The leptin receptor in human osteoblasts and the direct effect of leptin on bone metabolism

Gynecological Endocrinology

Volumn 19, Issue 2, 2004, Pages 97-104

  Iwamoto, I ^a   Fujino, T ^a   Douchi, T ^a  

^a KAGOSHIMA UNIVERSITY   (Japan)

Author keywords

Cell proliferation; Human osteoblast; Leptin; Leptin receptor; Real time quantitative RT PCR

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA; OSTEOCALCIN; OSTEOPONTIN; PROTEIN BAX; PROTEIN BCL 2;

APOPTOSIS; ARTICLE; ASSAY; BONE METABOLISM; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; OSTEOBLAST; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CELL DIVISION; CELLS, CULTURED; GENES, BCL-2; HUMANS; LEPTIN; OSTEOBLASTS; OSTEOCALCIN; OSTEOPONTIN; PROTO-ONCOGENE PROTEINS C-BCL-2; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIALOGLYCOPROTEINS;

EID: 4944265557     PISSN: 09513590     EISSN: None     Source Type: Journal    
DOI: 10.1080/09513590412331284389     Document Type: Article

References (28)

1. Zhang Y, Proenca R, Maffei M, et al. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32
2. Auwerx J, Staels B. Leptin. Lancet 1998;351:737-42
3. Mercer JG, Hoggard N, Williams LM, et al. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996;387:113-16
4. Nakao T, Hino M, Yamane T, et al. Expression of the leptin receptor in human leukaemic blast cells. Br J Haematol 1998;102:740-5
5. Tsuchiya T, Shimizu H, Horie M, et al. Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol 1999;365:273-9
6. Armand S, Yves C, Claude H, et al. Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum. Mol Neurol 1997;8:3123-6
7. Campfield LA, Smith FJ, Burn P. The OB protein (leptin) pathway - a link between adipose tissue mass and central neural networks. Horm Metab Res 1996;28:619-32
8. Cunningham MJ, Clifton DK, Steiner RA. Leptin's actions on the reproductive axis: perspectives and mechanisms. Biol Reprod 1999;60:216-22
9. Sierra-Honigmann MR, Nath AK, Murakami C, et al. Biological action of leptin as an angiogenic factor. Science 1998;281:1683-6
10. Konopleva M, Mikhail A, Estrov Z, et al. Expression and function of leptin receptor isoforms in myeloid leukemia and myelodysplastic syndromes: proliferative and anti-apoptotic activities. Blood 1999;93:1668-76
11. Bennett BD, Solar GP, Yuan JQ, et al. A role for leptin and its cognate receptor in hematopoiesis. Curr Biol 1996;6:1170-80
12. Lord GM, Matarese G, Howard JK, et al. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 1998;394:897-901
13. Consuelo MR, Jose SA, Raimundo G, et al. Human leptin enhances activation and proliferation of human circulating T lymphocytes. Cell Immunol 2000;199:15-24
14. Ducy P, Amling M, Takeda S, et al. Leptin inhibits bone formation through a hypothalamic relay: a central control of bone mass. Cell 2000;100:197-207
15. Reseland JE, Syversen U, Bakke I, et al. Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization. J Bone Miner Res 2001;16:1426-33
16. Mercer JG, Hoggard N, Williams LM, et al. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996;387:113-16
17. Lee YJ, Park JH, Ju SK, et al. Leptin receptor isoform expression in rat osteoblasts and their functional analysis. FEBS Lett 2000;528:43-7
18. Gordeladze JO, Drevon CA, Syversen V, et al. Leptin stimulates human osteoblastic cell proliferation, de novo collagen synthesis, and mineralization: impact on differentiation markers, apoptosis, and osteoclastic signaling. J Cell Biochem 2002;85:825-36
19. Wolf G, Hamann A, Han DC, et al. Leptin stimulates proliferation and TGF-beta expression in renal glomerular endothelial cells: potential role in glomerulosclerosis. Kidney Int 1999;56:1154-5
20. Tanabe K, Okuya S, Tanizawa Y, et al. Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. Biochem Biophys Res Commun 1997;241:765-8
21. Glasgow A, Bornstein SR, Chrousos GP, et al. Detection of ob-receptor in human adrenal neoplasms and effect of leptin on adrenal cell proliferation. Hum Metab Res 1999;31:247-51
22. Jin L, Burguera BG, Couce ME, et al. Leptin and leptin receptor expression in normal and neoplastic human pituitary: evidence of regulatory role for leptin on pituitary cell proliferation. J Clin Endocrinol Metab 1999;84:2903-11
23. Shimabukuro M, Wang MY, Zhou YT, et al. Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression. Proc Natl Acad Sci USA 1998;95:9558-61
24. Hay E, Lemonnier J, Fromifue O, et al. Bone morphogenic protein-2 promotes osteoblast apoptosis through a smad-independent, protein kinase C- dependent signaling pathway. J Biol Chem 2001;276:29028-36
25. Kitajima I, Soejima Y, Takasaki I, et al. Ceramide-induced nuclear translocation of nf-kappa B is a potential mediator of the apoptotic response to TNF-alpha in murine clonal osteoblasts. Bone 1996;19:263-70
26. Robert LJ, Robert SW, Teresita B, et al. Osteoblast programmed cell death (apoptosis): modulation by growth factors and cytokines. J Bone Miner Res 1998;13:793-802
27. Rittling SR, Matsumoto HN, McKee MD, et al. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res 1998;13:1101-11
28. Yoshitake H, Rittling SR, Denhardt DT, et al. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci USA 1999;96:8156-60