Evaluation of the CD14 C-159 T polymorphism in the German Multicenter Allergy Study cohort

Clinical and Experimental Allergy

Volumn 33, Issue 2, 2003, Pages 166-169

  Sengler, C ^a   Haider, A ^a   Sommerfeld, C ^a   Lau, S ^a   Baldini, M ^b   Martinez, F ^b   Wahn, U ^a   Nickel, Renate ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

Author keywords

Atopy; CD14; Genetics; IgE

Indexed keywords

CD14 ANTIGEN; CYTOKINE; GENOMIC DNA; IMMUNOGLOBULIN E; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5;

ALLERGIC RHINITIS; ALLERGY; ARTICLE; ASTHMA; ATOPIC DERMATITIS; ATOPY; CHILD; CLINICAL TRIAL; COHORT ANALYSIS; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DISEASE ASSOCIATION; GENE FREQUENCY; GENOTYPE; GERMANY; HUMAN; INFANT; INTERVIEW; LUNG FUNCTION TEST; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PHENOTYPE; PHYSICAL EXAMINATION; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROVOCATION TEST; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIGENS, CD14; FOLLOW-UP STUDIES; GENOTYPE; HUMANS; HYPERSENSITIVITY, IMMEDIATE; IMMUNOGLOBULIN E; INFANT, NEWBORN; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 0037326378     PISSN: 09547894     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2222.2003.01549.x     Document Type: Article

References (13)

1. Sengler C, Lau S, Wahn U, Nickel R. Interactions between genes and environmental factors in asthma and atopy: new developments. Respir Res 2002; 3:7.
2. von Mutius E, Braun-Fahrlander C, Schierl R et al. Exposure to endotoxin or other bacterial components might protect against the development of atopy. Clin Exp Allergy 2000; 30:1230-4.
3. Ulevitch RJ, Tobias PS. Receptor-dependent mechanisms of cell stimulation by bacterial endotoxin. Annu Rev Immunol 1995; 13:437-57.
4. Verhasselt V, Buelens C, Willems F, De Groote D, Haeffner-Cavaillon N, Goldman M. Bacterial lipopolysaccharide stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: evidence for a soluble CD14-dependent pathway. J Immunol 1997; 158:2919-25.
5. Baldini M, Lohman IC, Halonen M, Erickson RP, Holt PG, Martinez FD. A polymorphism* in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E. Am J Respir Cell Mol Biol 1999; 20:976-83.
6. LeVan TD, Bloom JW, Bailey TJ et al. A common single nucleotide polymorphism in the CD14 promoter decreases the affinity of Sp protein binding and enhances transcriptional activity. J Immunol 2001; 167:5838-44.
7. Koppelman GH, Reijmerink NE, Colin Stine O et al. Association of a promoter polymorphism of the CD14 gene and atopy. Am J Respir Crit Care Med 2001; 163:965-9.
8. Kulig M, Klettke U, Wahn V, Forster J, Bauer CP, Wahn U. Development of seasonal allergic rhinitis during the first 7 years of life. J Allergy Clin Immunol 2000; 106:832-9.
9. Lau S, Illi S, Sommerfeld C et al. Early exposure to house-dust mite and cat allergens and development of childhood asthma: a cohort study. Multicentre Allergy Study Group. Lancet 2000; 356:1392-7.
10. Bergmann RL, Edenharter G, Bergmann KE et al. Atopic dermatitis in early infancy predicts allergic airway disease at 5 years. Clin Exp Allergy 1998; 28:965-70.
11. Nickel R, Wahn U, Hizawa N et al. Evidence for linkage of chromosome 12q15-q24.1 markers to high total serum IgE concentrations in children of the German Multicenter Allergy Study. Genomics 1997; 46:159-62.
12. Illi S, von Mutius E, Lau S et al. Early childhood infectious diseases and the development of asthma up to school age: a birth cohort study. BMJ 2001; 322:390-5.
13. Vercelli D, Baldini M, Martinez F. The monocyte/IgE connection: may polymorphisms in the CD14 gene teach us about IgE regulation? Int Arch Allergy Immunol 2001; 124:20-4.