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Volumn 25, Issue 9, 2008, Pages 761-775

Transdermal delivery of treatment for Alzheimer's disease: Development, clinical performance and future prospects

Author keywords

Acetylcholinesterase inhibitors, therapeutic use; Alzheimer's disease, treatment; Estradiol, therapeutic use; Muscarinic receptor agonists, therapeutic use; Nicotine, therapeutic use; Phenserine, therapeutic use; Physostigmine, therapeutic use

Indexed keywords

ESTRADIOL; HOMOTAURINE; LEUPRORELIN; NICOTINE; PHENSERINE; PHYSOSTIGMINE; RIVASTIGMINE; TACRINE; TARENFLURBIL; XALIPRODEN;

EID: 50249113134     PISSN: 1170229X     EISSN: None     Source Type: Journal    
DOI: 10.2165/00002512-200825090-00003     Document Type: Review
Times cited : (27)

References (101)
  • 1
    • 50249124397 scopus 로고    scopus 로고
    • Novartis media factsheet, online, Available from URL:, Accessed 2008 Jul 11
    • Novartis media factsheet. Exelon® patch, a new therapeutic approach [online]. Available from URL: http://www.lif.se/cs/Publik%20webb/Sidinnehall/ Publik_Dokument/Pressmeddelanden/FACTS_ABOUT_THE_EXELON_PATCH.doc [Accessed 2008 Jul 11]
    • Exelon® patch, a new therapeutic approach
  • 2
    • 0042023711 scopus 로고    scopus 로고
    • Alzheimer disease in the US population: Prevalence estimates using the 2000 census
    • Hebert LE, Scherr PA, Bienias JL, et al. Alzheimer disease in the US population: prevalence estimates using the 2000 census. Arch Neurol 2003; 60: 1119-22
    • (2003) Arch Neurol , vol.60 , pp. 1119-1122
    • Hebert, L.E.1    Scherr, P.A.2    Bienias, J.L.3
  • 3
    • 50249128574 scopus 로고    scopus 로고
    • Use your faculties and Alzheimer's can be kept at bay
    • 15
    • Chou J. Use your faculties and Alzheimer's can be kept at bay. Taipei Times 2005; 15: 1-2
    • (2005) Taipei Times , pp. 1-2
    • Chou, J.1
  • 4
    • 32044447659 scopus 로고    scopus 로고
    • An estimate of the worldwide prevalence and direct costs of dementia in 2003
    • Wimo A, Jonsson L, Winblad B. An estimate of the worldwide prevalence and direct costs of dementia in 2003. Dement Geriatr Cogn Disord 2006; 21: 175-81
    • (2006) Dement Geriatr Cogn Disord , vol.21 , pp. 175-181
    • Wimo, A.1    Jonsson, L.2    Winblad, B.3
  • 5
    • 0038308812 scopus 로고    scopus 로고
    • Inhibition of human cholinesterases by drugs used to treat Alzheimer disease
    • Darvesh S, Walsh R, Kumar R, et al. Inhibition of human cholinesterases by drugs used to treat Alzheimer disease. Alzheimer Dis Assoc Disord 2003; 17 (2): 117-26
    • (2003) Alzheimer Dis Assoc Disord , vol.17 , Issue.2 , pp. 117-126
    • Darvesh, S.1    Walsh, R.2    Kumar, R.3
  • 6
    • 0018129338 scopus 로고
    • Changes in brain cholinesterases in senile dementia of Alzheimer type
    • Perry EK, Perry RH, Blessed G, et al. Changes in brain cholinesterases in senile dementia of Alzheimer type. Neuropathol Appl Neurobiol 1978; 4: 273-7
    • (1978) Neuropathol Appl Neurobiol , vol.4 , pp. 273-277
    • Perry, E.K.1    Perry, R.H.2    Blessed, G.3
  • 8
    • 0344098999 scopus 로고    scopus 로고
    • Should titration schedules for cholinesterase inhibitors be changed?
    • Sikdar S. Should titration schedules for cholinesterase inhibitors be changed? Int J Geriatr Psychiatry 2003; 18: 1063-4
    • (2003) Int J Geriatr Psychiatry , vol.18 , pp. 1063-1064
    • Sikdar, S.1
  • 9
    • 0033528436 scopus 로고    scopus 로고
    • Efficacy and safety of rivastigmine in patients with Alzheimer's disease: International randomized controlled trial
    • Rosler M, Anand R, Cicin-Sain A, et al. Efficacy and safety of rivastigmine in patients with Alzheimer's disease: international randomized controlled trial. BMJ 1999; 318 (6): 633-40
    • (1999) BMJ , vol.318 , Issue.6 , pp. 633-640
    • Rosler, M.1    Anand, R.2    Cicin-Sain, A.3
  • 10
    • 42749100518 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • CD005593
    • Birks J. Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev 2006; 25 (1): CD005593
    • (2006) Cochrane Database Syst Rev , vol.25 , Issue.1
    • Birks, J.1
  • 11
    • 34249683625 scopus 로고    scopus 로고
    • A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease: Rivastigmine patch versus capsule
    • Winblad B, Cumming J, Andreasen N, et al. A six-month double-blind, randomized, placebo-controlled study of a transdermal patch in Alzheimer's disease: rivastigmine patch versus capsule. Int J Geriatr Psychiatry 2007; 32 (5): 456-67
    • (2007) Int J Geriatr Psychiatry , vol.32 , Issue.5 , pp. 456-467
    • Winblad, B.1    Cumming, J.2    Andreasen, N.3
  • 12
    • 33947375500 scopus 로고    scopus 로고
    • Preclinical investigation of the topical administration of phenserine: Transdermal flux, cholinesterase inhibition, and cognitive efficacy
    • Utsuki T, Uchimura N, Irikura M, et al. Preclinical investigation of the topical administration of phenserine: transdermal flux, cholinesterase inhibition, and cognitive efficacy. J Pharmacol Exp Ther 2007; 321 (1): 353-61
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.1 , pp. 353-361
    • Utsuki, T.1    Uchimura, N.2    Irikura, M.3
  • 13
    • 30844446707 scopus 로고    scopus 로고
    • Circadian cholinergic rhythms: Implications for cholinesterase inhibitor therapy
    • Davis B. Circadian cholinergic rhythms: implications for cholinesterase inhibitor therapy. Dement Geriatr Cogn Disord 2006; 21 (2): 120-9
    • (2006) Dement Geriatr Cogn Disord , vol.21 , Issue.2 , pp. 120-129
    • Davis, B.1
  • 14
    • 50249149374 scopus 로고    scopus 로고
    • Transdermal drug delivery systems. In: Allen Jr LV, Popovich NG, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. 8th ed. Philadelphia (PA): Lippincott Williams and Willkins, 2004: 298-315
    • Transdermal drug delivery systems. In: Allen Jr LV, Popovich NG, Ansel HC. Ansel's pharmaceutical dosage forms and drug delivery systems. 8th ed. Philadelphia (PA): Lippincott Williams and Willkins, 2004: 298-315
  • 15
    • 0032872962 scopus 로고    scopus 로고
    • Double-blind, randomized, placebo-controlled clinical trial on the efficacy and tolerability of a physostigmine patch in patients with senile dementia of the Alzheimer type
    • Moller HJ, Hampel H, Hegerl U, et al. Double-blind, randomized, placebo-controlled clinical trial on the efficacy and tolerability of a physostigmine patch in patients with senile dementia of the Alzheimer type. Pharmacopsychiatry 1999; 32: 99-106
    • (1999) Pharmacopsychiatry , vol.32 , pp. 99-106
    • Moller, H.J.1    Hampel, H.2    Hegerl, U.3
  • 16
    • 0034601180 scopus 로고    scopus 로고
    • Jaskari T, Vuorio M, Kontturi K, et al. Controlled transdermal iontophoresis by ion-exchange fiber. J Control Release 2000; 67 2-3, 179-90
    • Jaskari T, Vuorio M, Kontturi K, et al. Controlled transdermal iontophoresis by ion-exchange fiber. J Control Release 2000; 67 (2-3): 179-90
  • 17
    • 0031662033 scopus 로고    scopus 로고
    • Development and in vivo assessment of a transdermal system for physostigmine
    • Benech H, Vincenti M, Fouchart F, et al. Development and in vivo assessment of a transdermal system for physostigmine. Methods Find Exp Clin Pharmacol 1998; 20 (6): 489-98
    • (1998) Methods Find Exp Clin Pharmacol , vol.20 , Issue.6 , pp. 489-498
    • Benech, H.1    Vincenti, M.2    Fouchart, F.3
  • 18
    • 0036001406 scopus 로고    scopus 로고
    • Transdermal iontophoresis of tacrine in vivo
    • Kankkunen T, Sulkava R, Vuorio M, et al. Transdermal iontophoresis of tacrine in vivo. Pharm Res 2002; 19: 705-8
    • (2002) Pharm Res , vol.19 , pp. 705-708
    • Kankkunen, T.1    Sulkava, R.2    Vuorio, M.3
  • 19
    • 0028448282 scopus 로고
    • Tacrine: A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease
    • Wagstaff AJ, McTavish D. Tacrine: a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease. Drugs Aging 1994; 4 (6): 510-40
    • (1994) Drugs Aging , vol.4 , Issue.6 , pp. 510-540
    • Wagstaff, A.J.1    McTavish, D.2
  • 20
    • 37548999377 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients
    • Lefèvre G, Sedek G, Jhee SS, et al. Pharmacokinetics and pharmacodynamics of the novel daily rivastigmine transdermal patch compared with twice-daily capsules in Alzheimer's disease patients. Clin Pharmacol Ther 2008; 83: 106-14
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 106-114
    • Lefèvre, G.1    Sedek, G.2    Jhee, S.S.3
  • 21
    • 0036349129 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors
    • Jann MW, Shirley KL, Small GW. Clinical pharmacokinetics and pharmacodynamics of cholinesterase inhibitors. Clin Pharmacokinet 2002; 41 (10): 719-39
    • (2002) Clin Pharmacokinet , vol.41 , Issue.10 , pp. 719-739
    • Jann, M.W.1    Shirley, K.L.2    Small, G.W.3
  • 22
    • 0035735272 scopus 로고    scopus 로고
    • Effects of transdermal nicotine on learning, memory, verbal fluency, concentration, and general health in a healthy sample at risk for dementia
    • Howe MN, Price IR. Effects of transdermal nicotine on learning, memory, verbal fluency, concentration, and general health in a healthy sample at risk for dementia. Int Psychogeriatr 2001; 13: 465-75
    • (2001) Int Psychogeriatr , vol.13 , pp. 465-475
    • Howe, M.N.1    Price, I.R.2
  • 23
    • 0032893921 scopus 로고    scopus 로고
    • Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease
    • White HK, Levin ED. Four-week nicotine skin patch treatment effects on cognitive performance in Alzheimer's disease. Psychopharmacology 1999; 143: 158-65
    • (1999) Psychopharmacology , vol.143 , pp. 158-165
    • White, H.K.1    Levin, E.D.2
  • 24
    • 0001388341 scopus 로고    scopus 로고
    • Nicotine effects and attention-deficit/ hyperactivity disorder
    • Piasecki M, Newhouse PA, editors, Washington, DC: American Psychiatric Press
    • Levin ED, Simon BB, Conners CK. Nicotine effects and attention-deficit/ hyperactivity disorder. In: Piasecki M, Newhouse PA, editors. Nicotine in psychiatry: psychopathology and emerging therapeutics. Washington, DC: American Psychiatric Press 2000: 203-14
    • (2000) Nicotine in psychiatry: Psychopathology and emerging therapeutics , pp. 203-214
    • Levin, E.D.1    Simon, B.B.2    Conners, C.K.3
  • 26
    • 0028086440 scopus 로고
    • Estrogen replacement therapy in older women: Comparison between Alzheimer's disease cases and nondemented control subjects
    • Henderson V, Paganini-Hill A, Emanuel C, et al. Estrogen replacement therapy in older women: comparison between Alzheimer's disease cases and nondemented control subjects. Arch Neurol 1994; 51: 896-900
    • (1994) Arch Neurol , vol.51 , pp. 896-900
    • Henderson, V.1    Paganini-Hill, A.2    Emanuel, C.3
  • 27
    • 0031899264 scopus 로고    scopus 로고
    • Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging
    • Baldereschi M, Di-Carlo A, Lepore V, et al. Estrogen-replacement therapy and Alzheimer's disease in the Italian Longitudinal Study on Aging. Neurology 1998; 50: 996-1002
    • (1998) Neurology , vol.50 , pp. 996-1002
    • Baldereschi, M.1    Di-Carlo, A.2    Lepore, V.3
  • 28
    • 17144472335 scopus 로고    scopus 로고
    • Hormone replacement therapy for cognitive function in postmenopausal women
    • CD003122
    • Hogervorst E, Yaffe K, Richards M, et al. Hormone replacement therapy for cognitive function in postmenopausal women. Cochrane Database Syst Rev 2002; (3): CD003122
    • (2002) Cochrane Database Syst Rev , Issue.3
    • Hogervorst, E.1    Yaffe, K.2    Richards, M.3
  • 29
    • 0042508791 scopus 로고    scopus 로고
    • Neuropathologic changes in Alzheimer's disease
    • Wenk GL. Neuropathologic changes in Alzheimer's disease. J Clin Psychiatry 2003; 64 Suppl. 9: 7-10
    • (2003) J Clin Psychiatry , vol.64 , Issue.SUPPL. 9 , pp. 7-10
    • Wenk, G.L.1
  • 30
    • 2942561028 scopus 로고    scopus 로고
    • The importance of neuritic plaques and tangles to the development and evolution of AD
    • Tiraboschi P, Hansen LA, Thal LJ, et al. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 2004; 62 (11): 1984-9
    • (2004) Neurology , vol.62 , Issue.11 , pp. 1984-1989
    • Tiraboschi, P.1    Hansen, L.A.2    Thal, L.J.3
  • 31
    • 0042020173 scopus 로고    scopus 로고
    • Treatment of Alzheimer's disease: Current status and new perspectives
    • Scarpini E, Scheltens P, Feldman H. Treatment of Alzheimer's disease: current status and new perspectives, Lancet Neurol 2003; 2: 539-47
    • (2003) Lancet Neurol , vol.2 , pp. 539-547
    • Scarpini, E.1    Scheltens, P.2    Feldman, H.3
  • 32
    • 33745376808 scopus 로고    scopus 로고
    • Alzheimer therapeutics: What after the cholinesterase inhibitors?
    • Walker LC, Rosen RF. Alzheimer therapeutics: what after the cholinesterase inhibitors? Age Ageing 2006; 35: 332-5
    • (2006) Age Ageing , vol.35 , pp. 332-335
    • Walker, L.C.1    Rosen, R.F.2
  • 33
    • 33846282302 scopus 로고    scopus 로고
    • The presenilin hypothesis of Alzheimer's disease: Evidence for a loss-of-function pathogenic mechanism
    • Shen J, Kelleher 3rd RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A 2007; 102 (2): 403-9
    • (2007) Proc Natl Acad Sci U S A , vol.102 , Issue.2 , pp. 403-409
    • Shen, J.1    Kelleher 3rd, R.J.2
  • 35
    • 27644583266 scopus 로고    scopus 로고
    • Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers
    • Iqbal K, Flory M, Khatoon S, et al. Subgroups of Alzheimer's disease based on cerebrospinal fluid molecular markers. Ann Neurol 2005; 58: 748-57
    • (2005) Ann Neurol , vol.58 , pp. 748-757
    • Iqbal, K.1    Flory, M.2    Khatoon, S.3
  • 36
    • 20044367108 scopus 로고    scopus 로고
    • Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms
    • Andorfer C, Acker CM, Kress Y, et al. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. J Neurosci 2005; 25: 5446-54
    • (2005) J Neurosci , vol.25 , pp. 5446-5454
    • Andorfer, C.1    Acker, C.M.2    Kress, Y.3
  • 37
    • 12144288683 scopus 로고    scopus 로고
    • Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease
    • Schmitz C, Rutten B, Pielen A, et al. Hippocampal neuron loss exceeds amyloid plaque load in a transgenic mouse model of Alzheimer's disease. Am J Pathol 2004; 164 (4): 1495-502
    • (2004) Am J Pathol , vol.164 , Issue.4 , pp. 1495-1502
    • Schmitz, C.1    Rutten, B.2    Pielen, A.3
  • 38
    • 34547756449 scopus 로고    scopus 로고
    • Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain
    • Nistor M, Don M, Parekh M, et al. Alpha- and beta-secretase activity as a function of age and beta-amyloid in Down syndrome and normal brain. Neurobiol Aging 2007; 28 (10): 1493-506
    • (2007) Neurobiol Aging , vol.28 , Issue.10 , pp. 1493-1506
    • Nistor, M.1    Don, M.2    Parekh, M.3
  • 39
    • 11444269588 scopus 로고    scopus 로고
    • Alzheimer disease and Down syndrome: Factors in pathogenesis
    • Lott I, Head E. Alzheimer disease and Down syndrome: factors in pathogenesis. Neurobiol Aging 2005; 26 (3): 383-9
    • (2005) Neurobiol Aging , vol.26 , Issue.3 , pp. 383-389
    • Lott, I.1    Head, E.2
  • 40
    • 0024990330 scopus 로고
    • Neurotropic and neurotoxic effects of amyloid beta protein: Reversal by tachykinin neuropeptides
    • Yankner B, Duffy L, Kirschner D. Neurotropic and neurotoxic effects of amyloid beta protein: reversal by tachykinin neuropeptides. Science 1990; 250: 279-82
    • (1990) Science , vol.250 , pp. 279-282
    • Yankner, B.1    Duffy, L.2    Kirschner, D.3
  • 41
    • 0033788536 scopus 로고    scopus 로고
    • Elimination of amyloid beta neurotoxicity
    • Blanchard BJ, Hiniker AE, Lu CC, et al. Elimination of amyloid beta neurotoxicity. J Alzheimers Dis 2000; 2 (2): 137-49
    • (2000) J Alzheimers Dis , vol.2 , Issue.2 , pp. 137-149
    • Blanchard, B.J.1    Hiniker, A.E.2    Lu, C.C.3
  • 42
    • 34347269184 scopus 로고    scopus 로고
    • Amyloid precursor protein and presenilin involvement in cell signaling
    • Venezia V, Nizzari M, Carlo P, et al. Amyloid precursor protein and presenilin involvement in cell signaling. Neurodegener Dis 2007; 4 (2-3): 101-11
    • (2007) Neurodegener Dis , vol.4 , Issue.2-3 , pp. 101-111
    • Venezia, V.1    Nizzari, M.2    Carlo, P.3
  • 43
    • 13744252140 scopus 로고    scopus 로고
    • A hybrid molecule that prohibits amyloid fibrils and alleviates neuronal toxicity induced by beta-amyloid (1-42)
    • Lee KH, Shin BH, Shin KJ, et al. A hybrid molecule that prohibits amyloid fibrils and alleviates neuronal toxicity induced by beta-amyloid (1-42). Biochem Biophys Res Commun 2005; 328 (4): 816-23
    • (2005) Biochem Biophys Res Commun , vol.328 , Issue.4 , pp. 816-823
    • Lee, K.H.1    Shin, B.H.2    Shin, K.J.3
  • 44
    • 20844458090 scopus 로고    scopus 로고
    • Synaptic targeting by Alzheimer's-related amyloid beta oligomers
    • Lacor PN, Buniel MC, Chang L, et al. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. J Neurosci 2004; 24 (45): 10191-200
    • (2004) J Neurosci , vol.24 , Issue.45 , pp. 10191-10200
    • Lacor, P.N.1    Buniel, M.C.2    Chang, L.3
  • 45
    • 33846949357 scopus 로고    scopus 로고
    • The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation
    • Siegel SJ, Bieschke J, Powers ET, et al. The oxidative stress metabolite 4-hydroxynonenal promotes Alzheimer protofibril formation. Biochemistry 2007; 46 (6): 1503-10
    • (2007) Biochemistry , vol.46 , Issue.6 , pp. 1503-1510
    • Siegel, S.J.1    Bieschke, J.2    Powers, E.T.3
  • 46
    • 17144391463 scopus 로고    scopus 로고
    • Diminished production of proinflammatory cytokines in patients with Alzheimer's disease
    • Richartz E, Batra A, Simon P, et al. Diminished production of proinflammatory cytokines in patients with Alzheimer's disease. Dement Geriatr Cogn Disord 2005; 19: 184-8
    • (2005) Dement Geriatr Cogn Disord , vol.19 , pp. 184-188
    • Richartz, E.1    Batra, A.2    Simon, P.3
  • 47
    • 2942755836 scopus 로고    scopus 로고
    • Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease
    • Arosio B, Trabattoni D, Galimberti L, et al. Interleukin-10 and interleukin-6 gene polymorphisms as risk factors for Alzheimer's disease. Neurobiol Aging 2004; 25: 1009-15
    • (2004) Neurobiol Aging , vol.25 , pp. 1009-1015
    • Arosio, B.1    Trabattoni, D.2    Galimberti, L.3
  • 48
    • 0035201651 scopus 로고    scopus 로고
    • Patients with Alzheimer's disease display a pro-inflammatory phenotype
    • Remarque EJ, Bollen EL, Weverling-Rijnsburger AW, et al. Patients with Alzheimer's disease display a pro-inflammatory phenotype. Exp Gerontol 2001; 36: 171-6
    • (2001) Exp Gerontol , vol.36 , pp. 171-176
    • Remarque, E.J.1    Bollen, E.L.2    Weverling-Rijnsburger, A.W.3
  • 49
    • 35048877702 scopus 로고    scopus 로고
    • Peripheral inflammatory cytokines as biomarkers in Alzheimer's disease and mild cognitive impairment
    • Guerreiro RJ, Santana I, Bras JM, et al. Peripheral inflammatory cytokines as biomarkers in Alzheimer's disease and mild cognitive impairment. Neurodegener Dis 2007; 4 (6): 406-12
    • (2007) Neurodegener Dis , vol.4 , Issue.6 , pp. 406-412
    • Guerreiro, R.J.1    Santana, I.2    Bras, J.M.3
  • 51
    • 33646144212 scopus 로고    scopus 로고
    • Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: Insights into the development of Alzheimer's disease
    • Butterfield DA, Poon HF, Clair DS, et al. Redox proteomics identification of oxidatively modified hippocampal proteins in mild cognitive impairment: insights into the development of Alzheimer's disease. Neurobiol 2006; 22: 223-32
    • (2006) Neurobiol , vol.22 , pp. 223-232
    • Butterfield, D.A.1    Poon, H.F.2    Clair, D.S.3
  • 52
    • 33644987632 scopus 로고    scopus 로고
    • Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment
    • Butterfield DA, Reed T, Perluigi M, et al. Elevated protein-bound levels of the lipid peroxidation product, 4-hydroxy-2-nonenal, in brain from persons with mild cognitive impairment. Neurosci Lett 2006; 397: 170-3
    • (2006) Neurosci Lett , vol.397 , pp. 170-173
    • Butterfield, D.A.1    Reed, T.2    Perluigi, M.3
  • 53
    • 29844450760 scopus 로고    scopus 로고
    • Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment
    • Schipper HM, Bennett DA, Liberman A, et al. Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment. Neurobiol 2006; 27: 252-61
    • (2006) Neurobiol , vol.27 , pp. 252-261
    • Schipper, H.M.1    Bennett, D.A.2    Liberman, A.3
  • 54
    • 0034661784 scopus 로고    scopus 로고
    • Cyclin' toward dementia: Cell cycle abnormalities and abortive oncogenesis in Alzheimer disease
    • Raina AK, Zhu X, Rottkamp CA, et al. Cyclin' toward dementia: cell cycle abnormalities and abortive oncogenesis in Alzheimer disease. J Neurosci Res 2000; 61 (2): 128-33
    • (2000) J Neurosci Res , vol.61 , Issue.2 , pp. 128-133
    • Raina, A.K.1    Zhu, X.2    Rottkamp, C.A.3
  • 55
    • 33947181594 scopus 로고    scopus 로고
    • Neuronal cell cycle reentry mediates Alzheimer disease-type changes
    • McShea A, Lee HG, Petersen RB, et al. Neuronal cell cycle reentry mediates Alzheimer disease-type changes. Biochim Biophys Acta 2007; 1772: 467-72
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 467-472
    • McShea, A.1    Lee, H.G.2    Petersen, R.B.3
  • 56
    • 33846051882 scopus 로고    scopus 로고
    • Mitochondrial dysfunction and Alzheimer's disease
    • Chen X, Stern D, Yan SD. Mitochondrial dysfunction and Alzheimer's disease. Curr Alzheimer Res 2006; 3 (5): 515-20
    • (2006) Curr Alzheimer Res , vol.3 , Issue.5 , pp. 515-520
    • Chen, X.1    Stern, D.2    Yan, S.D.3
  • 57
    • 34250211094 scopus 로고    scopus 로고
    • Mitochondrial Abeta: A potential cause of metabolic dysfunction in Alzheimer's disease
    • Chen X, Yan SD. Mitochondrial Abeta: a potential cause of metabolic dysfunction in Alzheimer's disease. IUBMB Life 2006; 58 (12): 686-94
    • (2006) IUBMB Life , vol.58 , Issue.12 , pp. 686-694
    • Chen, X.1    Yan, S.D.2
  • 58
    • 34648843067 scopus 로고    scopus 로고
    • Mitochondrial cascade hypothesis of Alzheimer's disease: Myth or reality?
    • Mancuso M, Coppede F, Murri L, et al. Mitochondrial cascade hypothesis of Alzheimer's disease: myth or reality? Antioxid Redox Signal 2007; 9 (10): 1631-46
    • (2007) Antioxid Redox Signal , vol.9 , Issue.10 , pp. 1631-1646
    • Mancuso, M.1    Coppede, F.2    Murri, L.3
  • 59
    • 50249142804 scopus 로고    scopus 로고
    • Alzheimer's disease [online]. Available from URL: http://en.wikipedia. org/wiki/Alzheimer's_disease [Accessed 2007 Jul 28]
    • Alzheimer's disease [online]. Available from URL: http://en.wikipedia. org/wiki/Alzheimer's_disease [Accessed 2007 Jul 28]
  • 60
    • 0033003028 scopus 로고    scopus 로고
    • Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: Results of a placebo-controlled, double-blind, pilot study
    • Asthana S, Craft S, Baker LD, et al. Cognitive and neuroendocrine response to transdermal estrogen in postmenopausal women with Alzheimer's disease: results of a placebo-controlled, double-blind, pilot study. Psychoneuroendocrinology 1999; 24 (6): 657-77
    • (1999) Psychoneuroendocrinology , vol.24 , Issue.6 , pp. 657-677
    • Asthana, S.1    Craft, S.2    Baker, L.D.3
  • 61
    • 36148976139 scopus 로고    scopus 로고
    • Rivastigmine exposure provided by a transdermal patch versus capsules
    • Dec;
    • Mercier F, Lefèvre G, Huang HL, et al. Rivastigmine exposure provided by a transdermal patch versus capsules. Curr Med Res Opin 2007 Dec; 23 (12): 3199-204
    • (2007) Curr Med Res Opin , vol.23 , Issue.12 , pp. 3199-3204
    • Mercier, F.1    Lefèvre, G.2    Huang, H.L.3
  • 62
    • 1442329832 scopus 로고    scopus 로고
    • Transdermal patches are more than skin deep
    • Morrow T. Transdermal patches are more than skin deep. Manag Care 2004; 13 (4): 50-1
    • (2004) Manag Care , vol.13 , Issue.4 , pp. 50-51
    • Morrow, T.1
  • 63
    • 24644497684 scopus 로고    scopus 로고
    • Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects
    • Greig NH, Ruckle J, Comer P, et al. Anticholinesterase and pharmacokinetic profile of phenserine in healthy elderly human subjects. Curr Alzheimer Res 2005; 2 (4): 483-92
    • (2005) Curr Alzheimer Res , vol.2 , Issue.4 , pp. 483-492
    • Greig, N.H.1    Ruckle, J.2    Comer, P.3
  • 64
    • 0028947754 scopus 로고
    • Transdermal delivery of tacrine: I. Identification of a suitable delivery vehicle
    • Sathyan G, Ritschel WA, Hussain AS. Transdermal delivery of tacrine: I. Identification of a suitable delivery vehicle. Int J Pharm 1995; 114: 75-83
    • (1995) Int J Pharm , vol.114 , pp. 75-83
    • Sathyan, G.1    Ritschel, W.A.2    Hussain, A.S.3
  • 66
    • 0034574284 scopus 로고    scopus 로고
    • The experimental Alzheimer drug phenserine: Preclinical pharmacokinetics and pharmacodynamics
    • Greig NH, De Micheli E, Holloway HW, et al. The experimental Alzheimer drug phenserine: preclinical pharmacokinetics and pharmacodynamics. Acta Neurol Scand Suppl 2000; 176: 74-84
    • (2000) Acta Neurol Scand Suppl , vol.176 , pp. 74-84
    • Greig, N.H.1    De Micheli, E.2    Holloway, H.W.3
  • 67
    • 33947375500 scopus 로고    scopus 로고
    • Pre-clinical investigation of the topical administration of phenserine: Transdermal flux cholinesterase inhibition and cognitive efficacy
    • Utsuki T, Uchimura N, Irikura M, et al. Pre-clinical investigation of the topical administration of phenserine: transdermal flux cholinesterase inhibition and cognitive efficacy. J Pharmacol Exp Ther 2007; 321 (1): 353-61
    • (2007) J Pharmacol Exp Ther , vol.321 , Issue.1 , pp. 353-361
    • Utsuki, T.1    Uchimura, N.2    Irikura, M.3
  • 68
    • 33947522151 scopus 로고    scopus 로고
    • Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: Relative effects of body site application
    • Lefèvre G, Sedek G, Huang HA, et al. Pharmacokinetics of a rivastigmine transdermal patch formulation in healthy volunteers: relative effects of body site application. J Clin Pharmacol 2007; 47: 471-8
    • (2007) J Clin Pharmacol , vol.47 , pp. 471-478
    • Lefèvre, G.1    Sedek, G.2    Huang, H.A.3
  • 69
    • 36148976139 scopus 로고    scopus 로고
    • Rivastigmine exposure provided by a transdermal patch versus capsules
    • Dec;
    • Mercier F, Lefèvre G, Huang HL, et al. Rivastigmine exposure provided by a transdermal patch versus capsules. Curr Med Res Opin 2007 Dec; 23 (12): 3199-204
    • (2007) Curr Med Res Opin , vol.23 , Issue.12 , pp. 3199-3204
    • Mercier, F.1    Lefèvre, G.2    Huang, H.L.3
  • 70
    • 34547640475 scopus 로고    scopus 로고
    • Pharmacokinetic rationale for the rivastigmine patch
    • Cummings J, Lefèvre G, Small G, et al. Pharmacokinetic rationale for the rivastigmine patch. Neurology 2007; 69: S10-3
    • (2007) Neurology , vol.69
    • Cummings, J.1    Lefèvre, G.2    Small, G.3
  • 71
    • 34249705681 scopus 로고    scopus 로고
    • Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease
    • Winblad B, Kawata AK, Beusterien KM, et al. Caregiver preference for rivastigmine patch relative to capsules for treatment of probable Alzheimer's disease. Int J Geriatr Psychiatry 2007; 22 (5): 485-91
    • (2007) Int J Geriatr Psychiatry , vol.22 , Issue.5 , pp. 485-491
    • Winblad, B.1    Kawata, A.K.2    Beusterien, K.M.3
  • 72
    • 50249090320 scopus 로고    scopus 로고
    • 2 rivastigmine patch in patients with Alzheimer's disease (ADEPT) [online]. Available from URL: http://clinicaltrials.gov/ct2/show/NCT00561392 [Accessed 2008 Jul 13]
    • 2 rivastigmine patch in patients with Alzheimer's disease (ADEPT) [online]. Available from URL: http://clinicaltrials.gov/ct2/show/NCT00561392 [Accessed 2008 Jul 13]
  • 73
    • 50249185491 scopus 로고    scopus 로고
    • 2 patch in patients with Alzheimer's disease (AD) showing cognitive decline [online]. Available from URL: http://clinicaltrials.gov/ct2/show/NCT00506415 [Accessed 2008 Jul 13]
    • 2 patch in patients with Alzheimer's disease (AD) showing cognitive decline [online]. Available from URL: http://clinicaltrials.gov/ct2/show/NCT00506415 [Accessed 2008 Jul 13]
  • 74
    • 30144438248 scopus 로고    scopus 로고
    • Transgenic mice overexpressing human beta-amyloid have functional nicotinic alpha 7 receptors
    • Spencer JP, Weil A, Hill K, et al. Transgenic mice overexpressing human beta-amyloid have functional nicotinic alpha 7 receptors. Neuroscience 2006; 137 (3): 795-805
    • (2006) Neuroscience , vol.137 , Issue.3 , pp. 795-805
    • Spencer, J.P.1    Weil, A.2    Hill, K.3
  • 75
    • 33749331275 scopus 로고    scopus 로고
    • Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice
    • Rosato SM, Cattaneo A, Cherubini E. Nicotine-induced enhancement of synaptic plasticity at CA3-CA1 synapses requires GABAergic interneurons in adult anti-NGF mice. J Physiol 2006; 576 Pt 2: 361-77
    • (2006) J Physiol , vol.576 , Issue.PART 2 , pp. 361-377
    • Rosato, S.M.1    Cattaneo, A.2    Cherubini, E.3
  • 76
    • 0029054285 scopus 로고
    • Nicotine patches in Alzheimer's disease: Pilot study on learning, memory, and safety
    • Wilson AL, Langley LK, Monley J, et al. Nicotine patches in Alzheimer's disease: pilot study on learning, memory, and safety. Pharmacol Biochem Behav 1995; 51: 509-14
    • (1995) Pharmacol Biochem Behav , vol.51 , pp. 509-514
    • Wilson, A.L.1    Langley, L.K.2    Monley, J.3
  • 77
    • 33845994435 scopus 로고    scopus 로고
    • Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors
    • Hogg RC, Bertrand D. Partial agonists as therapeutic agents at neuronal nicotinic acetylcholine receptors. Biochem Pharmacol 2007; 73 (4): 459-68
    • (2007) Biochem Pharmacol , vol.73 , Issue.4 , pp. 459-468
    • Hogg, R.C.1    Bertrand, D.2
  • 78
    • 0036672690 scopus 로고    scopus 로고
    • The utility of muscarinic agonists in the treatment of Alzheimer's disease
    • Messer Jr WS. The utility of muscarinic agonists in the treatment of Alzheimer's disease. J Mol Neurosci 2002; 19 (1-2): 187-93
    • (2002) J Mol Neurosci , vol.19 , Issue.1-2 , pp. 187-193
    • Messer Jr, W.S.1
  • 79
    • 0036676048 scopus 로고    scopus 로고
    • AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease
    • Fisher A, Brandeis R, Bar-Ner RH, et al. AF150(S) and AF267B: M1 muscarinic agonists as innovative therapies for Alzheimer's disease. J Mol Neurosci 2002; 19 (1-2): 145-53
    • (2002) J Mol Neurosci , vol.19 , Issue.1-2 , pp. 145-153
    • Fisher, A.1    Brandeis, R.2    Bar-Ner, R.H.3
  • 80
    • 0036143544 scopus 로고    scopus 로고
    • Brain proton magnetic resonance spectroscopy in Alzheimer disease: Changes after treatment with xanomeline
    • Frederick B, Satlin A, Wald LL, et al. Brain proton magnetic resonance spectroscopy in Alzheimer disease: changes after treatment with xanomeline. Am J Geriatr Psychiatry 2002; 10 (1): 81-8
    • (2002) Am J Geriatr Psychiatry , vol.10 , Issue.1 , pp. 81-88
    • Frederick, B.1    Satlin, A.2    Wald, L.L.3
  • 81
    • 0030902127 scopus 로고    scopus 로고
    • Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease
    • Bodick NC, Offen WW, Levey AI, et al. Effects of xanomeline, a selective muscarinic receptor agonist, on cognitive function and behavioral symptoms in Alzheimer disease. Arch Neurol 1997; 54 (4): 465-73
    • (1997) Arch Neurol , vol.54 , Issue.4 , pp. 465-473
    • Bodick, N.C.1    Offen, W.W.2    Levey, A.I.3
  • 82
    • 0041866256 scopus 로고    scopus 로고
    • Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists
    • Mirza NR, Peters D, Sparks RG. Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists. CNS Drug Rev 2003; 9 (2): 159-86
    • (2003) CNS Drug Rev , vol.9 , Issue.2 , pp. 159-186
    • Mirza, N.R.1    Peters, D.2    Sparks, R.G.3
  • 83
    • 0034513825 scopus 로고    scopus 로고
    • Estrogens and estrogen-like non-feminizing compounds: Their role in the prevention and treatment of Alzheimer's disease
    • Green PS, Simpkins JW. Estrogens and estrogen-like non-feminizing compounds: their role in the prevention and treatment of Alzheimer's disease. Ann N Y Acad Sci 2000; 924: 93-8
    • (2000) Ann N Y Acad Sci , vol.924 , pp. 93-98
    • Green, P.S.1    Simpkins, J.W.2
  • 84
    • 33745837467 scopus 로고    scopus 로고
    • Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life
    • Yaffe K, Vittinghoff E, Ensrud KE, et al. Effects of ultra-low-dose transdermal estradiol on cognition and health-related quality of life. Arch Neurol 2006; 63 (7): 945-50
    • (2006) Arch Neurol , vol.63 , Issue.7 , pp. 945-950
    • Yaffe, K.1    Vittinghoff, E.2    Ensrud, K.E.3
  • 85
    • 27744445643 scopus 로고    scopus 로고
    • A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and order: Effecting mood, cognition and quality of life
    • Almeida OP, Lautenschlager NT, Vasikaran S, et al. A 20-week randomized controlled trial of estradiol replacement therapy for women aged 70 years and order: effecting mood, cognition and quality of life. Neurobiol Aging 2006; 27 (1): 141-9
    • (2006) Neurobiol Aging , vol.27 , Issue.1 , pp. 141-149
    • Almeida, O.P.1    Lautenschlager, N.T.2    Vasikaran, S.3
  • 86
    • 70249121973 scopus 로고    scopus 로고
    • Hormone replacement therapy to maintain cognitive function in women with dementia
    • CD003799
    • Hogervorst E, Yaffe K, Richards M, et al. Hormone replacement therapy to maintain cognitive function in women with dementia. Cochrane Database Syst Rev 2002; (3): CD003799
    • (2002) Cochrane Database Syst Rev , Issue.3
    • Hogervorst, E.1    Yaffe, K.2    Richards, M.3
  • 88
    • 23044476080 scopus 로고    scopus 로고
    • Transdermal estrogen patches for aggressive behavior in male patients with dementia: A randomized, controlled trial
    • Hall KA, Keks NA, O'Connor DW. Transdermal estrogen patches for aggressive behavior in male patients with dementia: a randomized, controlled trial. Int Psychogeriatr 2005; 17 (2): 165-78
    • (2005) Int Psychogeriatr , vol.17 , Issue.2 , pp. 165-178
    • Hall, K.A.1    Keks, N.A.2    O'Connor, D.W.3
  • 89
    • 33745210614 scopus 로고    scopus 로고
    • Association of estrogen receptor alpha (ESR1) Pvull and Xbal polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations
    • Corbo RM, Gambina G, Ruggeri M, et al. Association of estrogen receptor alpha (ESR1) Pvull and Xbal polymorphisms with sporadic Alzheimer's disease and their effect on apolipoprotein E concentrations. Dement Geriatr Cogn Disord 2006; 22 (1): 67-72
    • (2006) Dement Geriatr Cogn Disord , vol.22 , Issue.1 , pp. 67-72
    • Corbo, R.M.1    Gambina, G.2    Ruggeri, M.3
  • 90
    • 33747412228 scopus 로고    scopus 로고
    • Association of estrogen receptor alpha gene with Alzheimer's disease: A case-control study
    • Monastero R, Cefalu AB, Camarda C, et al. Association of estrogen receptor alpha gene with Alzheimer's disease: a case-control study. J Alzheimers Dis 2006; 9 (3): 273-8
    • (2006) J Alzheimers Dis , vol.9 , Issue.3 , pp. 273-278
    • Monastero, R.1    Cefalu, A.B.2    Camarda, C.3
  • 91
    • 33745024535 scopus 로고    scopus 로고
    • Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females
    • Porrello E, Monti MC, Sinforiani E, et al. Estrogen receptor alpha and APOEepsilon4 polymorphisms interact to increase risk for sporadic AD in Italian females. Eur J Neurol 2006; 13 (6): 639-44
    • (2006) Eur J Neurol , vol.13 , Issue.6 , pp. 639-644
    • Porrello, E.1    Monti, M.C.2    Sinforiani, E.3
  • 92
    • 34249057460 scopus 로고    scopus 로고
    • Estrogen receptor 1 gene (ESR1) variants in Alzheimer's disease: Results of a meta-analysis
    • Luckhaus C, Sand PG. Estrogen receptor 1 gene (ESR1) variants in Alzheimer's disease: results of a meta-analysis. Aging Clin Exp Res 2007; 19 (2): 165-8
    • (2007) Aging Clin Exp Res , vol.19 , Issue.2 , pp. 165-168
    • Luckhaus, C.1    Sand, P.G.2
  • 93
    • 84861002891 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed 2007 Jul 29
    • Chopda G. Transdermal drug delivery systems: a review, 2006 [online]. Available from URL: http://www.pharmainfo.net/exclusive/reviews/ transdermal_drug_delivery_systems_:_a_review/ [Accessed 2007 Jul 29]
    • (2006) Transdermal drug delivery systems: A review
    • Chopda, G.1
  • 94
    • 0036910592 scopus 로고    scopus 로고
    • Optimization of treatment by applying programmable rate-controlled drug delivery technology
    • Chien YW, Lin S. Optimization of treatment by applying programmable rate-controlled drug delivery technology. Clin Pharmacokinet 2002; 41 (15): 1267-99
    • (2002) Clin Pharmacokinet , vol.41 , Issue.15 , pp. 1267-1299
    • Chien, Y.W.1    Lin, S.2
  • 95
    • 32544459171 scopus 로고    scopus 로고
    • Transdermal rivastigmine treatment does not worsen impaired performance of complex motions in patients with Alzheimer's disease
    • Muhlack S, Przuntek H, Miller T. Transdermal rivastigmine treatment does not worsen impaired performance of complex motions in patients with Alzheimer's disease. Pharmacopsychiatry 2006; 39: 16-9
    • (2006) Pharmacopsychiatry , vol.39 , pp. 16-19
    • Muhlack, S.1    Przuntek, H.2    Miller, T.3
  • 96
    • 34547641018 scopus 로고    scopus 로고
    • A transdermal patch in Alzheimer disease
    • Cummings J. A transdermal patch in Alzheimer disease. Neurology 2007; 69 Suppl. 1: S2-3
    • (2007) Neurology , vol.69 , Issue.SUPPL. 1
    • Cummings, J.1
  • 97
    • 0036263563 scopus 로고    scopus 로고
    • Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats
    • Lemaire L, Fournier J, Ponthus C, et al. Magnetic resonance imaging of the neuroprotective effect of xaliproden in rats. Invest Radiol 2002; 37 (6): 321-7
    • (2002) Invest Radiol , vol.37 , Issue.6 , pp. 321-327
    • Lemaire, L.1    Fournier, J.2    Ponthus, C.3
  • 98
    • 35748977086 scopus 로고    scopus 로고
    • Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau
    • Epub Sep 6
    • Santa-Maria I, Hernández F, Del Rio J, et al. Tramiprosate, a drug of potential interest for the treatment of Alzheimer's disease, promotes an abnormal aggregation of tau. Mol Neurodegener 2007; 2: 17. Epub 2007 Sep 6
    • (2007) Mol Neurodegener 2007 , vol.2 , pp. 17
    • Santa-Maria, I.1    Hernández, F.2    Del Rio, J.3
  • 100
    • 35548940796 scopus 로고    scopus 로고
    • online, Available from URL:, Accessed 2008 Jul 13
    • Hone J. Alzheimer's disease: the facts [online]. Available from URL: http://www.pharmatimes.com/subscribe [Accessed 2008 Jul 13]
    • Alzheimer's disease: The facts
    • Hone, J.1
  • 101
    • 20444413826 scopus 로고    scopus 로고
    • Transdermal iontophoresis: Combination strategies to improve transdermal iontophoretic drug delivery
    • Wang Y, Thakur R, Fan Q, et al. Transdermal iontophoresis: combination strategies to improve transdermal iontophoretic drug delivery. Eur J Pharm Biopharm 2005; 60: 179-91
    • (2005) Eur J Pharm Biopharm , vol.60 , pp. 179-191
    • Wang, Y.1    Thakur, R.2    Fan, Q.3


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