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Volumn 17, Issue 6, 2006, Pages 635-642

The role of neurotrophins and insulin on tau pathology in Alzheimer's disease

Author keywords

Alzheimer's disease; BDNF; Insulin; Neurotrophins; Phosphorylation; Tau

Indexed keywords

INSULIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN; TAU PROTEIN;

EID: 33846432364     PISSN: 03341763     EISSN: None     Source Type: Journal    
DOI: 10.1515/REVNEURO.2006.17.6.635     Document Type: Review
Times cited : (24)

References (50)
  • 1
    • 0028227962 scopus 로고
    • Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease
    • Alonso AC, Zaidi T, Grundke-Iqbal I, Iqbal K. Role of abnormally phosphorylated tau in the breakdown of microtubules in Alzheimer disease. Proc Natl Acad Sci USA 1994; 91: 5562-5566.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 5562-5566
    • Alonso, A.C.1    Zaidi, T.2    Grundke-Iqbal, I.3    Iqbal, K.4
  • 2
    • 21344463770 scopus 로고    scopus 로고
    • Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation
    • Babu JR, Geetha T, Wooten MW. Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. J Neurochem 2005; 94: 192-203.
    • (2005) J Neurochem , vol.94 , pp. 192-203
    • Babu, J.R.1    Geetha, T.2    Wooten, M.W.3
  • 5
    • 3042558276 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3: A drug target for CNS therapies
    • Bhat RV, Budd Haeberlein SL, Avila J. Glycogen synthase kinase 3: a drug target for CNS therapies. J Neurochem 2004; 89: 1313-1317.
    • (2004) J Neurochem , vol.89 , pp. 1313-1317
    • Bhat, R.V.1    Budd Haeberlein, S.L.2    Avila, J.3
  • 6
    • 0027338266 scopus 로고
    • Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: Distinction between PHF-like immunoreactivity and microtubule binding
    • Biernat J, Gustke N, Drewes G, Mandelkow EM, Mandelkow E. Phosphorylation of Ser262 strongly reduces binding of tau to microtubules: distinction between PHF-like immunoreactivity and microtubule binding. Neuron 1993; 11: 153-163.
    • (1993) Neuron , vol.11 , pp. 153-163
    • Biernat, J.1    Gustke, N.2    Drewes, G.3    Mandelkow, E.M.4    Mandelkow, E.5
  • 8
    • 0031148892 scopus 로고    scopus 로고
    • Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease
    • Boissiere F, Faucheux B, Ruberg M, Agid Y, Hirsch EC. Decreased TrkA gene expression in cholinergic neurons of the striatum and basal forebrain of patients with Alzheimer's disease. Exp Neurol 1997; 145: 245-252.
    • (1997) Exp Neurol , vol.145 , pp. 245-252
    • Boissiere, F.1    Faucheux, B.2    Ruberg, M.3    Agid, Y.4    Hirsch, E.C.5
  • 10
  • 11
    • 0027197191 scopus 로고
    • Detection of NGF-like activity in human brain tissue: Increased levels in Alzheimer's disease
    • Crutcher KA, Scott SA, Liang S, Everson WV, Weingartner J. Detection of NGF-like activity in human brain tissue: increased levels in Alzheimer's disease. J Neurosci 1993; 13: 2540-2550.
    • (1993) J Neurosci , vol.13 , pp. 2540-2550
    • Crutcher, K.A.1    Scott, S.A.2    Liang, S.3    Everson, W.V.4    Weingartner, J.5
  • 12
    • 25844490528 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 kinase signalling mechanism
    • Elliott E, Atlas R, Lange A, Ginzburg I. Brain-derived neurotrophic factor induces a rapid dephosphorylation of tau protein through a PI-3 kinase signalling mechanism. Eur J Neurosci 2005; 22: 1081-1089.
    • (2005) Eur J Neurosci , vol.22 , pp. 1081-1089
    • Elliott, E.1    Atlas, R.2    Lange, A.3    Ginzburg, I.4
  • 13
    • 0037111833 scopus 로고    scopus 로고
    • Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
    • Path T, Eidenmuller J, Brandt R. Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J Neurosci 2002; 22: 9733-9741.
    • (2002) J Neurosci , vol.22 , pp. 9733-9741
    • Path, T.1    Eidenmuller, J.2    Brandt, R.3
  • 17
    • 0036723891 scopus 로고    scopus 로고
    • A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex
    • Garzon D, Yu G, Fahnestock M. A new brain-derived neurotrophic factor transcript and decrease in brain-derived neurotrophic factor transcripts 1, 2 and 3 in Alzheimer's disease parietal cortex. J Neurochem 2002; 82: 1058-1064.
    • (2002) J Neurochem , vol.82 , pp. 1058-1064
    • Garzon, D.1    Yu, G.2    Fahnestock, M.3
  • 18
    • 11144258263 scopus 로고    scopus 로고
    • Mutations causing neurodegenerative tauopathies
    • Goedert M, Jakes R. Mutations causing neurodegenerative tauopathies. Biochim Biophys Acta 2005; 1739: 240-250.
    • (2005) Biochim Biophys Acta , vol.1739 , pp. 240-250
    • Goedert, M.1    Jakes, R.2
  • 21
    • 0030748390 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons
    • Hong M, Lee VM. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J Biol Chem 1997; 272: 19547-19553.
    • (1997) J Biol Chem , vol.272 , pp. 19547-19553
    • Hong, M.1    Lee, V.M.2
  • 22
    • 1842785179 scopus 로고    scopus 로고
    • Glucose metabolism and insulin receptor signal transduction in Alzheimer disease
    • Hoyer S. Glucose metabolism and insulin receptor signal transduction in Alzheimer disease. Eur J Pharmacol 2004; 490: 115-125.
    • (2004) Eur J Pharmacol , vol.490 , pp. 115-125
    • Hoyer, S.1
  • 23
    • 0033302335 scopus 로고    scopus 로고
    • Tau protein in normal and Alzheimer's disease brain
    • Johnson GV, Jenkins SM. Tau protein in normal and Alzheimer's disease brain. J Alzheimers Dis 1999; 1: 307-328.
    • (1999) J Alzheimers Dis , vol.1 , pp. 307-328
    • Johnson, G.V.1    Jenkins, S.M.2
  • 24
    • 0028351190 scopus 로고
    • Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development
    • Jones KR, Farinas I, Backus C, Reichardt LF. Targeted disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell 1994; 76: 989-999.
    • (1994) Cell , vol.76 , pp. 989-999
    • Jones, K.R.1    Farinas, I.2    Backus, C.3    Reichardt, L.F.4
  • 25
    • 10944273982 scopus 로고    scopus 로고
    • Phosphorylated tau and the neurodegenerative foldopathies
    • Kosik KS, Shimura H. Phosphorylated tau and the neurodegenerative foldopathies. Biochim Biophys Acta 2005; 1739: 298-310.
    • (2005) Biochim Biophys Acta , vol.1739 , pp. 298-310
    • Kosik, K.S.1    Shimura, H.2
  • 26
    • 0035134990 scopus 로고    scopus 로고
    • Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 2001; 6: 83-86.
    • Kunugi H, Ueki A, Otsuka M, Isse K, Hirasawa H, Kato N, Nabika T, Kobayashi S, Nanko S. A novel polymorphism of the brain-derived neurotrophic factor (BDNF) gene associated with late-onset Alzheimer's disease. Mol Psychiatry 2001; 6: 83-86.
  • 27
    • 0029133373 scopus 로고
    • Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain
    • Ledesma MD, Bonay P, Avila J. Tau protein from Alzheimer's disease patients is glycated at its tubulin-binding domain. J Neurochem 1995; 65: 1658-1664.
    • (1995) J Neurochem , vol.65 , pp. 1658-1664
    • Ledesma, M.D.1    Bonay, P.2    Avila, J.3
  • 28
    • 0028065142 scopus 로고
    • Analysis of microtubule- associated protein tau glycation in paired helical filaments
    • Ledesma MD, Bonay P, Colaco C, Avila J. Analysis of microtubule- associated protein tau glycation in paired helical filaments. J Biol Chem 1994; 269: 21614-21619.
    • (1994) J Biol Chem , vol.269 , pp. 21614-21619
    • Ledesma, M.D.1    Bonay, P.2    Colaco, C.3    Avila, J.4
  • 29
    • 0034638270 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons
    • Lesort M, Johnson GV. Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons. Neuroscience 2000; 99: 305-316.
    • (2000) Neuroscience , vol.99 , pp. 305-316
    • Lesort, M.1    Johnson, G.V.2
  • 30
    • 0345276565 scopus 로고    scopus 로고
    • Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses
    • Mandelkow EM, Stamer K, Vogel R, Thies E, Mandelkow E, Clogging of axons by tau, inhibition of axonal traffic and starvation of synapses. Neurobiol Aging 2003; 24: 1079-1085.
    • (2003) Neurobiol Aging , vol.24 , pp. 1079-1085
    • Mandelkow, E.M.1    Stamer, K.2    Vogel, R.3    Thies, E.4    Mandelkow, E.5
  • 32
    • 0035239020 scopus 로고    scopus 로고
    • Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease
    • Murer MG, Yan Q, Raisman-Vozari R. Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease. Prog Neurobiol 2001; 63: 71-124.
    • (2001) Prog Neurobiol , vol.63 , pp. 71-124
    • Murer, M.G.1    Yan, Q.2    Raisman-Vozari, R.3
  • 34
    • 19344362136 scopus 로고    scopus 로고
    • Olin D, MacMurray J, Comings DE. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci Lett 2005; 381: 275-278.
    • Olin D, MacMurray J, Comings DE. Risk of late-onset Alzheimer's disease associated with BDNF C270T polymorphism. Neurosci Lett 2005; 381: 275-278.
  • 35
    • 0035369840 scopus 로고    scopus 로고
    • Trk receptors: Mediators of neurotrophin action
    • Patapoutian A, Reiehardt LF. Trk receptors: mediators of neurotrophin action. Curr Opin Neurobiol 2001; 11: 272-280.
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 272-280
    • Patapoutian, A.1    Reiehardt, L.F.2
  • 36
    • 20744434559 scopus 로고    scopus 로고
    • Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
    • Peng S, Wuu J, Mufson EJ, Fahnestock M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J Neurochem 2005; 93: 1412-1421.
    • (2005) J Neurochem , vol.93 , pp. 1412-1421
    • Peng, S.1    Wuu, J.2    Mufson, E.J.3    Fahnestock, M.4
  • 39
    • 0036371793 scopus 로고    scopus 로고
    • A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the apolipoprotein E ε4 allele
    • Riemenschneider M, Schwarz S, Wagenpfeil S, Diehl J, Muller U, Forstl H, Kurz A. A polymorphism of the brain-derived neurotrophic factor (BDNF) is associated with Alzheimer's disease in patients lacking the apolipoprotein E ε4 allele. Mol Psychiatry 2002; 7: 782-785.
    • (2002) Mol Psychiatry , vol.7 , pp. 782-785
    • Riemenschneider, M.1    Schwarz, S.2    Wagenpfeil, S.3    Diehl, J.4    Muller, U.5    Forstl, H.6    Kurz, A.7
  • 40
    • 0029933181 scopus 로고    scopus 로고
    • Identification of a tau promoter region mediating tissue-specific-regulated expression in PC 12 cells
    • Sadot F. Heicklen-Klein A, Barg J, Lazarovici P, Ginzburg I. Identification of a tau promoter region mediating tissue-specific-regulated expression in PC 12 cells. J Mol Biol 1996; 256: 805-812.
    • (1996) J Mol Biol , vol.256 , pp. 805-812
    • Sadot, F.1    Heicklen-Klein, A.2    Barg, J.3    Lazarovici, P.4    Ginzburg, I.5
  • 41
    • 23044481208 scopus 로고    scopus 로고
    • The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse
    • Schechter R, Beju D, Miller KE. The effect of insulin deficiency on tau and neurofilament in the insulin knockout mouse. Biochem Biophys Res Commun 2005; 334: 979-986.
    • (2005) Biochem Biophys Res Commun , vol.334 , pp. 979-986
    • Schechter, R.1    Beju, D.2    Miller, K.E.3
  • 43
    • 0029022112 scopus 로고
    • Nerve growth factor in Alzheimer's disease: Increased levels throughout the brain coupled with declines in nucleus basalis
    • Scott SA, Mufson EJ, Weingartner JA, Skau KA, Crutcher KA. Nerve growth factor in Alzheimer's disease: increased levels throughout the brain coupled with declines in nucleus basalis. J Neurosci 1995; 15: 6213-6221.
    • (1995) J Neurosci , vol.15 , pp. 6213-6221
    • Scott, S.A.1    Mufson, E.J.2    Weingartner, J.A.3    Skau, K.A.4    Crutcher, K.A.5
  • 44
    • 0035888286 scopus 로고    scopus 로고
    • Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells
    • Shelton SB, Johnson GV. Tau and HMW tau phosphorylation and compartmentalization in apoptotic neuronal PC12 cells. J Neurosci Res 2001; 66: 203-213.
    • (2001) J Neurosci Res , vol.66 , pp. 203-213
    • Shelton, S.B.1    Johnson, G.V.2
  • 45
    • 1042266624 scopus 로고    scopus 로고
    • CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
    • Shimura H, Schwartz D, Gygi SP, Kosik KS. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem 2004; 279: 4869-4876.
    • (2004) J Biol Chem , vol.279 , pp. 4869-4876
    • Shimura, H.1    Schwartz, D.2    Gygi, S.P.3    Kosik, K.S.4
  • 46
    • 0033813571 scopus 로고    scopus 로고
    • Neurotrophic factors in Alzheimer's and Parkinson's disease brain
    • Siegel GJ, Chauhan NB. Neurotrophic factors in Alzheimer's and Parkinson's disease brain. Brain Res Brain Res Rev 2000; 33: 199-227.
    • (2000) Brain Res Brain Res Rev , vol.33 , pp. 199-227
    • Siegel, G.J.1    Chauhan, N.B.2
  • 47
    • 3342908640 scopus 로고    scopus 로고
    • Beta-amyloid peptide at sublethal concentrations down-regulates brain-derived neurotrophic factor functions in cultured cortical neurons
    • Tong L, Balazs R, Thornton PL, Cotman CW. Beta-amyloid peptide at sublethal concentrations down-regulates brain-derived neurotrophic factor functions in cultured cortical neurons. J Neurosci 2004; 24: 6799-6809.
    • (2004) J Neurosci , vol.24 , pp. 6799-6809
    • Tong, L.1    Balazs, R.2    Thornton, P.L.3    Cotman, C.W.4
  • 48
    • 1642578180 scopus 로고    scopus 로고
    • Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset
    • Tsai SJ, Hong CJ, Liu HC, Liu TY, Hsu LE, Lin CH. Association analysis of brain-derived neurotrophic factor Val66Met polymorphisms with Alzheimer's disease and age of onset Neuropsychobiology 2004; 49: 10-12.
    • (2004) Neuropsychobiology , vol.49 , pp. 10-12
    • Tsai, S.J.1    Hong, C.J.2    Liu, H.C.3    Liu, T.Y.4    Hsu, L.E.5    Lin, C.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.