Regulation of the RelA (p65) transactivation domain

Biochemical Society Transactions

Volumn 36, Issue 4, 2008, Pages 603-608

  O'Shea, John M ^a   Perkins, Neil D ^a,b  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Co activator; Co repressor; Nuclear factor B (NF B); p65; RelA; Transactivation

Indexed keywords

DNA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TATA BINDING PROTEIN; TRANSCRIPTION FACTOR RELA;

AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL FUNCTION; DNA BINDING; DOWN REGULATION; GENE CONTROL; GENETIC CONSERVATION; HUMAN; MISSENSE MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; TRANSACTIVATION;

AMINO ACID MOTIFS; ANIMALS; GENE EXPRESSION REGULATION; HUMANS; LIGASES; PROTEIN BINDING; TRANS-ACTIVATION (GENETICS);

EID: 49349094024     PISSN: 03005127     EISSN: None     Source Type: Journal    
DOI: 10.1042/BST0360603     Document Type: Review

References (41)

1. Pahl, H.L. (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18, 6853-6866
2. Perkins, N.D. (2007) Integrating cell-signalling pathways with NF-κB and IKK function. Nat. Rev. Mol. Cell Biol. 8, 49-62
3. Gauthier, M. and Degnan, B.M. (2008) The transcription factor NF-κB in the demosponge Amphimedon queenslondica: insights on the evolutionary origin of the Rel homology domain. Dev. Genes Evol. 218, 23-32
4. Sullivan, J.C., Kalaitzidis, D., Gilmore, T.D. and Finnerty, J.R. (2007) Rel homology domain-containing transcription factors in the cnidarian Nemotostella vectensis. Dev. Genes Evol. 217, 63-72
5. Hayden, M.S. and Ghosh, S. (2008) Shared principles in NF-κB signaling. Cell 132, 344-362
6. Kumar, A., Takada, Y., Boriek, A.M. and Aggarwal, B.B. (2004) Nuclear factor-κB: its role in health and disease. J. Mol. Med. 82, 434-448
7. Greten, F.R. and Karin, M. (2004) The IKK/NF-κB activation pathway: a target for prevention and treatment of cancer. Cancer Lett. 206, 193-199
8. Kim, H.J., Hawke, N. and Baldwin, A.S. (2006) NF-κB and IKK as therapeutic targets in cancer. Cell Death Differ. 13, 738-747
9. Perkins, N.D. and Gilmore, T.D. (2006) Good cop, bad cop: the different faces of NF-κB. Cell Death Differ. 13, 759-772
10. Schmitz, M.L. and Baeuerle, P.A. (1991) The p65 subunit is responsible for the strong transcription activating potential of NF-κB. EMBO J. 10, 3805-3817
11. Schmitz, M.L., dos Santos Silva, M.A., Altmann, H., Czisch, M., Holak, T.A. and Baeuerle, P.A. (1994) Structural and functional analysis of the NF-κB p65 C terminus: an acidic and modular transactivation domain with the potential to adopt an α-helical conformation. J. Biol. Chem. 269, 25613-25620
12. Blair, W.S., Bogerd, H.P., Madore, S.J. and Cullen, B.R. (1994) Mutational analysis of the transcription activation domain of ReIA: identification of a highly synergistic minimal acidic activation module. Mol. Cell. Biol. 14, 7226-7234
13. Plevin, M.J., Mills, M.M. and Ikura, M. (2005) The LxxLL motif: a multifunctional binding sequence in transcriptional regulation. Trends Biochem. Sci. 30, 66-69
14. Perkins, N.D. (2006) Post-translational modifications regulating the activity and function of the nuclear factor κB pathway. Oncogene 25, 6717-6730
15. Moore, P.A., Ruben, S.M. and Rosen, C.A. (1993) Conservation of transcriptional activation functions of the NF-κB p50 and p65 subunits in mammalian cells and Sacchromyces cerevisiae. Mol. Cell. Biol. 13, 1666-1674
16. Ballard, D.W., Dixon, E.P., Peffer, N.J., Bogerd, H., Doerre, S., Stein, B. and Greene, W.C. (1992) The 65-kDa subunit of human NF-κB functions as a potent transcriptional activator and a target for v-Rel-mediated repression. Proc. Natl. Acad. Sci. U.S.A. 89, 1875-1879
17. Harhaj, E.W. and Sun, S.C. (1999) Regulation of ReIA subcellular localization by a putative nuclear export signal and p50. Mol. Cell. Biol. 19, 7088-7095
18. Ruben, S.M., Narayanan, R., Klement, J.F., Chen, C.H. and Rosen, C.A. (1992) Functional characterization of the NF-κB p65 transcriptional activator and an alternatively spliced derivative. Mol. Cell. Biol. 12, 444-454
19. Schmitz, M.L., dos Santos Silva, M.A. and Baeuerle, P.A. (1995) Transactivation domain 2 (TA2) of p65 NF-κB: similarity to TA1 and phorbol ester-stimulated activity and phosphorylation in intact cells. J. Biol. Chem. 270, 15576-15584
20. Trecca, D., Guerrini, L., Fracchiolla, N.S., Pomati, M., Baldini, L., Maiolo, A.T. and Neri, A. (1997) Identification of a tumor-associated mutant form of the NF-κB ReIA gene with reduced DNA-binding and transactivating activities. Oncogene 14, 791-799
21. Campbell, K.J., Witty, J.M., Rocha, S. and Perkins, N.D. (2006) Cisplatin mimics ARF tumor suppressor regulation of ReIA (p65) nuclear factor-κB transactivation. Cancer Res. 66, 929-935
22. Rocha, S., Garrett, M.D., Campbell, K.J., Schumm, K. and Perkins, N.D. (2005) Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 24, 1157-1169
23. Buss, H., Dorrie, A., Schmitz, M.L., Hoffmann, E., Resch, K. and Kracht, M (2004) Constitutive and interleukin-1-inducible phosphorylation of p65 NF-κB at serine 536 is mediated by multiple protein kinases including IκB kinase (IKK)-α, IKKβ, IKKε, TRAF family member-associated (TANK)-binding kinase 1 (TBK1), and an unknown kinase and couples p65 to TATA-binding protein-associated factor II31-mediated interieukin-8 transcription. J. Biol. Chem. 279, 55633-55643
24. Schmitz, M.L., Stelzer, G., Altmann, H., Meisterernst, M. and Baeuerle, P.A. (1995) Interaction of the COOH-terminal transactivation domain of p65 NF-κB with TATA-binding protein, transcription factor IIB, and coactivators. J. Biol. Chem. 270, 7219-7226
25. Gerritsen, M.E., Williams, A.J., Neish, A.S., Moore, S., Shi, Y. and Collins, T. (1997) CREB-binding protein/p300 are transcriptional coactivators of p65. Proc. Natl. Acad. Sci. U.S.A. 94, 2927-2932
26. Perkins, N.D., Felzien, L.K., Betts, J.C., Leung, K., Beach, D.H. and Nabel, G.J. (1997) Regulation of NF-κB by cyclin-dependent kinases associated with the p300 coactivator. Science 275, 523-527
27. Asamitsu, K., Tetsuka, T., Kanazawa, S. and Okamoto, T. (2003) RING finger protein AO7 supports NF-κB-mediated transcription by interacting with the transactivation domain of the p65 subunit. J. Biol. Chem. 278, 26879-26887
28. Uranishi, H., Tetsuka, T., Yamashita, M., Asamitsu, K., Shimizu, M., Itoh, M. and Okamoto, T. (2001) Involvement of the pro-oncoprotein TLS (translocated in liposarcoma) in nuclear factor-κB p65-mediated transcription as a coactivator. J. Biol. Chem. 276, 13395-13401
29. Tetsuka, T., Uranishi, H., Sanda, T., Asamitsu, K., Yang, J.P., Wong-Staal, F. and Okamoto, I. (2004) RNA helicase A interacts with nuclear factor κB p65 and functions as a transcriptional coactivator. Eur. J. Biochem. 271, 3741-3751
30. Naar, A.M., Beaurang, P.A., Zhou, S., Abraham, S., Solomon, W. and Tjian, R. (1999) Composite co-activator ARC mediates chromatin-directed transcriptional activation. Nature 398, 828-832
31. Guermah, M., Malik, S. and Roeder, R.G. (1998) Involvement of TFIID and USA components in transcriptional activation of the human immunodeficiency virus promoter by NF-κB and Sp1. Mol. Cell. Biol. 18, 3234-3244
32. Owen, H.R., Quadroni, M., Bienvenut, W., Buerki, C. and Hottiger, M.O. (2005) Identification of novel and cell type enriched cofactors of the transcription activation domain of ReIA (p65 NF-κB). J. Proteome Res. 4, 1381-1390
33. Owen, H.R., Elser, M., Cheung, E., Gersbach, M., Kraus, W.L. and Hottiger, M.O. (2007) MYBBP1a is a novel repressor of NF-κB. J. Mol. Biol. 366, 725-736
34. Tetsuka, T., Uranishi, H., Imai, H., Ono, T., Sonta, S., Takahashi, N., Asamitsu, K. and Okamoto, T. (2000) Inhibition of nuclear factor-κB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. J. Biol. Chem. 275, 4383-4390
35. Sammons, M., Wan, S.S., Vogel, N.L., Mientjes, E.J., Grosveld, G. and Ashburner, B.P. (2006) Negative regulation of the ReIA/p65 transactivation function by the product of the DEK proto-oncogene. J. Biol. Chem. 281, 26802-26812
36. Arlt, A., Rosenstiel, P., Kruse, M.L., Grohmann, F., Minkenberg, J., Perkins, N.D., Folsch, U.R., Schreiber, S. and Schafer, H. (2008) IEX-1 directly interferes with ReIA/p65 dependent transactivation and regulation of apoptosis. Biochim. Biophys. Acta 1783, 941-952
37. dela Paz, N.G., Simeonidis, S., Leo, C., Rose, D.W. and Collins, T. (2007) Regulation of NF-κB-dependent gene expression by the POU domain transcription factor Oct-1. J. Biol. Chem. 282, 8424-8434
38. Espinosa, L., Ingles-Esteve, J., Robert-Moreno, A. and Bigas, A. (2003) IκBα and p65 regulate the cytoplasmic shuttling of nuclear compressors: cross-talk between Notch and NFκB pathways. Mol. Biol. Cell. 14, 491-502
39. Liu, B., Yang, R., Wong, K.A., Getman, C., Stein, N., Teitell, M.A., Cheng, G., Wu, H. and Shuai, K. (2005) Negative regulation of NF-κB signaling by PIAS1. Mol. Cell. Biol. 25, 1113-1123
40. Yang, J., Fan, G.H., Wadzinski, B.E., Sakurai, H. and Richmond, A. (2001) Protein phosphatase 2A interacts with and directly dephosphorylates ReIA. J. Biol. Chem. 276, 47828-47833
41. Jeong, S.J., Radonovich, M., Brady, J.N. and Pise-Masison, C.A. (2004) HTLV-I Tax induces a novel interaction between p65/ReIA and p53 that results in inhibition of p53 transcriptional activity. Blood 104, 1490-1497