The monocyte/IgE connection: May polymorphisms in the CD14 gene teach us about IgE regulation?

International Archives of Allergy and Immunology

Volumn 124, Issue 1-3, 2001, Pages 20-24

  Vercelli, Donata ^a,b   Baldini, Mauro ^a   Martinez, Fernando ^a  

^a UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF ARIZONA   (United States)

Author keywords

CD14; IgE; IL 4; Monocytes; Polymorphism, genetic

Indexed keywords

CD14 ANTIGEN; IMMUNOGLOBULIN E; INTERLEUKIN 4; LIGAND; LIPOPOLYSACCHARIDE; MONOCLONAL ANTIBODY;

ASTHMA; BRONCHUS HYPERREACTIVITY; CHROMOSOME 5Q; CONFERENCE PAPER; CONTROLLED STUDY; GENE LOCUS; GENETIC POLYMORPHISM; HUMAN; IMMUNE RESPONSE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOGLOBULIN PRODUCTION; IMMUNOREGULATION; MONONUCLEAR CELL; PRIORITY JOURNAL; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM;

ANTIGENS, CD14; CELLS, CULTURED; DRUG SYNERGISM; GENOTYPE; HUMANS; IMMUNOGLOBULIN E; INTERLEUKIN-4; LIPOPOLYSACCHARIDES; MODELS, IMMUNOLOGICAL; MONOCYTES; POLYMORPHISM, GENETIC;

EID: 0035053503     PISSN: 10182438     EISSN: None     Source Type: Journal    
DOI: 10.1159/000053658     Document Type: Conference Paper

References (16)

1. Genetics of asthma and inflammation: The status
2. A polymorphism in the 5′ flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum IgE
3. Recognition of gram-negative bacteria and endotoxin by the innate immune system
4. Engagement of CD14 on monocytes inhibits the synthesis of human immunoglobulins, including IgE
5. Endogenous IL-6 plays an obligatory role in IL-4 induced human IgE synthesis
6. Innate immunity: The virtues of a monoclonal system of recognition
7. Phylogenetic perspectives in innate immunity
8. CD14 is a pattern recognition receptor
9. Lipopolysaccharide-binding proteins is required to combat a murine gram-negative bacterial infection
10. Targeted deletion of the lipopolysaccharide (LPS)-binding protein gene leads to profound suppression of LPS responses ex vivo, whereas in vivo responses remain intact
11. Reduced risk of hay fever and asthma among children of farmers
12. Inflammatory response to acute inhalation of endotoxin in asthmatic patients
13. Modification of the inflammatory response to allergen challenge after exposure to bacterial lipopolysaccharide
14. Interleukin 4 down-regulates the expression of CD14 in normal human monocytes
15. IL-13 downregulates CD14 expression and TNF-αsecretion in human monocytes