Estrogen receptor-associated expression of keratinocyte growth factor and its possible role in the inhibition of apoptosis in human breast cancer

Laboratory Investigation

Volumn 84, Issue 11, 2004, Pages 1460-1471

  Tamaru, Naóe ^a,b   Hishikawa, Yoshitaka ^a   Ejima, Kuniaki ^a   Nagasue, Naofumi ^c   Inoue, Satoshi ^d   Muramatsu, Masami ^d   Hayashi, Tomayoshi ^b   Koji, Takehiko ^a  

^a NAGASAKI UNIVERSITY GRADUATE SCHOOL OF BIOMEDICAL SCIENCES   (Japan)

^b NAGASAKI UNIVERSITY HOSPITAL   (Japan)

^c SHIMANE UNIVERSITY   (Japan)

^d SAITAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Apoptosis; Breast cancer; Estrogen receptor; Immunohistochemistry; In situ hybridization; Keratinocyte growth factor; TUNEL staining

Indexed keywords

ANTINEOPLASTIC AGENT; CYCLOPHOSPHAMIDE; ESTROGEN; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FLUOROURACIL; GROWTH FACTOR; HOE 33342; KERATINOCYTE GROWTH FACTOR; KERATINOCYTE GROWTH FACTOR RECEPTOR; KI 67 ANTIGEN; MESSENGER RNA; STEROID HORMONE;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG MECHANISM; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN VITRO STUDY; IN VIVO STUDY; MITOGENESIS; MOLECULAR MECHANICS; NICK END LABELING; OLIGONUCLEOTIDE PROBE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STROMA;

ADENOCARCINOMA; APOPTOSIS; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CARCINOMA, LOBULAR; CELL LINE, TUMOR; CYCLOPHOSPHAMIDE; DRUG COMBINATIONS; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FIBROBLAST GROWTH FACTOR 7; FIBROBLAST GROWTH FACTORS; FLUOROURACIL; HUMANS; IMMUNOENZYME TECHNIQUES; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; MIDDLE AGED; RECEPTOR, FIBROBLAST GROWTH FACTOR, TYPE 2; RECEPTORS, FIBROBLAST GROWTH FACTOR; RNA, MESSENGER;

EID: 8344282689     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700166     Document Type: Article

References (52)

1. Henderson BE, Ross R, Bernstein L. Estrogens as a cause of human cancer: the Richard and Hinda Rosenthal Foundation award lecture. Cancer Res 1988;48:246-253.
2. Katzenellenbogen BS, Kendra KL, Norman MJ, et al. Proliferation, hormonal responsiveness, and estrogen receptor content of MCF-7 human breast cancer cells grown in the short-term and long-term absence of estrogens. Cancer Res 1987;47:4355-4360.
3. Osborne CK, Hobbs K, Clark GM. Effect of estrogens and antiestrogens on growth of human breast cancer cells in athymic nude mice. Cancer Res 1985;45: 584-590.
4. Beato M. Gene regulation by steroid hormones. Cell 1989;56:335-344.
5. Paech K, Webb P, Kuiper G, et al. Differential ligand activation of estrogen receptors ER α and ER β at AP-1 sites. Science 1997;277:1508-1510.
6. Fuqua SA, Schiff R, Parra I, et al. Estrogen receptor beta protein in human breast cancer: correlation with clinical tumor parameters. Cancer Res 2003;63: 2434-2439.
7. Jarvinen T, Pelto-Huikko M, Holli K, et al. Estrogen receptor β is coexpressed with ER α and PR and associated with nodal status, grade, and proliferation rate in breast cancer. Am J Pathol 2000;156:29-35.
8. Speirs V, Malone C, Walton DS, et al. Increased expression of estrogen receptor β mRNA in tamoxifen-resistant breast cancer patients. Cancer Res 1999;59: 5421-5424.
9. Bates SE, Davidson NE, Valverius EM, et al. Expression of transforming growth factor-α and its messenger ribonucleic acid in human breast cancer: its regulation by estrogen and its possible functional significance. Mol Endocrinol 1988;2:543-555.
10. El-Ashry D, Chrysogelos S, Lippman ME, et al. Estrogen induction of TGF-α is mediated by an estrogen response element composed of two imperfect palindromes. J Steroid Biochem Mol Biol 1996;59: 261-269.
11. Hynes NE, Stern DF. The biology of erbB-2/neu/HER-2 and its role in cancer. Biochem Biophys Acta 1994; 1198:165-184.
12. Read LD, Keith Jr D, Slamon DJ, et al. Hormonal mudulation of HER-2/neu protooncogene messenger ribonucleic acid and p185 protein expression in human breast cancer cell lines. Cancer Res 1990; 50:3947-3951.
13. Russel KS, Hung MC. Transcriptional repression of the neu protooncogene by estrogen stimulated estrogen receptor. Cancer Res 1992;52:6624-6629.
14. Rubin JS, Osada H, Finch PW, et al. Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci USA 1989;86:802-806.
15. Finch PW, Rubin JS, Miki T, et al. Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science 1989;245:752-755.
16. Miki T, Bottaro DP, Fleming TP, et al. Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci USA 1992;89:246-250.
17. Yan G, Fukabori Y, Nikolaropoulos S, et al. Heparin-binding keratinocyte growth factor is a candidate stromal to epithelial cell andromedin. Mol Endocrinol 1992;6:2123-2128.
18. Koji T, Chedid M, Rubin JS, et al. Progesterone-dependent expression of keratinocyte growth factor mRNA in stromal cells of the primate endometrium: keratinocyte growth factor as a progestomedin. J Cell Biol 1994;125:393-401.
19. Bansal GS, Cox HC, Marsh S, et al. Expression of keratinocyte growth factor and its receptor in human breast cancer. Br J Cancer 1996;75:1567-1574.
20. Zhang Y, Sugimoto Y, Kulp SK, et al. Estrogen-induced keratinocyte growth factor mRNA expression in normal and cancerous human breast cells. Oncol Rep 1998;5:577-583.
21. 3 analogue inhibits keratinocyte growth factor signaling and induces apoptosis in human prostate cancer cells. Prostate 2002;50:15-26.
22. Hines MD, Allen-Hoffman BL. Keratinocyte growth factor inhibits cross-linked envelope formation and nucleosomal fragmentation in cultured human keratinocytes. J Biol Chem 1996;271:6245-6251.
23. Wildhaber BE, Yang H, Teitelbaum DH. Keratinocyte growth factor decreases total parenteral nutrition-induced apoptosis in mouse intestinal epithelium via bcl-2. J Pediatr Surg 2003;38:92-96.
24. Marchese C, Rubin J, Ron D, et al. Human keratinocyte growth factor activity on proliferation and differentiation of human keratinocytes: differentiation response distinguishes KGF from EGF family. J Cell Physiol 1990;144:326-332.
25. Marchese C, Sorice M, Stefano C, et al. Modulation of keratinocyte growth factor receptor expression in human cultured keratinocytes. Cell Growth Differ 1997;8:989-997.
26. Yamayoshi T, Nagayasu T, Matsumoto K, et al. Expression of keratinocyte growth factor/fibroblast growth factor-7 and its receptor in human lung cancer: correlation with tumor proliferative activity and patient prognosis. J Pathol 2004, in press.
27. Hovey RC, Davey HW, Vonderhaar BK, et al. Paracrine action of keratinocyte growth factor (KGF) during ruminant mammogenesis. Mol Cell Endocrinol 2001; 181:47-56.
28. Yoshii A, Koji T, Ohsawa N, et al. In situ localization of ribosomal RNAs is a reliable reference for hybridizable RNA in tissue sections. J Histochem Cytochem 1995; 43:321-328.
29. Yamamoto-Fukuda T, Aoki D, Hishikawa Y, et al. Possible involvement of keratinocyte growth factor and its receptor in enhanced epithelial-cell proliferation and acquired recurrence of middle-ear cholesteatoma. Lab Invest 2003;123:123-136.
30. Nishihara E, Nagayama Y, Inoue S, et al. Ontogenic changes in the expression of estrogen receptor α and β in rat pituitary gland detected by immunohistochemistry. Endocrinology 2000;141:615-620.
31. Tsurusaki T, Aoki D, Kanetake H, et al. Zone-dependent expression of estrogen receptor α and β in human benign prostatic hyperplasia. J Clin Endocrinol Metab 2003;88:1333-1340.
32. Hakuno N, Koji T, Yano T, et al. Fas/APO-1/CD95 system as a mediator of granulosa cell apoptosis in ovarian follicle atresia. Endocrinology 1996;137: 1938-1948.
33. Graham Jr RC, Karnovsky MJ. The early stages of absorption of injected horseradish peroxidase in the proximal tubules of mouse kidney: ultrastructural cytochemistry by a new technique. J Histochem Cytochem 1965;14:291-302.
34. Adams JC. Heavy metal intensification of DAB-based HRP reaction product. Histochem Cytochem 1981; 29:775.
35. Elias JM. A rapid, sensitive myeloperoxidase stain using 4-chloro-1 naphthol. Am J Clin Pathol 1980; 73:797-799.
36. Koji T, Nakane PK. Recent advances in molecular histochemical techniques: in situ hybridization and southwestern histochemistry. J Electron Microsc 1996; 45:119-127.
37. Hishikawa Y, Koji T, Dhar DK, et al. Metallothionein expression correlates with metastatic and proliferative potential in squamous cell carcinoma of the oesophagus. Br J Cancer 1999;81:712-720.
38. Koji T, Brenner RM. Localization of estrogen receptor messenger ribonucleic acid in rhesus monkey uterus by nonradioactive in situ hybridization with digoxigenin-labeled oligodeoxynucleotides. Endocrinology 1993;132:382-392.
39. Gavrieli Y, Sherman Y, Ben-Sasson SA. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. J Cell Biol 1992;119:493-501.
40. Schulte EK, Lyon HO, Hoyer PE. Simultaneous quantification of DNA and RNA in tissue sections. A comparative analysis of the methyl green-pyronin technique with the gallocyanin chromalum and Feulgen procedures using image cytometry. Histochem J 1992;24:305-310.
41. Zang X, Learner ML, Brackett DJ, et al. KGF-induced gene expression in MCF-7 cells using cDNA expression arrays. Breast Cancer Res Treat 2000;64:110.
42. Zang XP, Lerner MR, Dunn ST, et al. Antisense KGFR oligonucleotide inhibition of KGF-induced motility in breast cancer cells. Anticancer Res 2003;23:4913-4919.
43. Parrott JA, Kim G, Mosher R, et al. Expression and action of keratinocyte growth factor (KGF) in normal ovarian surface epithelium and ovarian cancer. Mol Cell Endocrinol 2000;167:77-87.
44. Pedchenko VK, Imagawa W. Estrogen treatment in vivo increases keratinocyte growth factor expression in the mammary gland. J Endocrinol 2000;165:39-49.
45. El-Tanani MKK, Green CD. Two separate mechanisms for ligand-independent activation of the estrogen receptor. Mol Endocrinol 1997;11:928-937.
46. Aronica SM, Katzenellenbogen BS. Stimulation of estrogen receptor-mediated transcription and alteration in the phosphorylation state of the rat uterine estrogen receptor by estrogen, cyclic adenosine monophosphate, and insulin-like growth factor-I. Mol Endocrinol 1993;7:743-752.
47. Finch PW, Lengel C, Chedid M. Cloning and characterization of the promoter region of the human keratinocyte growth factor gene. J Biol Chem 1995; 270:11230-11237.
48. Lipponen P, Aaltomaa S, Kosma VM, et al. Apoptosis in breast cancer as related to histopathological characteristics and prognosis. Eur J Cancer 1994;30A: 2068-2073.
49. Vakkala M, Lahteenmaki K, Raunio H, et al. Apoptosis during breast carcinoma progression. Clin Cancer Res 1999;5:319-324.
50. Tanaka Y, Sakamoto A, Yan Z, et al. Molecular diagnosis of human salivary gland tumors by differential expression of fibroblast growth factor receptor genes. Tiss Cult Res Commun 1997;16: 207-213.
51. Zhang Y, Wang H, Toratani S, et al. Growth inhibition by keratinocyte growth factor receptor of human salivary adenocarcinoma cells through induction of differentiation and apoptosis. Proc Natl Acad Sci USA 2001;98:11336-11340.
52. Carstens RP, Eaton JV, Krigman HR, et al. Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. Oncogene 1997; 15:3059-3065.