Restoration of susceptibility of methicillin-resistant Staphylococcus aureus to β-lactam antibiotics by acidic pH: Role of penicillin-binding protein PBP

Journal of Biological Chemistry

Volumn 283, Issue 19, 2008, Pages 12769-12776

  Lemaire, Sandrine ^a   Fuda, Cosimo ^b   Van Bambeke, Françoise ^a   Tulkens, Paul M ^a   Mobashery, Shahriar ^b  

^a UNIVERSITÉ CATHOLIQUE DE LOUVAIN   (Belgium)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; AMIDES; ANTIBIOTICS; ANTIGEN-ANTIBODY REACTIONS; BACTERIOLOGY; BINDING SITES; CIRCULAR DICHROISM SPECTROSCOPY; DICHROISM; DISSOCIATION; OPTICAL PROPERTIES; PROBABILITY DENSITY FUNCTION; RATE CONSTANTS;

ACIDIC ENVIRONMENTS; ACIDIC PH; ACTIVE SITES; BINDING PROTEINS; BIOLOGICAL PROCESSES; CIRCULAR DICHROISMS; CONFORMATIONAL CHANGES; DISSOCIATION CONSTANTS; ENZYME FORMATIONS; FIRST ORDERS; HYDROLYTIC DEACYLATION; METHICILLIN; PHYSIOLOGICAL FUNCTIONS; RESISTANT STAPHYLOCOCCUS AUREUS; S. AUREUS; TRANSPEPTIDASE;

PH EFFECTS;

BETA LACTAM ANTIBIOTIC; BOCILLIN FL; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN DERIVATIVE; PENICILLIN G; PENICILLIN V; TRITIUM; UNCLASSIFIED DRUG; ACID; ANTIINFECTIVE AGENT; BETA LACTAM; PENICILLIN BINDING PROTEIN;

ACIDITY; ACYLATION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; BACTERIUM CULTURE; CIRCULAR DICHROISM; CONTROLLED STUDY; CULTURE MEDIUM; DEACETYLATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ISOTOPE LABELING; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; NONHUMAN; PH; PHAGOCYTOSIS; PHAGOLYSOSOME; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN PURIFICATION; SPECTROSCOPY; STAPHYLOCOCCUS AUREUS; DRUG EFFECT; GENETICS; KINETICS; METABOLISM; MICROBIAL VIABILITY; PENICILLIN RESISTANCE; PROTEIN BINDING;

METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS AUREUS;

ACIDS; ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CIRCULAR DICHROISM; HYDROGEN-ION CONCENTRATION; KINETICS; METHICILLIN RESISTANCE; MICROBIAL VIABILITY; PENICILLIN-BINDING PROTEINS; PROTEIN BINDING; STAPHYLOCOCCUS AUREUS;

EID: 45149119170     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M800079200     Document Type: Article

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