, Hamilton TA. 1997. Synergy between interferon-gamma and tumor necrosis factor-alpha in transcriptional activation is mediated by cooperation between signal transducer and activator of transcription 1 and nuclear factor kappaB. J Biol Chem 272(23):14899-14907.
19. Patel CV, Handy I, Goldsmith T, Patel RC. 2000. PACT, a stress-modulated cellular activator of interferon-induced double-stranded RNA-activated protein kinase, PKR. J Biol Chem 275(48):37993-37998.
20. Patel RC, Sen GC. 1998. PACT, a protein activator of the interferon-induced protein kinase, PKR. EMBO J 17(15):4379-4390.
21. Pei Y, Tuschl T. 2006. On the art of identifying effective and specific siRNAs. Nat Methods 3(9):670-676.
22. Peters GA, Hartmann R, Qin J, Sen GC. 2001. Modular structure of PACT: distinct domains for binding and activating PKR. Mol Cell Biol 21(6):1908-1920.
23. Peters GA, Khoo D, Mohr I, Sen GC. 2002. Inhibition of PACT-mediated activation of PKR by the herpes simplex virus type 1 Us11 protein. J Virol 76(21):11054-11064.
24. Rowe TM, Rizzi M, Hirose K, Peters GA, Sen GC. 2006. A role of the double-stranded RNA-binding protein PACT in mouse ear development and hearing. Proc Natl Acad Sci USA 103(15):5823-5828.
25. Ruvolo PP, Gao F, Blalock WL, Deng X, May WS. 2001. Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX. J Biol Chem 276(15):11754-11758.
26. Silva AM, Wang D, Komar AA, Castilho BA, Williams BR. 2007. Salicylates trigger protein synthesis inhibition in a protein kinase R-like endoplasmic reticulum kinase-dependent manner. J Biol Chem 282(14):10164-10171.
27. Terenzi F, Pal S, Sen GC. 2005. Induction and mode of action of the viral stress-inducible murine proteins, P56 and P54. Virology 340(1):116-124.
28. Williams BR. 2001. Signal integration via PKR. Sci STKE 89:RE2.
29. Yang M, Ito T, May WS. 2003. A novel role for RAX, the cellular activator of PKR, in synergistically stimulating SV40 large T antigen-dependent gene expression. J Biol Chem 278(40):38325-38332.
30. Yang YL, Reis LF, Pavlovic J, Aguzzi A, Schafer R, Kumar A, Williams BR, Aguet M, Weissmann C. 1995. Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J 14(24):6095-6106.