The use of immortalized cell lines in GPCR screening: The good, bad and ugly

Combinatorial Chemistry and High Throughput Screening

Volumn 11, Issue 7, 2008, Pages 560-565

  Eglen, Richard M ^a   Gilchrist, Annette ^b   Reisine, Terry ^a  

^a PERKINELMER INC   (United States)

^b Caden Biosciences   (United States)

Author keywords

G protein coupled receptors; High throughput drug screening; Immortalized cells

Indexed keywords

5 METHYL 1 [[2 [(2 METHYL 3 PYRIDYL)OXY] 5 PYRIDYL]CARBAMOYL] 6 TRIFLUOROMETHYLINDOLINE; CLONIDINE; G PROTEIN COUPLED RECEPTOR; LISURIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; OXYMETAZOLINE; PHOSPHOLIPASE C; SEROTONIN 2 RECEPTOR; SEROTONIN 2A RECEPTOR; SEROTONIN 2C ANTAGONIST; SEROTONIN 4 AGONIST;

CELL ASSAY; CELL CLONING; CELL IMMORTALIZATION; CELL LINE; CELL STRAIN HEK293; CHO CELL; DRUG MECHANISM; DRUG RECEPTOR BINDING; DRUG RESEARCH; DRUG SCREENING; HIGH THROUGHPUT SCREENING; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; TARGET CELL; TUMOR CELL LINE;

ANIMALS; CELL LINE; CELL SURVIVAL; DRUG EVALUATION, PRECLINICAL; HUMANS; RECEPTORS, G-PROTEIN-COUPLED;

EID: 49449109033     PISSN: 13862073     EISSN: None     Source Type: Journal    
DOI: 10.2174/138620708785204144     Document Type: Review

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