Silencing of keratinocyte growth factor receptor restores 5-fluorouracil and tamoxifen efficacy on responsive cancer cells

PLoS ONE

Volumn 3, Issue 6, 2008, Pages

  Rotolo, Sabrina ^a   Ceccarelli, Simona ^a   Romano, Ferdinando ^a   Frati, Luigi ^a,b   Marchese, Cinzia ^a   Angeloni, Antonio ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b IRCCS NEUROMED   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

FLUOROURACIL; KERATINOCYTE GROWTH FACTOR RECEPTOR; MESSENGER RNA; RNA; SMALL INTERFERING RNA; TAMOXIFEN; ANTINEOPLASTIC AGENT; FIBROBLAST GROWTH FACTOR RECEPTOR 2; KERATINOCYTE GROWTH FACTOR; LIGAND; PRIMER DNA;

ARTICLE; BREAST CANCER; CANCER RESISTANCE; CELL DEATH; CELL MIGRATION; CELL STRAIN MCF 7; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFICACY; DRUG RESPONSE; GENE EXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOSIS INHIBITION; MITOSIS RATE; PROTEIN EXPRESSION; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; DRUG RESISTANCE; GENETICS; METABOLISM; NEOPLASM; NUCLEOTIDE SEQUENCE; PATHOLOGY; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DNA PRIMERS; DRUG RESISTANCE, NEOPLASM; FIBROBLAST GROWTH FACTOR 7; FLUOROURACIL; GENE SILENCING; HUMANS; LIGANDS; NEOPLASMS; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TAMOXIFEN;

EID: 49649098196     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0002528     Document Type: Article

References (51)

1. Miki T, Bottaro DP, Fleming TP, Smith CL, Burgess WH, et al. (1992) Determination of ligand binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A 89: 246-250.
2. Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, et al. (1993) Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol 158: 475-486.
3. Finch PW, Rubin JS, Miki T, Ron D, Aaronson SA (1989) Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 245: 752-755.
4. Eswarakumar VP, Lax I, Schlessinger J (2005) Cellular signaling by fibroblast growth factor receptors. Cytokine Growth Factor Rev 16: 139-149.
5. Marchese C, Rubin JS, Ron D, Faggioni A, Torrisi MR, et al. (1990) Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol 144: 326-333.
6. Hines MD, Allen-Hoffman BL (1996) Keratinocyte growth factor inhibits cross-linked envelope formation and nucleosomal fragmentation in cultured human keratinocytes. J Biol Chem 271: 6245-6251.
7. Lu Y, Pan ZZ, Devaux Y, Ray P (2003) p21-activated protein kinase 4 (PAK 4) interacts with the keratinocyte growth factor receptor and participates in keratinocyte growth factor-mediated inhibition of oxidant-induced cell death. J Biol Chem 278: 10374-10380.
8. Staiano-Coico L, Krueger JG, Rubin JS, D'limi S, Vallat VP, et al. (1993) Human keratinocyte growth factor effects in a porcin model of epidermal wound healing. J Exp Med 178: 865-878.
9. Werner S, Smola H, Liao X, Longaker MT, Krieg T, et al. (1994) The function of KGF in morphogenesis of epithelium and reepithelialization of wounds. Science 266: 819-822.
10. Marchese C, Chedid M, Dirsch OR, Csaky KG, Santanelli F, et al. (1995) Modulation of keratinocyte growth factor and its receptor in reepithelializing human skin. J Exp Med 182: 1369-1376.
11. Tsuboi R, Sato C, Kurita Y, Ron D, Rubin JS, et al. (1993) Keratinocyte growth factor (FGF-7) stimulates migration and plasminogen activator activity of normal human keratinocytes. J Invest Dermatol 101: 49-53.
12. Sato C, Tsuboi R, Shi CM, Rubin JS, Ogawa H (1995) Comparative study of hepatocyte growth factor/scatter factor and keratinocyte growth factor effects on human keratinocytes. J Invest Dermatol 104: 958-963.
13. Galiacy S, Planus E, Lepetit H, Fereol S, Laurent V, et al. (2003) Keratinocyte growth factor promotes cell motility during alveolar epithelial repair in vitro. Exp Cell Res 283: 215-229.
14. Finch PW, Rubin JS (2006) Keratinocyte growth factor expression and activity in cancer: implications for use in patients with solid tumors. J Natl Cancer Inst 98: 812-824.
15. Zang XP, Pento JT (2000) Keratinocyte growth factor-induced motility of breast cancer cells. Clin Exp Metastasis 18: 573-580.
16. Nguyen TN, Zang XP, Pento JT (2002) Keratinocyte growth factor stimulates the migration and proliferation of breast cancer cells in a culture wounding model. Pharmacol Res 46: 179-183.
17. Zang XP, Lerner MR, Dunn ST, Brackett DJ, Pento JT (2003) Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res 23: 4913-4919.
18. Shin EY, Lee BH, Yang JH, Shin KS, Lee GK, et al. (2000) Up-regulation and co-expression of fibroblast growth factor receptors in human gastric cancer. J Cancer Res Clin Oncol 126: 519-528.
19. Farrell CL, Bready JV, Rex KL, Chen JN, DiPalma CR, et al. (1998) Keratinocyte growth factor protects mice from chemotherapy and radiation-induced gastrointestinal injury and mortality. Cancer Res 58: 933-939.
20. Crescioli C, Maggi M, Luconi M, Vannelli GB, Salerno R, et al. (2002) Vitamin D3 analogue inhibits keratinocyte growth factor signaling and induces apoptosis in human prostate cancer cells. Prostate 50: 15-26.
21. Tamaru N, Hishikawa Y, Ejima K, Nagasue N, Inoue S, et al. (2004) Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer. Lab Invest 84: 1460-1471.
22. Hishikawa Y, Tamaru N, Ejima K, Hayashi T, Koji T (2004) Expression of keratinocyte growth factor and its receptor in human breast cancer: its inhibitory role in the induction of apoptosis possibly through the overexpression of Bcl-2. Arch Histol Cytol 67: 455-464.
23. Tsukioka Y, Matsumura Y, Hamaguchi T, Goto M, Muro K, et al. (2001) Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FUresistant gastric cancer: a case report. Jpn J Clin Oncol 31: 450-453.
24. Zhang L, Kharbanda S, Hanfelt J, Kern FG (1998) Both autocrine and paracrine effects of transfected acidic fibroblast growth factor are involved in the estrogen-independent and antiestrogen-resistant growth of MCF-7 breast cancer cells. Cancer Res 58: 352-361.
25. McLeskey SW, Zhang L, El-Ashry D, Trock BJ, Lopez CA, et al. (1998) Tamoxifen-resistant fibroblast growth factor-transfected MCF-7 cells are cross-resistant in vivo to the antiestrogen ICI 182,780 and two aromatase inhibitors. Clin Cancer Res 4: 697-711.
26. Chang HL, Sugimoto Y, Liu S, Ye W, Wang LS, et al. (2006) Keratinocyte growth factor (KGF) induces tamoxifen (Tam) resistance in human breast cancer MCF-7 cells. Anticancer Res 26: 1773-1784.
27. Adamo V, Iorfida M, Montalto E, Festa V, Garipoli C, et al. (2007) Overview and new strategies in metastatic breast cancer (MBC) for treatment of tamoxifen-resistant patients. Ann Oncol 18 Suppl 6: vi53-57.
28. Tschaharganeh D, Ehemann V, Nussbaum T, Schirmacher P, Breuhahn K (2007) Non-specific effects of siRNAs on tumor cells with implications on therapeutic applicability using RNA interference. Pathol Oncol Res 13: 84-90.
29. Kim DH, Behlke MA, Rose SD, Chang MS, Choi S, et al. (2005) Synthetic dsRNA Dicer substrates enhance RNAi potency and efficacy. Nat Biotechnol 23: 222-226.
30. Nagy N, Bata-Csörgo Z, Kopasz N, Szeg C, Pivarcsi A, et al. (2006) The expression of keratinocyte growth factor receptor (FGFR2-IIIb) correlates with the high proliferative rate of HaCaT keratinocytes. Exp Dermatol 15: 596-605.
31. Nurcombe V, Smart CE, Chipperfield H, Cool SM, Boilly B, et al. (2000) The proliferative and migratory activities of breast cancer cells can be differentially regulated by heparan sulfates. J Biol Chem 275: 30009-30018.
32. Grimm D, Streetz KL, Jopling CL, Storm TA, Pandey K, et al. (2006) Fatality in mice due to oversaturation of cellular microRNA/short hairpin RNA pathways. Nature 441: 537-541.
33. Cha D, O'Brien P, O'Toole EA, Woodley DT, Hudson LG (1996) Enhanced modulation of keratinocyte motility by transforming growth factor-alpha (TGF-alpha) relative to epidermal growth factor (EGF). J Invest Dermatol 106: 590-597.
34. Ceccarelli S, Cardinali G, Aspite N, Picardo M, Marchese C, et al. (2007) Cortactin involvement in the keratinocyte growth factor and fibroblast growth factor 10 promotion of migration and cortical actin assembly in human keratinocytes. Exp Cell Res 313: 1758-1777.
35. Huseby RA, Maloney TM, McGrath CM (1984) Evidence for a direct growth-stimulating effect of estradiol on human MCF-7 cells in vivo. Cancer Res 44: 2654-2659.
36. Lee YR, Park J, Yu HN, Kim JS, Youn FJ, et al. (2005) Up-regulation of PI3K/Akt signaling by 17beta-estradiol through activation of estrogen receptor-alpha, but not estrogen receptor-beta, and stimulates cell growth in breast cancer cells. Biochem Biophys Res Commun 336: 1221-1226.
37. Grose R, Dickson C (2005) Fibroblast growth factor signaling in tumorigenesis. Cytokine Growth Factor Rev 16: 179-186.
38. Matsunobu T, Ishiwata T, Yoshino M, Watanabe M, Kudo M, et al. (2006) Expression of keratinocyte growth factor receptor correlates with expansive growth and early stage of gastric cancer. Int J Oncol 28: 307-314.
39. Cho K, Ishiwata T, Uchida E, Nakazawa N, Korc M, et al. (2007) Enhanced expression of keratinocyte growth factor and its receptor correlates with venous invasion in pancreatic cancer. Am J Pathol 170: 1964-1974.
40. Carstens RP, Eaton JV, Krigman HR, Walther PJ, Garcia-Blanco MA (1997) Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene 15: 3059-3065.
41. Zhang Y, Wang H, Toratani S, Sato JD, Kan M, et al. (2001) Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis. Proc Natl Acad Sci U S A 98: 11336-11340.
42. Koos RD, Banks PK, Inkster SE, Yue W, Brodie AM (1993) Detection of aromatase and keratinocyte growth factor expression in breast tumors using reverse cranscription-polymerase chain reaction. J Steroid Biochem Mol Biol 45: 217-225.
43. Bansal GS, Cox HC, Marsh S, Gomm JJ, Yiangou C, et al. (1997) Expression of keratinocyte growth factor and its receptor in human breast cancer. Br J Cancer 75: 1567-1574.
44. Liu N, Furukawa T, Kobari M, Tsao MS (1998) Comparative phenotypic studies of duct epithelial cell lines derived from normal human pancreas and pancreatic carcinoma. Am J Pathol 153: 263-269.
45. Lotti LV, Rotolo S, Francescangeli F, Frati L, Torrisi MR, et al. (2007) AKT and MAPK signaling in KGF-treated and UVB-exposed human epidermal cells. J Cell Physiol 212: 633-642.
46. Easton DF, Pooley KA, Dunning AM, Pharoah PD, Thompson D, et al. (2007) Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447: 1087-1093.
47. Hunter DJ, Kraft P, Jacobs KB, Cox DG, Yeager M, et al. (2007) A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat Genet 39: 870-874.
48. Panici PB, Bellati F, Boni T, Francescangeli F, Frati L, et al. (2007) Vaginoplasty using autologous in vitro cultured vaginal tissue in a patient with Mayer-von-Rokitansky-Kuster-Hauser syndrome. Hum Reprod 22: 2025-2028.
49. Tuschl T, Zamore PD, Lehmann R, Bartel DP, Sharp PA (1999) Targeted mRNA degradation by double-stranded RNA in vitro. Genes Dev 13: 3191-3197.
50. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29: e45.
51. Gillies RJ, Didier N, Denton M (1986) Determination of cell number in monolayer cultures. Anal Biochem 159: 109-113.