IL-4 inhibits cell cycle progression of human umbilical vein endothelial cells by affecting p53, p21Waf1, cyclin D1, and cyclin E expression

Molecules and Cells

Volumn 16, Issue 1, 2003, Pages 92-96

  Kim, Jinkoo ^a,b   Cheon, In Su ^a,b   Won, Yu Jin ^a,b   Na, Hee Jun ^a,b   Kim, Young Myeong ^a,b   Choe, Jongseon ^a,b  

^a Kangwon National University   (South Korea)

^b Kangwon National University College of Medicine   (South Korea)

Author keywords

Cell Cycle Arrest; Cyclin; HUVEC; IL 4; p21

Indexed keywords

CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; FIBROBLAST GROWTH FACTOR 2; INTERLEUKIN 4; PROTEIN P53; VASCULOTROPIN; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLINE; VASCULOTROPIN A;

ANTIANGIOGENIC ACTIVITY; ARTICLE; CELL CYCLE; CELL GROWTH; DIPLOIDY; DRUG INHIBITION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PROTEIN EXPRESSION; UMBILICAL VEIN; CELL CULTURE; CYTOLOGY; METABOLISM; PHYSIOLOGY;

CELL CYCLE; CELLS, CULTURED; CYCLIN D1; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; ENDOTHELIAL CELLS; FIBROBLAST GROWTH FACTOR 2; HUMANS; INTERLEUKIN-4; TUMOR SUPPRESSOR PROTEIN P53; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 3042742916     PISSN: 10168478     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (25)

1. Carteron, N. L. (2000) Cytokines in rheumatoid arthritis: trials and tribulations. Mol. Med. Today 6, 315-323.
2. Cho, C. S., Cho, M. L., Min, S. Y., Kim, W. U., Min, D. J., Lee, S. S., Pak, S. H., Choe, J., and Kim, H. Y. (2000) CD40 engagement on synovial fibroblast up-regulates production of vascular endothelial growth factor. J. Immunol. 164, 5055-5061.
3. Dechanet, J., Briolay, J., Rissoan, M.-C., Chomarat, P., Galizzi, J.-P., Banchereau, J., and Miossec, P. (1993) IL-4 inhibits growth factor-stimulated rheumatoid synoviocyte proliferation by blocking the early phases of the cell cycle. J. Immunol. 151, 4908-4917.
4. Eriksson, U. and Alitalo, K. (2002) VEGF receptor 1 stimulates stem-cell recruitment and new hope for angiogenesis therapies. Nat. Med. 8, 775-777.
5. Estes, M. L., Iwasaki, K., Jacobs, B. S., and Barna, B. P. (1993) Interleukin-4 down-regulates adult human astrocyte DNA synthesis and proliferation. Am. J. Pathol. 143, 337-341.
6. Firestein, G. S. (1999) Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis. J. Clin. Invest. 103, 3-4.
7. Hata, Y., Rook, S. L., and Aiello, L. P. (1999) Basic fibroblast growth factor induces expression of VEGF receptor KDR through a protein kinase C and p44/p42 mitogen-activated protein kinase-dependent pathway. Diabetes 48, 1145-1155.
8. Kim, Y. M., de Vera, M. E., Watkins, S. C., and Billiar, T. R. (1997) Nitric oxide protects cultured rat hepatocytes from tumor necrosis factor-alpha-induced apoptosis by inducing heat shock protein 70 expression. J. Biol. Chem. 272, 1402-1411.
9. Klein, N. J., Rigley, K. P., and Callard, R. E. (1993) IL-4 regulates the morphology, cytoskeleton, and proliferation of human umbilical vein endothelial cells: relationship between vimentin and CD23. Int. Immunol. 5, 293-301.
10. Koch, A. E., Harlow, L. A., Haines, G. K., Amento, E. P., Unemori, E. N., Wong, W. L., Pope, R. M., and Ferrara, N. (1994) Vascular endothelial growth factor. A cytokine modulating endothelial function in rheumatoid arthritis. J. Immunol. 152, 4149-4156.
11. Lee, I. Y., Kim, J., Ko, E.-M., Jeoung, E. J., Kwon, Y.-G., and Choe, J. (2002) Interleukin-4 inhibits the vascular endothelical growth factor- and basic fibroblast growth factor-induced angiogenesis in vitro. Mol. Cells 14, 115-121.
12. Lee, Y. W., Kuhn, H., Hennig, B., and Toborek, M. (2000) IL-4 induces apoptosis of endothelial cells through the caspase-3-dependent pathway. FEBS Lett. 485, 122-126.
13. Liu, J., Estes, M. L., Drazba, J. A., Liu, H., Prayson, R., Kondo, S., Jacobs, B. S., Barnett, G. H., and Barna, B. P. (2000) Anti-sense oligonucleotide of p21(waf1/cip1) prevents interleukin 4-mediated elevation of p27(kip1) in low grade astrocytoma cells. Oncogene 19, 661-669.
14. Lubberts, E., Joosten, L. A. B., van den Bersselaar, L., Helsen, M. M. A., Bakker, A. C., van Meurs, J. B. J., Graham, F. L., Richards, C. D., and van den Berg, W. B. (1999) Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction. J. Immunol. 163, 4546-4556.
15. Nagy, J. A., Vasile, E., Feng, D., Sundberg, C., Brown, L. F., Detmar, M. J., Lawitts, J. A., Benjamin, L., Tan, X., Manseau, E. J., Dvorak, A. M., and Dvorak, H. F. (2002) Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis. J. Exp. Med. 196, 1497-1506.
16. Paul, W. E. (1991) Interleukin-4: a prototypic immunoregulatory cytokine. Blood 77, 1859-1870.
17. Pestell, R. G., Albanese, C., Reutens, A. T., Segall, J. E., Lee, R. J., and Arnold, A. (1999) The cyclins and cyclin-dependent kinase inhibitors in hormonal regulation of proliferation and differentiation. Endocr. Rev. 20, 501-534.
18. Pietenpol, J. A. and Stewart, Z. A. (2002) Cell cycle checkpoint signaling: cell cycle arrest versus apoptosis. Toxicology 181-182, 475-481.
19. Röcken, M., Rocke, M., and Shevach, E. M. (1996) IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease. Immunol. Today 17, 225-231.
20. Salcedo, R., Wasserman, K., Young, H. A., Grimm, M. C., Howard, O. M. Z., Anver, M. R., Kleinman, H. K., Murphy, W. J., and Oppenheim, J. J. (1999) Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells. Am. J. Pathol. 154, 1125-1135.
21. Saleh, M., Davis, I. D., and Wilks, A. F. (1997) The paracrine role of tumor-derived mIL-4 on tumor-associated endothelium. Int. J. Cancer 72, 664-672.
22. Siepmann, K., Wohlleben, G., and Gray, D. (1996) CD40-mediated regulation of interleukin-4 signaling pathways in B lymphocytes. Eur. J. Immunol. 26, 1544-1552.
23. St. Croix, B., Rago, C., Velculescu, V., Traverse, G., Romans, K. E., Montgomery, E., Lal, A., Riggins, G. J., Lengauer, C., Vogelstein, B., and Kinzler, K. W. (2000) Genes expressed in human tumor endothelium. Science 289, 1197-1202.
24. Volpert, O. V., Fong, T., Koch, A. E., Peterson, J. D., Waltenbaugh, C., Tepper, R. I., and Bouck, N. P. (1998) Inhibition of angiogenesis by interleukin 4. J. Exp. Med. 188, 1039-1046.
25. Volpert, O. V., Zaichuk, T., Zhou, W., Reiher, F., Ferguson, T. A., Stuart, P. M., Amin, M., and Bouck, N. P. (2002) Inducer-stimulated Fas targets activated endothelium for destruction by anti-angiogenic thrombospondin-1 and pigment epithelium-derived factor. Nat. Med. 8, 349-357.