Differential phosphorylation of translation initiation regulators 4EBP1, S6k1, and Erk 1/2 following inhibition of alcohol metabolism in mouse heart

Cardiovascular Toxicology

Volumn 8, Issue 1, 2008, Pages 23-32

  Vary, Thomas C ^a   Lang, Charles H ^a  

^a PENN STATE COLLEGE OF MEDICINE   (United States)

Author keywords

4 Methylpyrazole; 4EBP1; Cyanamide; Erk 1 2; S6k1

Indexed keywords

4 METHYLPYRAZOLE; ALCOHOL; ALDEHYDE DEHYDROGENASE; CYANAMIDE; INITIATION FACTOR 4E BINDING PROTEIN 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; S6 KINASE;

ALCOHOL INTOXICATION; ALCOHOL METABOLISM; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HEART; HEART MUSCLE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ALCOHOL DEHYDROGENASE; ANIMALS; CARRIER PROTEINS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CYANAMIDE; DISEASE MODELS, ANIMAL; ENZYME INHIBITORS; ETHANOL; EUKARYOTIC INITIATION FACTORS; HEART; INJECTIONS, INTRAPERITONEAL; MICE; MICE, INBRED STRAINS; MITOGEN-ACTIVATED PROTEIN KINASE 3; MYOCARDIUM; PHOSPHOPROTEINS; PHOSPHORYLATION; PYRAZOLES; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SPECIFIC PATHOGEN-FREE ORGANISMS;

EID: 49349116809     PISSN: 15307905     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12012-008-9012-4     Document Type: Article

References (56)

1. E. Adickes T. J. Mollner S. Lockwood 1990 Ethanol-induced morphologic alterations during growth and maturation of cardiac myocytes Alcoholism Clinical and Experimental Research 14 827 831
2. T. C. Vary G. Deiter 2004 Chronic alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart Metabolism 54 212 219
3. C. H. Lang R. A. Frost A. D. Sumner T. C. Vary 2005 Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart International Journal of Biochemistry and Cell Biology 37 2180 2195
4. Vary, T. C., & Sumner, A. D. (2004). Deleterious effects of alcohol intoxication on heart: Arrhythmias to cardiomyopathies. In R. R. Watson, & Preedy, V. (Eds.), Nutrition and alcohol: Linking nutrient interactions and dietary intake (pp. 117-141). Boca Raton, FL: CRC Press.
5. C. H. Lang R. A. Frost V. Kumar T. C. Vary 2000 Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F American Journal of Physiology. Endocrinology and Metabolism 279 E1029 E1038
6. C. H. Lang S. R. Kimball R. A. Frost T. C. Vary 2001 Alcohol myopathy: Impairment of protein synthesis and translation initiation International Journal of Biochemistry and Cell Biology 33 457 473
7. T. C. Vary A. C. Nairn G. Deiter C. H. Lang 2002 Differential effects of alcohol consumption on eukaryotic elongation factors in heart, skeletal muscle and liver Alcoholism Clinical and Experimental Research 2 1794 1802
8. T. C. Vary G. Deiter S. A. Goodman 2005 Acute alcohol intoxication enhances myocardial eIF4G phosphorylation despite reducing mTOR signaling American Journal of Physiology. Heart and Circulatory Physiology 288 H121 H128
9. T. C. Vary C. J. Lynch C. H. Lang 2001 Effects of chronic alcohol consumption on regulation of myocardial protein synthesis American Journal of Physiology. Heart and Circulatory 281 H1242 H1251
10. T. C. Vary A. C. Nairn C. H. Lang 2004 Restoration of protein synthesis in heart and skeletal muscle after withdrawal of alcohol Alcoholism, Clinical and Experimental Research 28 517 525
11. B. Raught A. -C. Gingras 1999 eIF4E activity is regulated at multiple levels International Journal of Biochemistry and Cell Biology 31 43 57
12. R. E. Rhoads S. Joshi-Barve W. B. Minich 1994 Participation of initiation factors in recruitment of mRNA to ribosomes Biochimie 76 831 838
13. R. E. Rhoads 1993 Regulation of eukaryotic protein synthesis by initiation factors Journal of Biological Chemistry 268 3017 3020
14. S. Farrari G. Thomas 1994 S6 phosphorylation and the p70(s6k)/p85(s6k) Critical Reviews in Biochemistry and Molecular Biology 29 385 413
15. s6k EMBO J 16 3693 3704
16. H. B. Jefferies C. Reinhard S. C. Kozma G. Thomas 1994 Rapamycin selectively represses translation of the 'polypyrimidine tract' mRNA family Proceedings of the National Academy of Sciences USA 91 4441 4445
17. Q. -P. Weng M. Kozlowski C. Belham A. Zhang M. J. Comb J. Avruch 1998 Regulation of the p70 S6 kinase by phosphorylation in vivo: Analysis using site-specific anti-phosphopeptide antibodies Journal of Biological Chemistry 273 16621 16629
18. Q. -P. Weng K. Anadrabi M. T. Kozlowski J. R. Grove J. Avruch 1998 Multiple independent inputs are required for activation of the p70 S6 kinase Molecular and Cellular Biology 15 2333 2340
19. R. A. Deitrich T. V. Dunwiddie R. A. Harris V. G. Erwin 1989 Mechanism of action of ethanol: Initial central nervous system actions Pharmacological Reviews 41 489 537
20. S. Cheema-Dhadli F. A. Halperin K. Sonnenberg V. MacMillan M. L. Halperin 1987 Regulation of ethanol metabolism in the rat Biochemistry and Cell Biology 65 458 466
21. J. F. Brien C. W. Loomis 1983 Pharmacology of acetaldehyde Canadian Journal of Physiology and Pharmacology 61 1 22
22. N. S. Aberle J. Ren 2003 Short-term acetaldehyde exposure depresses ventricular myocyte contraction: Role of cytochrome P450 oxidase, xanthine oxidase, and lipid peroxidation Alcoholism, Clinical and Experimental Research 27 577 583
23. R. Blomstrand H. Theorell 1970 Inhibitory effect on ethanol oxidation in man after administration of 4-methylpyrazole Life Science 9 631 640
24. T. K. Li H. Theorell 1969 Human liver alcohol dehydrogenase: Inhibition by pyrazole analogs Acta Chemica Scandinavica 23 892 902
25. R. Pietruszko 1975 Human liver alcohol dehydrogenase: Inhibition of methanol activity by pyrazole, 4-methylpyrazole, 4-hydroxymethylpyrazole and 4-carboxypyrazole Biochemical Pharmacology 24 1603 1607
26. T. Ehrig W. Bosron T. K. Li 1990 Alcohol and aldehyde dehydrogenase Alcohol and Alcoholism 25 105 116
27. D. E. Feierman A. I. Cederbaum 1986 Inhibition of microsomal oxidation of ethanol by pyrazole and 4-methylpyrazole in vitro Biochemical Journal 239 671 677
28. 3H]phenylalanine Biochemical Journal 192 719 723
29. T. C. Vary G. Deiter 2005 Long-term alcohol administration inhibits synthesis of both myofibrillar and sarcoplasmic proteins in heart Metabolism: Clinical and Experimental 54 212 219
30. T. C. Vary S. R. Kimball 1992 Sepsis-induced changes in protein synthesis: Differential effects on fast- and slow-twitch muscles American Journal of Physiology 262 C1513 C1519
31. T. C. Vary S. R. Kimball 1992 Regulation of hepatic protein synthesis in chronic inflammation and sepsis American Journal of Physiology. Cell Physiology 262 C445 C452
32. D. Drnevich T. C. Vary 1993 Analysis of physiological amino acids using dabsyl derivatization and reverse-phase liquid chromatography Journal of Chromatography 613 137 144
33. E. McKee J.-Y. Cheung D. E. Rannels H. E. Morgan 1978 Measurement of the rate of protein synthesis and compartmentation of heart phenylalanine Journal of Biological Chemistry 253 1030 1040
34. I. H. Williams B. H. L. Chua R. Sahma D. Siehl H. E. Morgan 1980 Effects of diabetes on protein turnover in cardiac muscle American Journal of Physiology. Endocrinology and Metabolism 239 E178 E185
35. G. Caso C. Ford S. Nair P. J. Garlick M. A. McNurlan 2002 Aminoacyl-tRNA enrichment after a flood of labeled phenylalanine: Insulin effect on muscle protein synthesis American Journal of Physiology. Endocrinology and Metabolism 282 E1029 E1038
36. V. Kumar C. Silvis G. Nystrom N. Deshpande T. C. Vary R. A. Frost C. H. Lang 2002 Alcohol-induced increase in insulin-like growth factor binding protein- are partially mediated by TNF Alcoholism, Clinical and Experimental Research 26 1574 1583
37. C. H. Lang A. M. Pruznal N. Deshpande M. M. Palopoli R. A. Frost T. C. Vary 2004 Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independent of ethanol metabolism Alcoholism, Clinical and Experimental Research 28 1758 1767
38. T. C. Vary L. S. Jefferson S. R. Kimball 2000 Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused skeletal muscle American Journal of Physiology. Endocrinology and Metabolism 278 E58 E64
39. T. C. Vary S. R. Kimball 2000 Effect of sepsis on eIF4E availability in skeletal muscle American Journal of Physiology. Endocrinology and Metabolism 279 E1178 E1184
40. T. C. Vary L. S. Jefferson S. R. Kimball 2001 Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1 American Journal of Physiology. Endocrinology and Metabolism 281 E1045 E1053
41. T. C. Vary C. H. Lang 2005 IGF-I activates the eIF4F system in cardiac muscle in vivo Molecular and Cellular Biochemistry 272 209 220
42. T. C. Vary G. Deiter C. H. Lang 2004 Diminished Erk 1/2 and p38 MAPK phosphorylation in skeletal muscle during sepsis Shock 22 548 554
43. S. C. Kozma G. Thomas 1994 p70s6k/p85s6k: Mechanism of activation and role in mitogenesis Cancer Biology 5 255 266
44. C. Lang D. Wu R. Frost L. Jefferson S. Kimball T. Vary 1999 Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E American Journal of Physiology 277 E268 E276
45. C. H. Lang R. A. Frost V. Kumar D. Wu T. C. Vary 2000 Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver Alcoholism, Clinical and Experimental Research 24 322 331
46. C. H. Lang V. Kumar X. Liu R. A. Frost T. C. Vary 2003 IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication Alcoholism, Clinical and Experimental Research 27 485 494
47. J. Avruch 1998 Insulin signal transduction through protein kinase cascades Molecular and Cellular Biochemistry 182 31 42
48. A. Haghihat S. Maderr A. Pause N. Sonenberg 1995 Repression of cap-dependent translation by 4E-binding protein I: Competition with p220 for binding to eukaryotic initiation factor-4E EMBO J 14 5701 5709
49. S. R. Kimball R. L. Horetsky L. S. Jefferson 1998 Signal transduction pathways involved in the regulation of protein synthesis by insulin in L6 myoblasts American Journal of Physiology 274 C221 C228
50. T. Lin X. Kong A. R. Saltiel P. J. Blackshear J. C. Lawrence 1995 Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase dependent pathway Journal of Biological Chemistry 270 18531 18535
51. T. Lin X. Kong T. Haystead A. Pause G. Belsham N. Sonnenberg J. Lawrence 1994 PHAS-I as a link between mitogen activated protein kinase and translation initiation Science 266 653 656
52. A. Pause G. J. Belsham A. -C. Gingras O. Donze T. -A. Lin J. C. Lawrence N. Sonenberg 1994 Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function Nature 371 762 767
53. A. Fabbri G. Marchesini A. M. Moselli-Labate F. Rossi A. Cicognanni M. Dente T. Iervese S. Ruggeri U. Mengozzi A. Vandelli 2001 Blood alcohol concentration and management of road trauma patients in emergency department Journal of Trauma 50 521 528
54. K. Hara K. Yonezawa Q. -P. Weng M. Kozlowski C. Belham J. Avruch 1998 Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF4E-BP1 through a common effector molecule Journal of Biological Chemistry 273 14484 14494
55. A. -C. Gingras S. P. Gygi B. Raught 1999 Regulation of 4E-BP1 phosphorylation: a novel 2-step mechanism Genes and Development 13 1422 1437
56. S. Isotoni K. Hara C. Tokunaga H. Inoue J. Avruch K. Yomezawa 1999 Immunopurified mammalian target of rapamycin phosphorylates p70 S6 kinase alpha in vitro Journal of Biological Chemistry 274 34493 34498