Association of Low-Level Ozone and Fine Particles with Respiratory Symptoms in Children with Asthma

JAMA

Volumn 290, Issue 14, 2003, Pages 1859-1867

  Gent, Janneane F ^a,c   Triche, Elizabeth W ^a   Holford, Theodore R ^a   Belanger, Kathleen ^a   Bracken, Michael B ^a   Beckett, William S ^b   Leaderer, Brian P ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^c YALE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRONCHODILATING AGENT; OZONE; ANTIASTHMATIC AGENT;

AIR QUALITY; ARTICLE; ASTHMA; CHILD; DRUG USE; DYSPNEA; ENVIRONMENTAL EXPOSURE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; PARTICULATE MATTER; PRIORITY JOURNAL; RISK FACTOR; THORAX PAIN; UNITED KINGDOM; WHEEZING; ABNORMAL RESPIRATORY SOUND; AIR POLLUTANT; AIR POLLUTION; CHEMICALLY INDUCED DISORDER; COHORT ANALYSIS; FEMALE; HOSPITALIZATION; MALE; PARTICLE SIZE; PATHOPHYSIOLOGY; PRESCHOOL CHILD; UNITED STATES;

AIR POLLUTANTS; AIR POLLUTION; ANTI-ASTHMATIC AGENTS; ASTHMA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; CONNECTICUT; DYSPNEA; FEMALE; HUMANS; MALE; MASSACHUSETTS; OZONE; PARTICLE SIZE; RESPIRATORY SOUNDS; SEVERITY OF ILLNESS INDEX;

EID: 0141957222     PISSN: 00987484     EISSN: None     Source Type: Journal    
DOI: 10.1001/jama.290.14.1859     Document Type: Article

References (24)

1. Gold DR, Damokosh Al, Pope CA III, et al. Particulate and ozone pollutant effects on the respiratory function of children in southwest Mexico City. Epidemiology. 1999;10:8-16.
2. Romieu I, Meneses F, Ruiz S, et al. Effects of air pollution on the respiratory health of asthmatic children living in Mexico City. Am J Respir Crit Care Med. 1996;154:300-307.
3. Romieu I, Meneses F, Ruiz S, et al. Effects of intermittent ozone exposure on peak expiratory flow and respiratory symptoms among asthmatic children in Mexico City. Arch Environ Health. 1997;52:368-376.
4. Peters A, Dockery DW, Heinrich J, Wichmann HE. Medication use modifies the health effects of particulate sulfate air pollution in children with asthma. Environ Health Perspect. 1997;105:430-435.
5. Ostro BD, Lipsett MJ, Mann JK, Braxton-Owens H, White MC. Air pollution and asthma exacerbations among African-American children in Los Angeles. Inhal Toxicol. 1995;7:711-722.
6. Ostro B, Lipsett M, Mann J, Braxton-Owens H, White M. Air pollution and exacerbation of asthma in African-American children in Los Angeles. Epidemiology. 2001;12:200-208.
7. Mortimer KM, Tager IB, Dockery DW, Neas LM, Redline S. The effect of ozone on inner-city children with asthma: identification of susceptible subgroups. Am J Respir Crit Care Med. 2000;162:1838-1845.
8. Delfino RJ, Zeiger RS, Seltzer JM, Street DH. Symptoms in pediatric asthmatics and air pollution: differences in effects by symptom severity, anti-inflammatory medication use and particulate averaging time. Environ Health Perspect. 1998;106:751-761.
9. Gielen MH, van der Zee SC, van Wijnen JH, van Steen CJ. Acute effects of summer air pollution on respiratory health of asthmatic children. Am J Respir Crit Care Med. 1997;155:2105-2108.
10. Thurston GD, Lippmann M, Scott MB, Fine JM. Summertime haze air pollution and children with asthma. Am J Respir Crit Care Med. 1997;155:654-660.
11. Gent JF, Ren P, Belanger K, et al. Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environ Health Perspect. 2002;110:A781-A786.
12. Belanger K, Beckett W, Triche E, et al. Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. Am J Epidemiol. 2003;158:195-202.
13. US Environmental Protection Agency. Air Quality Criteria for Ozone and Related Photochemical Oxidants. Research Triangle Park, NC: Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office; 1996. EPA report EPA/600/AP-93/004a-c.
14. State of Connecticut Department of Environmental Protection. Annual Air Quality Summary (1999). Available at: http://dep.state.ct.us/air2/ozone/99aqs .pdf. Accessed November 18, 2002.
15. Commonwealth of Massachusetts Department of Environmental Protection. Air Quality Report (2000). Available at: http://www.mass.gov/dep/bwp/daqc. Accessed November 18, 2002.
16. SAS Version 8. Cary, NC: SAS Institute Inc; 2001.
17. Liang K-Y, Zeger SL. Longitudinal data analysis using generalized linear models. Biometrika. 1986;73:13-22.
18. Allison PD. Logistic Regression Using the SAS System: Theory and Application. Cary, NC: SAS Institute Inc; 1999.
19. Silverman F. Asthma and respiratory irritants (ozone). Environ Health Perspect. 1979;29:131-136.
20. Hanania NA, Tarlo SM, Silverman F, Urch B, Senathirajah N, Zamel N, Corey P. Effect of exposure to low levels of ozone on the response to inhaled allergen in allergic asthmatic patients. Chest. 1998;114:752-756.
21. Kehrl HR, Peden DB, Ball B, Folinsbee LJ, Horstman D. Increased specific airway reactvity of persons with mild allergic asthma after 7.6 hours of exposure to 0.16 ppm ozone. J Allergy Clin Immunol. 1999;104:1198-1199.
22. Spektor DM, Lippmann M, Lioy PJ, et al. Effects of ambient ozone on respiratory function in active normal children. Am Rev Respir Dis. 1988;137:313-320.
23. Ulmer C, Kopp M, Ihorst G, Frischer T, Forster J, Kuehr J. Effects of ambient ozone exposures during the spring and summer of 1994 on pulmonary function of schoolchildren. Pediatr Pulmonol. 1997;23:344-353.
24. Friedman MS, Powell KE, Hutwagner L, Graham LM, Teague WG. Impact of changes in transportation and commuting behaviors during the 1996 summer Olympic Games in Atlanta on air quality and childhood asthma. JAMA. 2001;285:897-905.