Production of a high value-added soybean containing bioactive mevinolins and isoflavones

Journal of Food Science and Nutrition

Volumn 12, Issue 1, 2007, Pages 29-34

  Pyo, Young Hee ^a  

^a Korea Food Research Institute   (South Korea)

Author keywords

Hypocholesterolemic agent; Isoflavones; Medicinal food; Mevinolin; Monascus fermented soybean

Indexed keywords

GLYCINE MAX; MONASCUS; MONASCUS PILOSUS;

EID: 49649122852     PISSN: 1226332X     EISSN: None     Source Type: Journal    
DOI: 10.3746/jfn.2007.12.1.029     Document Type: Article

References (29)

1. Buckland B, Gbewonyo K, Hallada T, Kaplan L, Masurekar P. 1989. Novel microbial products for medicine and agriculture. Elsevier, Amsterdam. p 161-169.
2. Juzlova P, Martinkova L, Kren V. 1996. Secondary metabolitesof the fungus Monascus: a review. J Indus Microbiol 16:163-170.
3. Goldstein JL, Brown MS. 1984. Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol. J Lipid Res 25:1450-1461.
4. Manzoni M, Rollini M. 2002. Biosynthesis and biotechnological production of statins by filamentous fungi and application of these cholesterol-lowering drugs. Appl Microbiol Biotechnol 58:555-564.
5. Friedrich J, Zuzek M, Bencina M, Cimerman A, Strancar A, Radez I. 1995. High performance liquid chromatographic analysis of mevinolin as mevinolinic acid in fermentation broths. J Chromatogr A 704:363-367.
6. Li YG, Zhang F, Wang ZT, Hu ZB. 2004. Identification and chemical profiling of monacolins in red yeast rice using high-performance liquid chromatography with photodiode array detector and mass spectrometry. J Pharmaceut Biomed 35:1101-1112.
7. Lai LST, Tsai TH, Wang TC, Cheng TY. 2005. The influence of culturing environments on lovastatin production by Aspergillus terreus in submerged cultures. Enzyme Microb Tech 36:737-748.
8. Endo A, Hasumi K, Negishi S. 1985. Monacolins J and L new inhibitors of cholesterol biosynthesis produced by Monascus ruber. J Antibiotechnol 38:420-422.
9. Novak N, Gerdin S, Berovic M. 1997. Increased lovastatin formation by Aspergillus terreus using repeated fed-batch process. Biotechnol Lett 19:947-948.
10. Pandy A, Soccol CR, Mitchell D. 2000. New developments in solid state fermentation: I-bioprocesses and products. Process Biochem 35:1153-1169.
11. Casas López JL, Sánchez Pérez JA, Fernández Sevilla JM. 2003. Production of lovastatin by Aspergillus terreus: effectsof the C: N ratio and the principal nutrientsongrowth and metabolite production. Enzyme Microb Tech 33:270-277.
12. Kim MS, Lee YS. 2005. Effects of soy isoflavone and/or estrogen treatments on bone metabolism in ovariectomized rats. J Med Food 8:439-445.
13. Potter SM, Baum JA, Teng RJ, Stillman NF, Shay JW, Erdman Jr. 1998. Soy protein and isoflavones: their effects on blood lipids and bone density in postmenopausal women. Am J Clin Nutr 68:1375S-1379S.
14. De Kleijin MJ, van der Schouw YT, Wilson PW. 2002. Dietary intake of phytoestrogens is associated with a favorable metabolic cardiovascular risk profile in post-menopausal U. S. women: the Framingham study. J Nutr 132:276-282.
15. Coward L, Barnes NC, Setchell KDR, Barnes S. 1993. Genistein, daidzein, and their β-glucoside conjugates; Antitumor isoflavones in soybean foods from American and Asian diets. J Agric Food Chem 41:1961-1967.
16. Shin JI, Lee MS, Park OJ. 2005. Effects of soyisoflavonoid on molecular markers related to apoptosis in mature and ovariectomized female rats, and mammalian tumor cell lines. Food Sci Biotechnol 14:709-714.
17. Messina M, Hughes C. 2003. Efficacy of soyfoods and soybean isoflavone supplements for alleviating menopausal symptoms is positively related to initial hot flush frequency. J Med Food 6:1-11.
18. Xu X, Keecha SH, Wang HJ, Murphy PA, Hendrich S. 1995. Bioavailability of soybean isoflavones depends upon gut microflora in women. J Nutr 125:2307-2315.
19. Setchell KDR, Brown MN, Zimmer-Nechemias L, Wolfe BE, Brashear WT, Kirschner AS. 2002. Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability. Am J Clin Nutr 76:447-453.
20. Day AJ, Dupont S, Ridley S, Rhodes M J C, Morgan M R A, Williamson G. 1998. Deglucosylation of flavonoid and isoflavonoids glycosides by human small intestine and liver β-glucosidase activity. FEBS Lett 436:71-75.
21. Izumi T, Piskula MK, Osawa S, Obata A, Tobe K, Saito M. 2000. Soy isoflavone aglycones are absorbed faster and in higher amounts than their glucosides in human. J Nutr 130:1695-1699.
22. Pyo YH, Lee YC. 2006. Mevinolin production by Monascus pilosus KFRI-1140 (IFO 480) in solid state fermentation using soymeal. Food Sci Biotechnol 15:647-649.
23. Pyo YH. 2006. Optimum condition for production of mevinolin from the soybean fermented with Monascus sp. Korean J Food Sci Technol 38:256-261.
24. Matsuda S, Norimoto F, Matsumoto Y, Ohba R, Teramoto Y, Ohta N, Ueda S. 1994. Solubilizationofnovel isoflavone glycoside-hydrolyzing β-glucosidase from Lactobacillus casei subsp. rhamnosus. J Ferment Bioeng 77:439-441.
25. Pyo YH, Lee TC, Lee YC. 2005. Enrichment of bioactive isoflavones in soymilk fermented with β-glucosidase-producing lactic acid bacteria. Food Res Intern 38:551-559.
26. Hendrickson L, Davis CR, Roach C, Nguyen DK, Aldrich T, McAca PC, Reeves CD. 1999. Lovastatin biosynthesis in Aspergillus terreus: characterization of blocked mutants, enzyme activities and a multifunctional polyketide synthase gene. Chem Biology 6:429-439.
27. Claudio C, Laura L. 2003. Effects of statins on lipoprotein fractions. Intern Congr Series 1253:247-252.
28. Park YK, Alencar, SM, Nery IA, Agular CL, Pacheco T A R C. 2001. Enrichment of isoflavone aglycone in extracted soybean isoflavones by heat and fungal β-glucosidase. Food Sci Biotechnol 34:14-18.
29. Tsangalis D, Ashton JE, McGill AEJ, Shah NP. 2002. Enzymic transformation of isoflavone phytoestrogens in soymilk by β-glucosidase-producing bifidobacteria. J Food Sci 67:3104-3113.