Identification and phenotypic characterization of a β-lactam- dependent, methicillin-resistant Staphylococcus aureus strain

Antimicrobial Agents and Chemotherapy

Volumn 51, Issue 7, 2007, Pages 2514-2522

  Goldstein, Fred ^b   Perutka, Jiri ^a   Cuirolo, Arabela ^a   Plata, Konrad ^a,c   Faccone, Diego ^a   Morris, Joanne ^a   Sournia, Aude ^b   Kitzis, Marie Dominique ^b   Ly, Aicha ^b   Archer, Gordon ^a   Rosato, Adriana E ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b SAINT JOSEPH HOSPITAL   (France)

^c UNIVERSITY OF GDA SK   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

AMOXICILLIN; AMOXICILLIN PLUS CLAVULANIC ACID; BETA LACTAM DERIVATIVE; CEFOXITIN; CEFTOBIPROLE; CLOXACILLIN; GAMMA GLUTAMYLTRANSFERASE; GLYCOSYLTRANSFERASE; IMIPENEM; OXACILLIN; PENICILLIN BINDING PROTEIN 2A; PENICILLIN G;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERIUM IDENTIFICATION; ENZYME ACTIVITY; GENE EXPRESSION; GENE IDENTIFICATION; GENE INDUCTION; MECA GENE; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MICROARRAY ANALYSIS; NONHUMAN; OPERON; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STRAIN IDENTIFICATION;

AMINO ACID SEQUENCE; ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAMS; CEPHALOSPORINS; CHROMOSOMES, BACTERIAL; DNA, BACTERIAL; ELECTROPHORESIS, GEL, PULSED-FIELD; GENE EXPRESSION REGULATION, BACTERIAL; METHICILLIN RESISTANCE; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SELECTION (GENETICS); SEQUENCE ANALYSIS, DNA; SEQUENCE HOMOLOGY, AMINO ACID; STAPHYLOCOCCUS AUREUS; TRANSCRIPTION, GENETIC;

EID: 34447281484     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.00040-07     Document Type: Article

References (41)

1. Archer, G. L., and J. M. Bosilevac. 2001. Signaling antibiotic resistance in staphylococci. Science 291:1915-1916.
2. Archer, G. L., D. M. Niemeyer, J. A. Thanassi, and M. J. Pucci. 1994. Dissemination among staphylococci of DNA sequences associated with methicillin resistance. Antimicrob. Agents Chemother. 38:447-454.
3. Archer, G. L., J. A. Thanassi, D. M. Niemeyer, and M. J. Pucci. 1996. Characterization of IS1272, an insertion sequence-like element from Staphylococcus haemolyticus. Antimicrob. Agents Chemother. 40:924-929.
4. Bannerman, T. L., G. A. Hancock, F. C. Tenover, and J. M. Miller. 1995. Pulsed-field gel electrophoresis as a replacement for bacteriophage typing of Staphylococcus aureus. J. Clin. Microbiol. 33:551-555.
5. Berger-Bachi, B., and S. Rohrer. 2002. Factors influencing methicillin resistance in staphylococci. Arch. Microbiol. 178:165-171.
6. Boyle-Vavra, S., S. Yin, M. Challapalli, and R. S. Daum. 2003. Transcriptional induction of the penicillin-binding protein 2 gene in Staphylococcus aureus by cell wall-active antibiotics oxacillin and vancomycin. Antimicrob. Agents Chemother. 47:1028-1036.
7. Boyle-Vavra, S., S. Yin, and R. S. Daum. 2006. The VraS/VraR two-component regulatory system required for oxacillin resistance in community-acquired methicillin-resistant Staphylococcus aureus. FEMS Microbiol. Lett. 262:163-171.
8. Bozdogan, B., D. Esel, C. Whitener, F. A. Browne, and P. C. Appelbaum. 2003. Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center. J. Antimicrob. Chemother. 52:864-868.
9. Chambers, H. F. 1995. In vitro and in vivo antistaphylococcal activities of L-695,256, a carbapenem with high affinity for the penicillin-binding protein PBP 2a. Antimicrob. Agents Chemother. 39:462-466.
10. Clarke, S. R., and K. G. Dyke. 2001. Studies of the operator region of the Staphylococcus aureus beta-lactamase operon. J. Antimicrob. Chemother. 47:377-389.
11. Cohen, S., and H. M. Sweeney. 1968. Constitutive penicillinase formation in Staphylococcus aureus owing to a mutation unlinked to the penicillinase plasmid. J. Bacteriol. 95:1368-1374.
12. Comite de l'Antibiogramme de la Societe Francaise. 2003. Comite de l'Antibiogramme de la Societe Francaise de Microbiologie report. Int. J. Antimicrob. Agents 21:364-391.
13. Fung-Tomc, J. C., J. Clark, B. Minassian, M. Pucci, Y. H. Tsai, E. Gradelski, L. Lamb, I. Medina, E. Huczko, B. Kolek, S. Chaniewski, C. Ferraro, T. Washo, and D. P. Bonner. 2002. In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against methicillin-resistant and -susceptible staphylococci. Antimicrob. Agents Chemother. 46:971-976.
14. Gardete, S., S. W. Wu, S. Gill, and A. Tomasz. 2006. Role of VraSR in antibiotic resistance and antibiotic-induced stress response in Staphylococcus aureus. Antimicrob. Agents Chemother. 50:3424-3434.
15. Hartman, B. J., and A. Tomasz. 1984. Low-affinity penicillin-binding protein associated with beta-lactam resistance in Staphylococcus aureus. J. Bacteriol. 158:513-516.
16. Hebeisen, P., I. Heinze-Krauss, P. Angehrn, P. Hohl, M. G. Page, and R. L. Then. 2001. In vitro and in vivo properties of Ro 63-9141, a novel broad-spectrum cephalosporin with activity against methicillin-resistant staphylococci. Antimicrob. Agents Chemother. 45:825-836.
17. Huang, V., W. J. Brown, and M. J. Rybak. 2004. In vitro activities of a novel cephalosporin, CB-181963 (CAB-175), against methicillin-susceptible or -resistant Staphylococcus aureus and glycopeptide-intermediate susceptible staphylococci. Antimicrob. Agents Chemother. 48:2719-2723.
18. Ito, T., Y. Katayama, K. Asada, N. Mori, K. Tsutsumimoto, C. Tiensasitorn, and K. Hiramatsu. 2001. Structural comparison of three types of staphylococcal cassette chromosome mec integrated in the chromosome in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 45:1323-1336.
19. Johnson, A. P., M. Warner, M. Carter, and D. M. Livermore. 2002. In vitro activity of cephalosporin RWJ-54428 (MC-02479) against multidrug-resistant gram-positive cocci. Antimicrob. Agents Chemother. 46:321-326.
20. Kirkpatrick, B. D., S. M. Harrington, D. Smith, D. Marcellus, C. Miller, J. Dick, L. Karanfil, and T. M. Perl. 1999. An outbreak of vancomycin-dependent Enterococcus faecium in a bone marrow transplant unit. Clin. Infect. Dis. 29:1268-1273.
21. Kuroda, M., H. Kuroda, T. Oshima, F. Takeuchi, H. Mori, and K. Hiramatsu. 2003. Two-component system VraSR positively modulates the regulation of cell-wall biosynthesis pathway in Staphylococcus aureus. Mol. Microbiol. 49:807-821.
22. Matushek, M. G., M. J. Bonten, and M. K. Hayden. 1996. Rapid preparation of bacterial DNA for pulsed-field gel electrophoresis. J. Clin. Microbiol. 34:2598-2600.
23. McKinney, T. K., V. K. Sharma, W. A. Craig, and G. L. Archer. 2001. Transcription of the gene mediating methicillin resistance in Staphylococcus aureus (mecA) is corepressed but not coinduced by cognate mecA and beta-lactamase regulators. J. Bacteriol. 183:6862-6868.
24. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility test for bacteria that grow aerobically, approved standard M7-A4, 4th ed. National Committee for Clinical Laboratory Standards, Villanova, PA.
25. Okuma, K., K. Iwakawa, J. D. Turnidge, W. B. Grubb, J. M. Bell, F. G. O'Brien, G. W. Coombs, J. W. Pearman, F. C. Tenover, M. Kapi, C. Tiensasitorn, T. Ito, and K. Hiramatsu. 2002. Dissemination of new methicillin-resistant Staphylococcus aureus clones in the community. J. Clin. Microbiol. 40:4289-4294.
26. Oliveira, D. C., and H. de Lencastre. 2002. Multiplex PCR strategy for rapid identification of structural types and variants of the mec element in methicillin-resistant Staphylococcus aureus. Antimicrob. Agents Chemother. 46:2155-2161.
27. Pinho, M. G., H. de Lencastre, and A. Tomasz. 2001. An acquired and a native penicillin-binding protein cooperate in building the cell wall of drug-resistant staphylococci. Proc. Natl. Acad. Sci. USA 98:10886-10891.
28. Pinho, M. G., S. R. Filipe, H. de Lencastre, and A. Tomasz. 2001. Complementation of the essential peptidoglycan transpeptidase function of penicillin-binding protein 2 (PBP 2) by the drug resistance protein PBP 2A in Staphylococcus aureus. J. Bacteriol. 183:6525-6531.
29. Pinho, M. G., A. M. Ludovice, S. Wu, and H. de Lencastre. 1997. Massive reduction in methicillin resistance by transposon inactivation of the normal PBP2 in a methicillin-resistant strain of Staphylococcus aureus. Microb. Drug Resist. 3:409-413.
30. Rosato, A., J. Pierre, D. Billot-Klein, A. Buu-Hoi, and L. Gutmann. 1995. Inducible and constitutive expression of resistance to glycopeptides and vancomycin dependence in glycopeptide-resistant Enterococcus avium. Antimicrob. Agents Chemother. 39:830-833.
31. Rosato, A. E., W. A. Craig, and G. L. Archer. 2003. Quantitation of mecA transcription in oxacillin-resistant Staphylococcus aureus clinical isolates. J. Bacteriol. 185:3446-3452.
32. Rosato, A. E., B. N. Kreiswirth, W. A. Craig, W. Eisner, M. W. Climo, and G. L. Archer. 2003. mecA-blaZ corepressors in clinical Staphylococcus aureus isolates. Antimicrob. Agents Chemother. 47:1460-1463.
33. Sharma, V. K., C. J. Hackbarth, T. M. Dickinson, and G. L. Archer. 1998. Interaction of native and mutant MecI repressors with sequences that regulate mecA, the gene encoding penicillin binding protein 2a in methicillin-resistant staphylococci. J. Bacteriol. 180:2160-2166.
34. Sifaoui, F., and L. Gutmann. 1997. Vancomycin dependence in a vanA-producing Enterococcus avium strain with a nonsense mutation in the natural D-Ala-D-Ala ligase gene. Antimicrob. Agents Chemother. 41:1409.
35. Tenover, F. C., R. D. Arbeit, R. V. Goering, P. A. Mickelsen, B. E. Murray, D. H. Persing, and B. Swaminathan. 1995. Interpreting chromosomal DNA restriction patterns produced by pulsed-field gel electrophoresis: criteria for bacterial strain typing. J. Clin. Microbiol. 33:2233-2239.
36. Tomasz, A., S. Nachman, and H. Leaf. 1991. Stable classes of phenotypic expression in methicillin-resistant clinical isolates of staphylococci. Antimicrob. Agents Chemother. 35:124-129.
37. Van Bambeke, F., M. Chauvel, P. E. Reynolds, H. S. Fraimow, and P. Courvalin. 1999. Vancomycin-dependent Enterococcus faecalis clinical isolates and revertant mutants. Antimicrob. Agents Chemother. 43:41-47.
38. Wisplinghoff, H., A. E. Rosato, M. C. Enright, M. Noto, W. Craig, and G. L. Archer. 2003. Related clones containing SCCmec type IV predominate among clinically significant Staphylococcus epidermidis isolates. Antimicrob. Agents Chemother. 47:3574-3579.
39. Worthington, T., J. White, P. Lambert, S. Adlakha, and T. Elliott. 1999. Beta-lactam-dependent coagulase-negative staphylococcus associated with urinary-tract infection. Lancet 354:1097.
40. Yin, S., R. S. Daum, and S. Boyle-Vavra. 2006. VraSR two-component regulatory system and its role in induction of pbp2 and vraSR expression by cell wall antimicrobials in Staphylococcus aureus. Antimicrob. Agents Chemother. 50:336-343.
41. Zhang, H. Z., C. J. Hackbarth, K. M. Chansky, and H. F. Chambers. 2001. A proteolytic transmembrane signaling pathway and resistance to beta-lactams in staphylococci. Science 291:1962-1965.