Multiple independent inputs are required for activation of the p70 S6 kinase

Molecular and Cellular Biology

Volumn 15, Issue 5, 1995, Pages 2333-2340

  Weng, Qing Ping ^a   Andrabi, Khurshid ^a   Kozlowski, Mark T ^a   Grove, J Russell ^a,b   Avruch, Joseph ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b AFFYMAX RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE; RAPAMYCIN; WORTMANNIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; DELETION MUTANT; ENZYME ACTIVATION; ENZYME INHIBITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

EID: 0028939115     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.15.5.2333     Document Type: Article

References (18)

1. Banerjee, P., M. D. Ahmad. J. R. Grove, C. Kozlosky, D. J. Price, and J. Avruch. 1990. Molecular structure of a major insulin/mitogen-activated 70-kDa S6 protein kinase. Proc. Natl. Acad. Sci. USA 87:8550-8554.
2. Brown, E. J., M. W. Albers. T. B. Shin, K. Ichikawa, C. T. Keith, W. S. Lane, and S. L. Schreiber. 1994. A mammalian protein targeted by G1-arresting rapamycin-receptor complex. Nature (London) 369:756-758.
3. S6K activation mediated by phosphatidylinositol-30H kinase. Nature (London) 370:71-75.
4. Chung, J., C. J. Kuo, C. R. Crabtree, and J. Blenis. 1992. Rapamycin-FKBP specificity blocks growth-dependent activation of signalling by the 70kd S6 protein kinase. Cell 69:1227-1236.
5. Erikson. R. L. 1991. Structure, expression and regulation of protein kinases involved in phosphorylation of ribosomal protein S6. J. Biol. Chem. 266: 6007-6010.
6. S6K is associated with phosphorylation of four clustered sites displaying Ser/Thr-Pro motifs. Proc. Natl. Acad. Sci. USA 89:7282-7286.
7. S6K through dephosphorylation of a novel set of sites. J. Biol. Chem. 268:16091-16094.
8. Field, J., J.-I. Nikawa, D. Broek. B. MacDonald, L. Rodgers, I. A. Wilson, R. A. Lerner, and M. Wigler. 1988. Purification of Ras-responsive adenylyl cyclase complex from Saccharomyees cercvisiae by use of an epitope addition method. Mol. Cell. Biol. 8:2159-2165.
9. Grove, J. R., P. Banerjee, A. Balasubramanyam, P. J. Coffer, D. J. Price, J. Avruch, and J. R. Woodgett. 1991. Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol. Cell. Biol. 11:5541-5550.
10. Grove, J. R., D. J. Price, P. Banerjee, A. Balasubramanyam, M. F. Ahmad, and J. Avruch. 1993. Regulation of an epitope-tagged recombinant Rsk-1 S6 kinase by phorbol ester and erk/MAP kinase. Biochemistry 32:7727-7738.
11. Kyriakis, J. M., and J. Avruch. 1994. S6 kinases: sequential intermediates in insulin/mitogen-activated protein kinase cascades, p. 85-148. In J. R. Woodgett, Protein kinases. Oxford University Press, Oxford.
12. Mukhopadhyay, N. K., D. J. Price, J. M. Kyriakis, S. J. Pelech, J. Sanghera, and J. Avruch. 1992. An array of insulin-activated, proline-directed (Ser/ Thr) protein kinases phosphorylate the p70 S6 kinase. J. Biol. Chem. 267: 3325-3335.
13. Price, D. J., J. R. Grove, V. Calvo, J. Avruch, and B. E. Bierer. 1992. Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase. Science 257:973-977.
14. Price, D. J., N. K. Mukhopadhyay, and J. Avruch. 1991. Insulin-activated kinases phosphorylate a pseudosubstrate synthetic inhibitor of the p70 S6 kinase. J. Biol. Chem. 266:16281-16284.
15. Price, D. J., R. A. Nemenoff, and J. Avruch. 1989. Purification of a hepatic S6 kinase from cychoheximide-treated rats. J. Biol. Chem. 264:13825-13833.
16. Sabatini, D. M., H. Erdjume, M. L. Bromage, P. Tempst, and S. H. Snyder. 1994. RAFT1: a mammalian protein that binds to FKPB12 in a rapamycin-dependent fashion and is homologous to yeast TORs. Cell 78:35-43.
17. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual. 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor. N.Y.
18. Sturgill, T. W., L. B. Ray, E. Erikson, and J. L. Mailer. 1988. Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II. Nature (London) 334:715-718.