In vitro study on polyethylene glycol-chitosan copolymer as a gene delivery vector

Yaoxue Xuebao

Volumn 43, Issue 8, 2008, Pages 848-854

  Zhang, Wei ^a   Pan, Shi Rong ^a   Zhang, Xuan ^a   Luo, Xin ^a   Wang, Chi ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

Chitosan; Gene delivery; Nanoparticle; Polyethylene glycol

Indexed keywords

CHITOSAN; DRUG CARRIER; MACROGOL DERIVATIVE; MONOMETHOXYPOLYETHYLENE GLYCOL; NANOPARTICLE; POLYMER;

ADENOCARCINOMA; ARTICLE; CHEMISTRY; GENE VECTOR; GENETIC TRANSFECTION; HELA CELL; HUMAN; LUNG TUMOR; PARTICLE SIZE; PATHOLOGY; PLASMID; TUMOR CELL LINE;

ADENOCARCINOMA; CELL LINE, TUMOR; CHITOSAN; DRUG CARRIERS; GENETIC VECTORS; HELA CELLS; HUMANS; LUNG NEOPLASMS; NANOPARTICLES; PARTICLE SIZE; PLASMIDS; POLYETHYLENE GLYCOLS; POLYMERS; TRANSFECTION;

EID: 50249100446     PISSN: 05134870     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (26)

1. Lee KY, Kwon IC, Kim YH, et al. Preparation of chitosan self-aggregates as a gene delivery system [J]. J Control Release, 1998,51:213-220.
2. Zhang W, Pan SR. Application of chitosan in novel drug delivery systems [J]. Prog Pharm Sci, 2005,29:404-409.
3. Erbacher P, Zou S, Bettinger T, et al. Chitosan-based vector/DNA complexes for gene delivery: biophysical characteristics and transfection ability [J]. Pharm Res, 1998,15:1332-1339.
4. Maclaughlin FC, Mumper RJ, Wang J, et al. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery [J]. J Control Release, 1998,56:259-272.
5. Richardson SC, Kolbe HV, Duncan R. Potential of low molecular mass chitosan as a DNA delivery system: biocompatibility, body distribution and ability to complex and protect DNA [J]. Int J Pharm, 1999,178:231-243.
6. Köping-Höggård M, Tubulekas I, Guan H, et al. Chitosan as a nonviral gene delivery system. Structure-property relationships and characteristics compared with polyethylenimine in vitro and after lung administration in vivo [J]. Gene Ther, 2001,8:1108-1121.
7. Bozkir A, Saka OM. Chitosan nanoparticles for plasmid DNA delivery: effect of chitosan molecular structure on formulation and release characteristics [J]. Drug Deliv, 2004,11:107-112.
8. Bozkir A, Saka OM. Chitosan-DNA nanoparticles: effect on DNA integrity, bacterial transformation and transfection efficiency [J]. J Drug Target, 2004,12:281-288.
9. Yang XR, Zong L, Yuan XY. Chitosan nanoparticles as gene vector: effect of particle size on transfection efficiency [J]. Acta Pharm Sin, 2007,42:774-779.
10. Moghimia SM, Szebenib J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties [J]. Prog Lipid Res, 2003,42:463-478.
11. Gref R, Lück M, Quellec P, et al. 'Stealth' corona-core nanoparticles surface modified by polyethylene glycol (PEG): influences of the corona (PEG chain length and surface density) and of the core composition on phagocytic uptake and plasma protein adsorption [J]. Colloids Surf B Biointerfaces, 2000,18:301-313.
12. Peracchia MT, Harnisch S, Pinto-Alphandary H, et al. Visualization of in vitro protein-rejecting properties of PEGylated stealth polycyanoacrylate nanoparticles [J]. Biomaterials, 1999,20:1269-1275.
13. Zhao W, Ma HL, Qi XR. Cationic liposomes loaded with doxorubicin targeting to the tumor neovasculature in vitro [J]. Acta Pharm Sin, 2007,42:982-988.
14. Luca LD, Glacemeili G, Porcheddu A. A very mild and chemoselective oxidation of alcohols to carbonyl compounds [J]. Org Lett, 2001,3:3041-3043.
15. Lee MK, Chun SK, Choi WJ, et al. The use of chitosan as a condensing agent to enhance emulsion-mediated gene transfer [J]. Biomaterials, 2005,26:2147-2156.
16. Jiang X, Dai H, Leong KW, et al. Chitosan-g-PEG/DNA complexes deliver gene to the rat liver via intrabiliary and intraportal infusions [J]. J Gene Med, 2006,8:477-487.
17. Hu FQ, Zhao MD, Yuan H, et al. A novel chitosan oligosaccharide-stearic acid micelles for gene delivery; properties and in vitro transfection studies [J]. Int J Pharm, 2006,315:158-166.
18. Ping Y, Ma Q, Chen JH. Dextran-spermine polycation as a vector for gene transfection in vitro [J]. Acta Pharm Sin, 2007,42:669-674.
19. Bhattarai N, Ramay HR, Gunn J, et al. PEG-grafted chitosan as an injectable thermosensitive hydrogel for sustained protein release [J]. J Control Release, 2005, 103:609-624.
20. Bhattrarai N, Matsen FA, Zhang M. PEG-grafted chitosan as an injectable thermoreversible hydrogel [J]. Macromol Biosci, 2005,5:107-111.
21. Lin AH, Liu YM, Ping QN. Free amino groups on the surface of chitosan nanoparticles and its characteristics [J]. Acta Pharm Sin, 2007,42:323-328.
22. Kiang T, Wen J, Lim HW, et al. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection [J]. Biomaterials, 2004,25:5293-5301.
23. Sato T, Ishii T, Okahata Y. In vitro gene delivery mediated by chitosan. Effect of pH, serum, and molecular mass of chitosan on the transfection efficiency [J]. Biomaterials, 2001,22:2075-2080.
24. Danielsen S, Varum KM, Stokke BT. Structural analysis of chitosan mediated DNA condensation by AFM: influence of chitosan molecular parameters [J]. Biomacromolecules, 2004,5:928-936.
25. Lavertu M, Methot S, Tran-Khanh N, et al. High efficiency gene transfer using chitosan/DNA nanoparticles with specific combination of molecular weight and degree of deacetylation [J]. Biomaterials, 2006,27:4815-4824.
26. Strand SP, Danielsen S, Christensen BE, et al. Influence of chitosan structure on the formation and stability of DNA-chitosan polyelectrolyte complexes [J]. Biomacromolecules, 2005,6:3357-3366.