메뉴 건너뛰기




Volumn 88, Issue 9, 2008, Pages 910-925

Invasion suppressor cystatin E/M (CST6): High-level cell type-specific expression in normal brain and epigenetic silencing in gliomas

Author keywords

Cell invasion; CST6; Cystatin E M; DNA methylation; Glioma; Neural stem cell

Indexed keywords

CYSTATIN; CYSTATIN E; CYSTATIN M;

EID: 50249153514     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.66     Document Type: Article
Times cited : (55)

References (68)
  • 1
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nature Rev Genet 2002;3:662-673.
    • (2002) Nature Rev Genet , vol.3 , pp. 662-673
    • Li, E.1
  • 2
    • 0034744639 scopus 로고    scopus 로고
    • Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer
    • Baylin SB, Esteller M, Rountree MR, et al. Aberrant patterns of DNA methylation, chromatin formation and gene expression in cancer. Hum Mol Genet 2001;10:687-692.
    • (2001) Hum Mol Genet , vol.10 , pp. 687-692
    • Baylin, S.B.1    Esteller, M.2    Rountree, M.R.3
  • 3
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • Chen RZ, Pettersson U, Beard C, et al. DNA hypomethylation leads to elevated mutation rates. Nature 1998;395:89-93.
    • (1998) Nature , vol.395 , pp. 89-93
    • Chen, R.Z.1    Pettersson, U.2    Beard, C.3
  • 4
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A, Gaudet F, Waghmare A, et al. Chromosomal instability and tumors promoted by DNA hypomethylation. Science 2003;300:455.
    • (2003) Science , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3
  • 5
    • 0036274359 scopus 로고    scopus 로고
    • The fundamental role of epigenetic events in cancer
    • Jones PA, Baylin SB. The fundamental role of epigenetic events in cancer. Nature Rev Genet 2002;3:415-428.
    • (2002) Nature Rev Genet , vol.3 , pp. 415-428
    • Jones, P.A.1    Baylin, S.B.2
  • 6
    • 0343621494 scopus 로고    scopus 로고
    • Aberrant CpG-island methylation has a non-random and tumor-type-specific patterns
    • Costello JF, Fruhwald MC, Smiraglia DJ, et al. Aberrant CpG-island methylation has a non-random and tumor-type-specific patterns. Nature Genet 2000;25:132-138.
    • (2000) Nature Genet , vol.25 , pp. 132-138
    • Costello, J.F.1    Fruhwald, M.C.2    Smiraglia, D.J.3
  • 7
    • 0033558192 scopus 로고    scopus 로고
    • Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers
    • Bachman KE, Herman JG, Corn PG, et al. Methylation-associated silencing of the tissue inhibitor of metalloproteinase-3 gene suggests a suppressor role in kidney, brain, and other human cancers. Cancer Res 1999;59:798-802.
    • (1999) Cancer Res , vol.59 , pp. 798-802
    • Bachman, K.E.1    Herman, J.G.2    Corn, P.G.3
  • 8
    • 0037453906 scopus 로고    scopus 로고
    • Effects of 5-aza-2′- deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness
    • Sato N, Maehara N, Su SG, et al. Effects of 5-aza-2′- deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. J Natl Cancer Inst 2003;95:327-330.
    • (2003) J Natl Cancer Inst , vol.95 , pp. 327-330
    • Sato, N.1    Maehara, N.2    Su, S.G.3
  • 9
    • 0142182088 scopus 로고    scopus 로고
    • Cell-type specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells
    • Akiyama Y, Maesawa C, Ogasawara S, et al. Cell-type specific repression of the maspin gene is disrupted frequently by demethylation at the promoter region in gastric intestinal metaplasia and cancer cells. Am J Clin Pathol 2003;163:1911-1919.
    • (2003) Am J Clin Pathol , vol.163 , pp. 1911-1919
    • Akiyama, Y.1    Maesawa, C.2    Ogasawara, S.3
  • 10
    • 33747889966 scopus 로고    scopus 로고
    • Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma
    • Kim T-Y, Zhong S, Fields CR, et al. Epigenomic profiling reveals novel and frequent targets of aberrant DNA methylation-mediated silencing in malignant glioma. Cancer Res 2006;66:7490-7501.
    • (2006) Cancer Res , vol.66 , pp. 7490-7501
    • Kim, T.-Y.1    Zhong, S.2    Fields, C.R.3
  • 11
    • 33746163546 scopus 로고    scopus 로고
    • Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma
    • Foltz G, Ryu G-Y, Yoon J-G, et al. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res 2006;66:6665-6674.
    • (2006) Cancer Res , vol.66 , pp. 6665-6674
    • Foltz, G.1    Ryu, G.-Y.2    Yoon, J.-G.3
  • 12
    • 33746671852 scopus 로고    scopus 로고
    • The syk tyrosine kinase: A new negative regulator in tumor growth and progression
    • Coopman PJ, Mueller SC. The syk tyrosine kinase: a new negative regulator in tumor growth and progression. Canc Lett 2006;241:159-173.
    • (2006) Canc Lett , vol.241 , pp. 159-173
    • Coopman, P.J.1    Mueller, S.C.2
  • 13
    • 33845356420 scopus 로고    scopus 로고
    • Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets
    • Ordway JM, Bedell JA, Citek RW, et al. Comprehensive DNA methylation profiling in a human cancer genome identifies novel epigenetic targets. Carcinogenesis 2006;27:2409-2423.
    • (2006) Carcinogenesis , vol.27 , pp. 2409-2423
    • Ordway, J.M.1    Bedell, J.A.2    Citek, R.W.3
  • 14
    • 33745714230 scopus 로고    scopus 로고
    • Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms
    • Gore SD, Baylin S, Sugar E, et al. Combined DNA methyltransferase and histone deacetylase inhibition in the treatment of myeloid neoplasms. Cancer Res 2006;66:6361-6369.
    • (2006) Cancer Res , vol.66 , pp. 6361-6369
    • Gore, S.D.1    Baylin, S.2    Sugar, E.3
  • 15
    • 0038576158 scopus 로고    scopus 로고
    • The power and the promise of DNA methylation markers
    • Laird PW. The power and the promise of DNA methylation markers. Nature Rev Canc 2003;3:253-266.
    • (2003) Nature Rev Canc , vol.3 , pp. 253-266
    • Laird, P.W.1
  • 16
    • 5044224775 scopus 로고    scopus 로고
    • DNA-microarray analysis of brain cancer: Molecular classification for therapy
    • Mischel PS, Cloughesy TF, Nelson SF. DNA-microarray analysis of brain cancer: molecular classification for therapy. Nat Rev Neurosci 2004;5:782-792.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 782-792
    • Mischel, P.S.1    Cloughesy, T.F.2    Nelson, S.F.3
  • 17
    • 14244265590 scopus 로고    scopus 로고
    • Epidemiology and etiology of gliomas
    • Ohgaki H, Kleihues P. Epidemiology and etiology of gliomas. Acta Neuropathol 2005;109:93-108.
    • (2005) Acta Neuropathol , vol.109 , pp. 93-108
    • Ohgaki, H.1    Kleihues, P.2
  • 18
    • 13444275480 scopus 로고    scopus 로고
    • Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion
    • Bellail AC, Hunter SB, Brat DJ, et al. Microregional extracellular matrix heterogeneity in brain modulates glioma cell invasion. Int J Biochem Cell Biol 2004;36:1046-1069.
    • (2004) Int J Biochem Cell Biol , vol.36 , pp. 1046-1069
    • Bellail, A.C.1    Hunter, S.B.2    Brat, D.J.3
  • 19
    • 50249108067 scopus 로고    scopus 로고
    • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumors of the Central Nervous System. International Agency for Research on Cancer, 4th edn. IARC Press: Lyon, 2007.
    • Louis DN, Ohgaki H, Wiestler OD, Cavenee WK. WHO Classification of Tumors of the Central Nervous System. International Agency for Research on Cancer, 4th edn. IARC Press: Lyon, 2007.
  • 20
    • 0034987702 scopus 로고    scopus 로고
    • Malignant glioma: Genetics and biology of a grave matter
    • Maher EA, Funari FB, Bachoo RM, et al. Malignant glioma: genetics and biology of a grave matter. Genes Dev 2001;15:1311-1333.
    • (2001) Genes Dev , vol.15 , pp. 1311-1333
    • Maher, E.A.1    Funari, F.B.2    Bachoo, R.M.3
  • 21
    • 4143103637 scopus 로고    scopus 로고
    • Epidemiology of brain tumors in childhood - a review
    • Baldwin RT, Preston-Martin S. Epidemiology of brain tumors in childhood - a review. Toxicol Appl Pharmacol 2004;199:118-131.
    • (2004) Toxicol Appl Pharmacol , vol.199 , pp. 118-131
    • Baldwin, R.T.1    Preston-Martin, S.2
  • 22
    • 9144241696 scopus 로고    scopus 로고
    • Molecular pathogenesis of childhood brain tumors
    • Pietsch T, Taylor MD, Rutka JT. Molecular pathogenesis of childhood brain tumors. J Neurooncol 2004;70:203-215.
    • (2004) J Neurooncol , vol.70 , pp. 203-215
    • Pietsch, T.1    Taylor, M.D.2    Rutka, J.T.3
  • 23
    • 0037678573 scopus 로고    scopus 로고
    • Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas
    • Alonso ME, Bello MJ, Gonzalez-Gomez P, et al. Aberrant promoter methylation of multiple genes in oligodendrogliomas and ependymomas. Cancer Genet Cytogenet 2003;144:134-142.
    • (2003) Cancer Genet Cytogenet , vol.144 , pp. 134-142
    • Alonso, M.E.1    Bello, M.J.2    Gonzalez-Gomez, P.3
  • 24
    • 0642347746 scopus 로고    scopus 로고
    • Epigenetic changes in pilocytic astrocytomas and medulloblastomas
    • Gonzalez-Gomez P, Bello MJ, Lomas J, et al. Epigenetic changes in pilocytic astrocytomas and medulloblastomas. Int J Mol Med 2003;11:655-660.
    • (2003) Int J Mol Med , vol.11 , pp. 655-660
    • Gonzalez-Gomez, P.1    Bello, M.J.2    Lomas, J.3
  • 25
    • 0041737535 scopus 로고    scopus 로고
    • Molecular mechanisms of glioma invasiveness: The role of proteases
    • Rao JS. Molecular mechanisms of glioma invasiveness: the role of proteases. Nature Rev Canc 2003;3:489-501.
    • (2003) Nature Rev Canc , vol.3 , pp. 489-501
    • Rao, J.S.1
  • 26
    • 0036294944 scopus 로고    scopus 로고
    • Lysosomal enzymes, cathepsins in brain tumour invasion
    • Levicar N, Strijnik T, Kos J, et al. Lysosomal enzymes, cathepsins in brain tumour invasion. J Neurooncol 2002;58:21-32.
    • (2002) J Neurooncol , vol.58 , pp. 21-32
    • Levicar, N.1    Strijnik, T.2    Kos, J.3
  • 27
    • 0035927499 scopus 로고    scopus 로고
    • Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells
    • Mohanam S, Jasti SL, Kondraganti SR, et al. Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene 2001;20:3665-3673.
    • (2001) Oncogene , vol.20 , pp. 3665-3673
    • Mohanam, S.1    Jasti, S.L.2    Kondraganti, S.R.3
  • 28
    • 1842538729 scopus 로고    scopus 로고
    • Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis
    • Yanamandra N, Gumidyala KV, Waldron KG, et al. Blockade of cathepsin B expression in human glioblastoma cells is associated with suppression of angiogenesis. Oncogene 2004;23:2224-2230.
    • (2004) Oncogene , vol.23 , pp. 2224-2230
    • Yanamandra, N.1    Gumidyala, K.V.2    Waldron, K.G.3
  • 29
    • 0028896583 scopus 로고
    • Overexpression and localization of cathepsin B during the progression of human gliomas
    • Sivaparvathi M, Sawaya R, Wang SW, et al. Overexpression and localization of cathepsin B during the progression of human gliomas. Clin Exp Metastasis 1995;13:49-56.
    • (1995) Clin Exp Metastasis , vol.13 , pp. 49-56
    • Sivaparvathi, M.1    Sawaya, R.2    Wang, S.W.3
  • 30
    • 0029877274 scopus 로고    scopus 로고
    • Expression of cathepsin D during the progression of human gliomas
    • Sivaparvathi M, Sawaya R, Chintala SK, et al. Expression of cathepsin D during the progression of human gliomas. Neurosci Lett 1996;208:171-174.
    • (1996) Neurosci Lett , vol.208 , pp. 171-174
    • Sivaparvathi, M.1    Sawaya, R.2    Chintala, S.K.3
  • 31
    • 50249137909 scopus 로고    scopus 로고
    • Abrahamson M, Alvarez-Fernandez M, Nathanson C-M. Cystatins
    • Abrahamson M, Alvarez-Fernandez M, Nathanson C-M. Cystatins.
  • 32
    • 3042696486 scopus 로고    scopus 로고
    • Biochem Soc Symp 2003;70:179-199.
    • (2003) Biochem Soc Symp , vol.70 , pp. 179-199
  • 33
    • 0036316450 scopus 로고    scopus 로고
    • Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation
    • Hong J, Yoshida K, Rosner MR. Characterization of a cysteine proteinase inhibitor induced during neuronal cell differentiation. J Neurochem 2002;81:922-934.
    • (2002) J Neurochem , vol.81 , pp. 922-934
    • Hong, J.1    Yoshida, K.2    Rosner, M.R.3
  • 34
    • 0030890648 scopus 로고    scopus 로고
    • Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins
    • Ni J, Abrahamson M, Zhang M, et al. Cystatin E is a novel human cysteine proteinase inhibitor with structural resemblance to family 2 cystatins. J Biol Chem 1997;272:10853-10858.
    • (1997) J Biol Chem , vol.272 , pp. 10853-10858
    • Ni, J.1    Abrahamson, M.2    Zhang, M.3
  • 35
    • 1842591219 scopus 로고    scopus 로고
    • Cystatin M suppresses the malignant phenotype of human MDA-MD-435S cells
    • Shridhar R, Zhang J, Song J, et al. Cystatin M suppresses the malignant phenotype of human MDA-MD-435S cells. Oncogene 2004;23:2206-2215.
    • (2004) Oncogene , vol.23 , pp. 2206-2215
    • Shridhar, R.1    Zhang, J.2    Song, J.3
  • 36
    • 4944252978 scopus 로고    scopus 로고
    • Cystatin M: A novel candidate tumor suppressor gene for breast cancer
    • Zhang J, Shridhar R, Dai Q, et al. Cystatin M: a novel candidate tumor suppressor gene for breast cancer. Cancer Res 2004;64:6957-6964.
    • (2004) Cancer Res , vol.64 , pp. 6957-6964
    • Zhang, J.1    Shridhar, R.2    Dai, Q.3
  • 37
    • 0344549791 scopus 로고    scopus 로고
    • Isolation and characterization of neural progenitor cells from post-mortem human cortex
    • Schwartz PH, Bryant PJ, Fuja TJ, et al. Isolation and characterization of neural progenitor cells from post-mortem human cortex. J Neurosci Res 2003;74:838-851.
    • (2003) J Neurosci Res , vol.74 , pp. 838-851
    • Schwartz, P.H.1    Bryant, P.J.2    Fuja, T.J.3
  • 38
    • 33646358694 scopus 로고    scopus 로고
    • Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines
    • Lee J, Kotliarova S, Kotliarov Y, et al. Tumor stem cells derived from glioblastomas cultured in bFGF and EGF more closely mirror the phenotype and genotype of primary tumors than do serum-cultured cell lines. Cancer Cell 2006;9:391-403.
    • (2006) Cancer Cell , vol.9 , pp. 391-403
    • Lee, J.1    Kotliarova, S.2    Kotliarov, Y.3
  • 40
    • 0031822837 scopus 로고    scopus 로고
    • Tissue microarrays for high-throughput molecular profiling of tumor specimens
    • Kononen J, Bubendorf L, Kallioniemi A, et al. Tissue microarrays for high-throughput molecular profiling of tumor specimens. Nature Med 1998;4:844-847.
    • (1998) Nature Med , vol.4 , pp. 844-847
    • Kononen, J.1    Bubendorf, L.2    Kallioniemi, A.3
  • 41
    • 33748041100 scopus 로고    scopus 로고
    • Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression
    • Ai L, Kim W-J, Kim T-Y, et al. Epigenetic silencing of the tumor suppressor cystatin M occurs during breast cancer progression. Cancer Res 2006;66:7899-7909.
    • (2006) Cancer Res , vol.66 , pp. 7899-7909
    • Ai, L.1    Kim, W.-J.2    Kim, T.-Y.3
  • 42
    • 34347358566 scopus 로고    scopus 로고
    • Highly efficient neuronal differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery
    • Widera D, Grimm W-D, Moebius JM, et al. Highly efficient neuronal differentiation of human somatic stem cells, isolated by minimally invasive periodontal surgery. Stem Cells Dev 2007;16:447-460.
    • (2007) Stem Cells Dev , vol.16 , pp. 447-460
    • Widera, D.1    Grimm, W.-D.2    Moebius, J.M.3
  • 43
    • 33646067439 scopus 로고    scopus 로고
    • Towards novel anti-cancer strategies based on cystatin function
    • Keppler D. Towards novel anti-cancer strategies based on cystatin function. Canc Lett 2006;235:159-176.
    • (2006) Canc Lett , vol.235 , pp. 159-176
    • Keppler, D.1
  • 44
    • 0026546877 scopus 로고
    • A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands
    • Frommer M, McDonald LE, Millar DS, et al. A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands. Proc Natl Acad Sci USA 1992;89:1827-1831.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1827-1831
    • Frommer, M.1    McDonald, L.E.2    Millar, D.S.3
  • 45
    • 0024555756 scopus 로고
    • Identification of an adult-specific glial progenitor cell
    • Wolswijk G, Noble M. Identification of an adult-specific glial progenitor cell. Development 1989;105:387-400.
    • (1989) Development , vol.105 , pp. 387-400
    • Wolswijk, G.1    Noble, M.2
  • 46
    • 0029843950 scopus 로고    scopus 로고
    • Methylation-specific PCR: A novel assay for methylation status of CpG islands
    • Herman JG, Graff JR, Myohanen S, et al. Methylation-specific PCR: a novel assay for methylation status of CpG islands. Proc Natl Acad Sci USA 1996;93:9821-9826.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 9821-9826
    • Herman, J.G.1    Graff, J.R.2    Myohanen, S.3
  • 47
    • 38449113853 scopus 로고    scopus 로고
    • DNA methylation analysis by pyrosequencing
    • Tost J, Gut IG. DNA methylation analysis by pyrosequencing. Nat Protoc 2007;2:2265-2275.
    • (2007) Nat Protoc , vol.2 , pp. 2265-2275
    • Tost, J.1    Gut, I.G.2
  • 48
    • 35848934352 scopus 로고    scopus 로고
    • Neural stem cells, tumour stem cells, and brain tumours: Dangerous relationships?
    • Sutter R, Yadirgi G, Marino S. Neural stem cells, tumour stem cells, and brain tumours: Dangerous relationships? Biochim Biophys Acta 2007;1776:125-137.
    • (2007) Biochim Biophys Acta , vol.1776 , pp. 125-137
    • Sutter, R.1    Yadirgi, G.2    Marino, S.3
  • 49
    • 40749111022 scopus 로고    scopus 로고
    • Genomic changes and gene expression profiles reveal that established glioma lines are poorly representative of primary human gliomas
    • Li A, Walling J, Kotliarov Y, et al. Genomic changes and gene expression profiles reveal that established glioma lines are poorly representative of primary human gliomas. Mol Canc Res 2008;6:21-30.
    • (2008) Mol Canc Res , vol.6 , pp. 21-30
    • Li, A.1    Walling, J.2    Kotliarov, Y.3
  • 51
    • 0032948005 scopus 로고    scopus 로고
    • Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer
    • Cameron EE, Bachman KE, Myohanen S, et al. Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer. Nature Genet 1999;21:103-107.
    • (1999) Nature Genet , vol.21 , pp. 103-107
    • Cameron, E.E.1    Bachman, K.E.2    Myohanen, S.3
  • 52
    • 33744915019 scopus 로고    scopus 로고
    • Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification
    • Cheng T, Hitomi K, van Vlijmen-Willems IM, et al. Cystatin M/E is a high affinity inhibitor of cathepsin V and cathepsin L by a reactive site that is distinct from the legumain-binding site. A novel clue for the role of cystatin M/E in epidermal cornification. J Biol Chem 2006;281:15893-15899.
    • (2006) J Biol Chem , vol.281 , pp. 15893-15899
    • Cheng, T.1    Hitomi, K.2    van Vlijmen-Willems, I.M.3
  • 53
    • 1942470581 scopus 로고    scopus 로고
    • A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor
    • Goulet B, Baruch A, Moon NS, et al. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol Cell 2004;14:207-219.
    • (2004) Mol Cell , vol.14 , pp. 207-219
    • Goulet, B.1    Baruch, A.2    Moon, N.S.3
  • 54
    • 33750619248 scopus 로고    scopus 로고
    • Hook VY. Unique neuronal functions of cathepsin L and B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biol Chem 2006;384:1429-1439. 54. Rivenbark AG, Jones WD, Coleman WB. DNA methylation-dependent silencing of CST6 in human breast cancer cell lines. Lab Invest 2006;86:1233-1242.
    • Hook VY. Unique neuronal functions of cathepsin L and B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease. Biol Chem 2006;384:1429-1439. 54. Rivenbark AG, Jones WD, Coleman WB. DNA methylation-dependent silencing of CST6 in human breast cancer cell lines. Lab Invest 2006;86:1233-1242.
  • 55
    • 34248324754 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of cystatin M in breast carcinoma
    • Schagdarsurengin U, Pfeifer GP, Dammann R. Frequent epigenetic inactivation of cystatin M in breast carcinoma. Oncogene 2007;26:3089-3094.
    • (2007) Oncogene , vol.26 , pp. 3089-3094
    • Schagdarsurengin, U.1    Pfeifer, G.P.2    Dammann, R.3
  • 56
    • 34247373911 scopus 로고    scopus 로고
    • Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer
    • Zhong S, Fields CR, Su N, et al. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer. Oncogene 2007;26:2621-2634.
    • (2007) Oncogene , vol.26 , pp. 2621-2634
    • Zhong, S.1    Fields, C.R.2    Su, N.3
  • 57
    • 0029902931 scopus 로고    scopus 로고
    • Expression of cysteine protease inhibitors in human gliomas and meningiomas
    • Sivaparvathi M, Mc Cutcheon I, Sawaya R, et al. Expression of cysteine protease inhibitors in human gliomas and meningiomas. Clin Exp Metastasis 1996;14:344-350.
    • (1996) Clin Exp Metastasis , vol.14 , pp. 344-350
    • Sivaparvathi, M.1    Mc Cutcheon, I.2    Sawaya, R.3
  • 58
    • 0037069925 scopus 로고    scopus 로고
    • Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells
    • Konduri SD, Yanamandra N, Siddique K, et al. Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells. Oncogene 2002;21:8705-8712.
    • (2002) Oncogene , vol.21 , pp. 8705-8712
    • Konduri, S.D.1    Yanamandra, N.2    Siddique, K.3
  • 59
    • 0029097797 scopus 로고
    • Immunolocalization of cathepsin B in human glioma: Implications for tumor invasion and angiogenesis
    • Mikkelsen T, Yan PS, Ho KL, et al. Immunolocalization of cathepsin B in human glioma: implications for tumor invasion and angiogenesis. J Neurosurg 1995;83:285-290.
    • (1995) J Neurosurg , vol.83 , pp. 285-290
    • Mikkelsen, T.1    Yan, P.S.2    Ho, K.L.3
  • 60
    • 2942718949 scopus 로고    scopus 로고
    • Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis
    • Lakka SS, Gondi CS, Yanamandra N, et al. Inhibition of cathepsin B and MMP-9 gene expression in glioblastoma cell line via RNA interference reduces tumor cell invasion, tumor growth and angiogenesis. Oncogene 2004;23:4681-4689.
    • (2004) Oncogene , vol.23 , pp. 4681-4689
    • Lakka, S.S.1    Gondi, C.S.2    Yanamandra, N.3
  • 61
    • 0027999772 scopus 로고
    • Cathepsin B expression and localization in glioma progression and invasion
    • Rempel SA, Rosenblum ML, Mikkelsen T, et al. Cathepsin B expression and localization in glioma progression and invasion. Cancer Res 1994;54:6027-6031.
    • (1994) Cancer Res , vol.54 , pp. 6027-6031
    • Rempel, S.A.1    Rosenblum, M.L.2    Mikkelsen, T.3
  • 62
    • 37349067098 scopus 로고    scopus 로고
    • Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells
    • Lee J, Son MJ, Woolard K, et al. Epigenetic-mediated dysfunction of the bone morphogenetic protein pathway inhibits differentiation of glioblastoma-initiating cells. Cancer Cell 2008;13:69-80.
    • (2008) Cancer Cell , vol.13 , pp. 69-80
    • Lee, J.1    Son, M.J.2    Woolard, K.3
  • 63
    • 33845317573 scopus 로고    scopus 로고
    • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response
    • Bao S, Wu Q, Mc Lendon RE, et al. Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. Nature 2006;444:756-760.
    • (2006) Nature , vol.444 , pp. 756-760
    • Bao, S.1    Wu, Q.2    Mc Lendon, R.E.3
  • 64
  • 65
    • 29244477512 scopus 로고    scopus 로고
    • The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin
    • Song J, Jie C, Polk P, et al. The candidate tumor suppressor CST6 alters the gene expression profile of human breast carcinoma cells: Down-regulation of the potent mitogenic, motogenic, and angiogenic factor autotaxin. Biochem Biophys Res Commun 2006;340:175-182.
    • (2006) Biochem Biophys Res Commun , vol.340 , pp. 175-182
    • Song, J.1    Jie, C.2    Polk, P.3
  • 66
    • 30544439044 scopus 로고    scopus 로고
    • Silencing of cystatin M in metastatic oral cancer line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion
    • Vigneswaran N, Wu J, Nagaraj N, et al. Silencing of cystatin M in metastatic oral cancer line MDA-686Ln by siRNA increases cysteine proteinases and legumain activities, cell proliferation and in vitro invasion. Life Sciences 2006;78:898-907.
    • (2006) Life Sciences , vol.78 , pp. 898-907
    • Vigneswaran, N.1    Wu, J.2    Nagaraj, N.3
  • 67
    • 0033635021 scopus 로고    scopus 로고
    • FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor
    • Taupin P, Ray J, Fischer WH, et al. FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron 2000;28:385-397.
    • (2000) Neuron , vol.28 , pp. 385-397
    • Taupin, P.1    Ray, J.2    Fischer, W.H.3
  • 68
    • 4444304939 scopus 로고    scopus 로고
    • Regulation of matrix biology by matrix metalloproteinases
    • Mott JD, Werb Z. Regulation of matrix biology by matrix metalloproteinases. Curr Opin Cell Biol 2004;16:558-564.
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 558-564
    • Mott, J.D.1    Werb, Z.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.