Risk assessment of nongenotoxic carcinogens based upon cell proliferation/death rates in rodents

Risk Analysis

Volumn 16, Issue 2, 1996, Pages 221-225

  Gaylor, David W ^a   Zheng, Qi ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Carcinogens; cell proliferation; Moolgavkar Venzon Knudson model

Indexed keywords

BIOMEDICAL ENGINEERING; CALCULATIONS; CELLS; DISEASES; MATHEMATICAL MODELS; ONCOLOGY; PROBABILITY; RISK ASSESSMENT; TOXICITY;

CELL PROLIFERATION; DEATH RATES; EXTRAPOLATION; MOOLGAVKAR-VENZON-KNUDSON MODEL; NECROTIC CELLS; NO OBSERVED EFFECT LEVELS; NONGENOTOXIC CARCINOGENS; RODENTS; THRESHOLD DOSE; TUMOR INCIDENCE;

CARCINOGENS;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; CANCER RISK; CARCINOGENICITY; CELL PROLIFERATION; MORTALITY; NONHUMAN; RISK ASSESSMENT; RISK FACTOR; RISK MANAGEMENT; RODENT; TUMOR MODEL;

EID: 0030130984     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1539-6924.1996.tb01452.x     Document Type: Article

References (17)

1. S. M. Cohen and L. B. Ellwein, "Cell Proliferation in Carcinogenesis." Science 249, 1007-1011 (1990).
2. W. K. Lutz, "Dose-Response Relationship and Low Dose Extrapolation in Chemical Carcinogenesis," Carcinogenesis 11, 1243-1247 (1990).
3. S. H. Moolgavkar and D. J. Venzon, "Two Event Models for Carcinogenesis Incidence Curves for Childhood and Adult Tumors," Mathematical Biosciences 47, 55-77 (1979).
4. S. H. Moolgavkar and A. Knudson, "Mutation and Cancer: A Model for Human Carcinogenesis," Journal of the National Cancer Institute 66, 1037-1052 (1981).
5. National Research Council, Issues in Risk Assessment (National Academy Press, Washington, D.C., 1993), pp. 190-196.
6. Q. Zheng, "On the Exact Hazard and Survival Functions of the MVK Stochastic Carcinogenesis Model," Risk Analysis 14, 1081-1084 (1994).
7. A. Kopp-Schneider, C J. Portier, and C. D. Sherman, "The Exact Formula for Tumor Incidence in the Two-Stage Model," Risk Analysis 14, 1079-1080 (1994).
8. R. R. Maronpot, J. F. Foley, K. Takahashi, T. Goldsworthy, G. Clark, A. Tritscher, C. Portier, and G. Lucier, "Dose-Response for TCDD Promotion of Hepatocarcinogenesis in Rats Initiated with DEN: Histologic, Biochemical, and Cell Proliferation Endpoints," Environ. Health Perspectives 101, 634-642 (1993).
9. R. J. Kociba, D. G. Keyes, J. E. Beyer, R. M. Carreon, C. E. Wade, D A Dittenber, R. P. Kalnis, L E. Frauson, C. N. Park, S. D Barnard, R. A. Hummel, and C. G. Humiston, "Results of a Two-Year Chronic Toxicity and Oncogenicity Study of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin in Rats," Toxicol. Applied Pharmacol 46, 279-303 (1978).
10. C. Portier, A. Tritscher, M. Kohn, C. Sewall, G. Clark, L. Elder, D. Hoel, and G. Lucier, "Ligand/Receptor Binding for 2,3,7,8-TCDD: Implications for Risk Assessment," Fund. Applied Toxicol. 20, 48-56 (1993).
11. R. L. Melnick, "Does Chemically Induced Hepatocyte Proliferation Predict Liver Carcinogenesis?" Fed. Amer. Soc. Expr. Biology 6, 2698-2706 (1992).
12. J. I. Goodman, "A Rational Approach to Risk Assessment Requires the Use of Biological Information: An Analysis of the National Toxicology Program (NTP), Final Report of the Advisory Review by the NTP Board of Scientific Counselors," Regulatory Toxicol. Pharmacol. 19, 51-59 (1994)
13. K. S. Crump, "Limitations of Biological Models of Carcinogenesis for Low-Dose Extrapolation," Risk Analysis 14, 883-886 (1994).
14. C. J. Portier, "Statistical Properties of a Two-Stage Model of Carcinogenesis," Environ. Health Perspectives 76, 125-131 (1987).
15. K. S. Crump, D. G. Hoel, C. H. Langley, and R. Peto, "Fundamental Carcinogenic Processes and Their Implications for Low Dose Risk Assessment," Cancer Research 36, 2973-2979 (1976).
16. R. Peto, "Carcinogenic Effects of Chronic Exposure to Very Low Levels of Toxic Substances," Environ Health Perspectives 22, 155-161 (1978).
17. D. G. Hoel, "Incorporation of Background in Dose-Response Models," Fed. Proc. Amer. Soc. Expr. Biol. 39, 73-75 (1980).