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Volumn 24, Issue 3-4, 2007, Pages 246-253

Generation and characterization of recombinant vaccinia viruses expressing a hepatitis C virus Core protein, genotype 1b, individually or as a polyprotein

Author keywords

Cellular immunity; HCV; IFN gamma; Replication; Vaccinia

Indexed keywords

CORE PROTEIN; GAMMA INTERFERON; POLYPROTEIN; VIRUS ANTIGEN;

EID: 49249133111     PISSN: 08644551     EISSN: 10272852     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (3)

References (53)
  • 1
    • 33749362060 scopus 로고    scopus 로고
    • The status of liver transplantation for hepatitis C
    • Cameron AM, Busuttil RW. The status of liver transplantation for hepatitis C. Expert Opin Biol Ther (2006); 6:993-1002.
    • (2006) Expert Opin Biol Ther , vol.6 , pp. 993-1002
    • Cameron, A.M.1    Busuttil, R.W.2
  • 2
    • 33845284536 scopus 로고    scopus 로고
    • The changing epidemiology and natural history of hepatitis C virus infection
    • Bialek SR, Terrault NA. The changing epidemiology and natural history of hepatitis C virus infection. Clin Liver Dis. (2006); 10:697-715.
    • (2006) Clin Liver Dis , vol.10 , pp. 697-715
    • Bialek, S.R.1    Terrault, N.A.2
  • 3
    • 33751041515 scopus 로고    scopus 로고
    • Antiviral treatment of hepatitis C: Present status and future prospects
    • Koike K. Antiviral treatment of hepatitis C: present status and future prospects. J Infect Chemother (2006); 12:227-32.
    • (2006) J Infect Chemother , vol.12 , pp. 227-232
    • Koike, K.1
  • 4
    • 33846423215 scopus 로고    scopus 로고
    • Natural products and chronic hepatitis C virus
    • Azzam HS, Goertz C, Fritts M, Jonas WB. Natural products and chronic hepatitis C virus. Liver Int (2007); 27:17-25.
    • (2007) Liver Int , vol.27 , pp. 17-25
    • Azzam, H.S.1    Goertz, C.2    Fritts, M.3    Jonas, W.B.4
  • 5
    • 0344443242 scopus 로고    scopus 로고
    • Replication of the hepatitis C virus in cell culture
    • Bartenschlager R, Kaul A, Sparacio S. Replication of the hepatitis C virus in cell culture. Antiviral Res (2003); 60:91-102.
    • (2003) Antiviral Res , vol.60 , pp. 91-102
    • Bartenschlager, R.1    Kaul, A.2    Sparacio, S.3
  • 6
    • 32044443616 scopus 로고    scopus 로고
    • Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens
    • Kuzushita N, Gregory SH, Monti NA, Carlson R, Gehring S, Wands JR. Vaccination with protein-transduced dendritic cells elicits a sustained response to hepatitis C viral antigens. Gastroenterology. (2006); 130:453-64.
    • (2006) Gastroenterology , vol.130 , pp. 453-464
    • Kuzushita, N.1    Gregory, S.H.2    Monti, N.A.3    Carlson, R.4    Gehring, S.5    Wands, J.R.6
  • 7
    • 13944257273 scopus 로고    scopus 로고
    • CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection
    • Alatrakchi N, Graham CS, He Q, Sherman KE, Koziel MJ. CD8+ cell responses to hepatitis C virus (HCV) in the liver of persons with HCV-HIV coinfection versus HCV monoinfection. J Infect Dis. (2005); 191:702-9.
    • (2005) J Infect Dis , vol.191 , pp. 702-709
    • Alatrakchi, N.1    Graham, C.S.2    He, Q.3    Sherman, K.E.4    Koziel, M.J.5
  • 8
    • 33744527480 scopus 로고    scopus 로고
    • Multigenotype HCV-NS3 recombinant vaccinia viruses as a model for evaluation of cross-genotype immunity induced by HCV vaccines in the mouse
    • Eisenbach C, Freyse A, Lupu CM, Weigand K, Ernst E, Hoyler B, Stremmel W et al. Multigenotype HCV-NS3 recombinant vaccinia viruses as a model for evaluation of cross-genotype immunity induced by HCV vaccines in the mouse. Vaccine. (2006); 24:5140-8.
    • (2006) Vaccine , vol.24 , pp. 5140-5148
    • Eisenbach, C.1    Freyse, A.2    Lupu, C.M.3    Weigand, K.4    Ernst, E.5    Hoyler, B.6    Stremmel, W.7
  • 9
    • 0037971371 scopus 로고    scopus 로고
    • hepatitis C Virus Core Protein Selectively Inhibits Synthesis and Accumulation of p21/Waf1 and Certain Nuclear Proteins
    • Oka K, Nagano-Fujii M, Yoshida I, Hidajat R, Deng L, Akutsu M et al. hepatitis C Virus Core Protein Selectively Inhibits Synthesis and Accumulation of p21/Waf1 and Certain Nuclear Proteins. Microbiol Immunol (2003); 47:429-38.
    • (2003) Microbiol Immunol , vol.47 , pp. 429-438
    • Oka, K.1    Nagano-Fujii, M.2    Yoshida, I.3    Hidajat, R.4    Deng, L.5    Akutsu, M.6
  • 10
    • 0037385582 scopus 로고    scopus 로고
    • Amino acids 1-20 of the hepatitis C virus (HCV) core protein specifically inhibit HCV IRES-dependent translation in HepG2 cells, and inhibit both HCV IRES- and cap-dependent translation in HuH7 and CV-1 cells
    • Li D, Takyar ST, Lott WB, Gowans EJ. Amino acids 1-20 of the hepatitis C virus (HCV) core protein specifically inhibit HCV IRES-dependent translation in HepG2 cells, and inhibit both HCV IRES- and cap-dependent translation in HuH7 and CV-1 cells. J Gen Virol (2003); 84:815-25.
    • (2003) J Gen Virol , vol.84 , pp. 815-825
    • Li, D.1    Takyar, S.T.2    Lott, W.B.3    Gowans, E.J.4
  • 11
    • 0025862146 scopus 로고
    • Molecular biology of the hepatitis C virus: Implications for diagnosis, development, and control of viral disease
    • Houghton M, Weiner A, Han J, Kuo G, Choo Q-L. Molecular biology of the hepatitis C virus: implications for diagnosis, development, and control of viral disease. Hepatology (1991); 14:381-6.
    • (1991) Hepatology , vol.14 , pp. 381-386
    • Houghton, M.1    Weiner, A.2    Han, J.3    Kuo, G.4    Choo, Q.-L.5
  • 13
    • 0035928765 scopus 로고    scopus 로고
    • hepatitis C virus core protein: Intriguing properties and functional relevance
    • Ray RB, Ray R. hepatitis C virus core protein: intriguing properties and functional relevance. FEMS Microbiol Lett (2001); 202:149-56.
    • (2001) FEMS Microbiol Lett , vol.202 , pp. 149-156
    • Ray, R.B.1    Ray, R.2
  • 14
    • 4644276886 scopus 로고    scopus 로고
    • Activation of RB/E2F signaling pathway is required forthe modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells
    • Hassan M, Ghozlan H, Abdel-Kader O. Activation of RB/E2F signaling pathway is required forthe modulation of hepatitis C virus core protein-induced cell growth in liver and non-liver cells. Cell Signal (2004); 16:1375-85.
    • (2004) Cell Signal , vol.16 , pp. 1375-1385
    • Hassan, M.1    Ghozlan, H.2    Abdel-Kader, O.3
  • 15
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida T, Hanada T, Tokuhisa T, Kosai K, Sata M, Kohara M et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J Exp Med (2002); 196:641-53.
    • (2002) J Exp Med , vol.196 , pp. 641-653
    • Yoshida, T.1    Hanada, T.2    Tokuhisa, T.3    Kosai, K.4    Sata, M.5    Kohara, M.6
  • 16
    • 0033690901 scopus 로고    scopus 로고
    • Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation
    • Kittlesen DJ, Chianese-Bullock KA, Yao ZQ, Braciale TJ, Hahn YS. Interaction between complement receptor gC1qR and hepatitis C virus core protein inhibits T-lymphocyte proliferation. J Clin Invest (2000); 106:1239-49.
    • (2000) J Clin Invest , vol.106 , pp. 1239-1249
    • Kittlesen, D.J.1    Chianese-Bullock, K.A.2    Yao, Z.Q.3    Braciale, T.J.4    Hahn, Y.S.5
  • 17
    • 0035898948 scopus 로고    scopus 로고
    • A truncated HCV core protein elicits a potent immune response with a strong participation of cellular immunity components in mice
    • Álvarez-Obregon JC, Dueñas-Carrera S, Valenzuela C, Morales J. A truncated HCV core protein elicits a potent immune response with a strong participation of cellular immunity components in mice. Vaccine (2001); 19:3940-6.
    • (2001) Vaccine , vol.19 , pp. 3940-3946
    • Álvarez-Obregon, J.C.1    Dueñas-Carrera, S.2    Valenzuela, C.3    Morales, J.4
  • 19
    • 0022850168 scopus 로고
    • Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Discrete Peptides for Biological, Immunological, and Methodological Studies
    • Houghten RA, DeGraw ST, Bray MK, Hoffmann SR, Frizzell ND. Simultaneous Multiple Peptide Synthesis: The Rapid Preparation of Large Numbers of Discrete Peptides for Biological, Immunological, and Methodological Studies. Biotechniques (1986); 4:522-6.
    • (1986) Biotechniques , vol.4 , pp. 522-526
    • Houghten, R.A.1    DeGraw, S.T.2    Bray, M.K.3    Hoffmann, S.R.4    Frizzell, N.D.5
  • 20
    • 0345411634 scopus 로고    scopus 로고
    • Identification of Functional Domains in the 14-Kilodalton Envelope Protein (A27L) of Vaccinia Virus
    • Vázquez MI., Esteban M. Identification of Functional Domains in the 14-Kilodalton Envelope Protein (A27L) of Vaccinia Virus. J Virol (1999); 73:9098-109.
    • (1999) J Virol , vol.73 , pp. 9098-9109
    • Vázquez, M.I.1    Esteban, M.2
  • 21
    • 0034703848 scopus 로고    scopus 로고
    • A truncated variant of the hepatitis C virus core induces a slow but potent immune response in mice following DNA immunization
    • Dueñas-Carrera S, Álvarez-Lajonchere L, Alvarez- Obregón JC, Herrera A, Lorenzo LJ, Pichardo D et al. A truncated variant of the hepatitis C virus core induces a slow but potent immune response in mice following DNA immunization. Vaccine (2000); 19:992-7.
    • (2000) Vaccine , vol.19 , pp. 992-997
    • Dueñas-Carrera, S.1    Álvarez-Lajonchere, L.2    Alvarez- Obregón, J.C.3    Herrera, A.4    Lorenzo, L.J.5    Pichardo, D.6
  • 24
    • 0002654196 scopus 로고
    • The neutralization of vaccine virus by immune serum: Titration by the intracerebral inoculation of mice
    • Bronson LH, Parker RF. The neutralization of vaccine virus by immune serum: titration by the intracerebral inoculation of mice. J Bacteriol (1941); 41:56-7.
    • (1941) J Bacteriol , vol.41 , pp. 56-57
    • Bronson, L.H.1    Parker, R.F.2
  • 25
    • 84995189991 scopus 로고
    • Attenuation of virulent fowl pox virus in tissue culture and characteristics of the attenuated virus
    • Mayr A, Malicki K. Attenuation of virulent fowl pox virus in tissue culture and characteristics of the attenuated virus. Zentralbl Veterinarmed B (1966);13:1-13.
    • (1966) Zentralbl Veterinarmed B , vol.13 , pp. 1-13
    • Mayr, A.1    Malicki, K.2
  • 26
    • 49249132386 scopus 로고    scopus 로고
    • Álvarez-Lajonchere L, Dueñas Carrera S, Guerra I, Acosta-Rivero N, Musacchio A, Vázquez M, Recombinant live fowlpox virus vectors and their use in pharmaceutical compositions against hepatitis C virus. WO/2006/015557, 2006.
    • Álvarez-Lajonchere L, Dueñas Carrera S, Guerra I, Acosta-Rivero N, Musacchio A, Vázquez M, Recombinant live fowlpox virus vectors and their use in pharmaceutical compositions against hepatitis C virus. WO/2006/015557, 2006.
  • 27
    • 53549133140 scopus 로고    scopus 로고
    • Immunization with a recombinant fowl pox virus expressing a hepatitis C virus Core-E1 polyprotein variant protects mice and monkeys against challenge with a surrogate vaccinia virus
    • In press
    • Álvarez-Lajonchere L, Amador-Cañizares Y, Frías R, Milian Y, Musacchio A, Guerra I et al. Immunization with a recombinant fowl pox virus expressing a hepatitis C virus Core-E1 polyprotein variant protects mice and monkeys against challenge with a surrogate vaccinia virus. Biotechnology and Applied Biochemistry. In press, 2008.
    • (2008) Biotechnology and Applied Biochemistry
    • Álvarez-Lajonchere, L.1    Amador-Cañizares, Y.2    Frías, R.3    Milian, Y.4    Musacchio, A.5    Guerra, I.6
  • 28
    • 0016367406 scopus 로고
    • The isolation of simian virus 40 variants with specifically altered genomes
    • Brockman WW, Nathans D. The isolation of simian virus 40 variants with specifically altered genomes. Proc Natl Acad Sci USA (1974);71:942-6.
    • (1974) Proc Natl Acad Sci USA , vol.71 , pp. 942-946
    • Brockman, W.W.1    Nathans, D.2
  • 29
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970); 227: 680-5.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 30
    • 0009482260 scopus 로고
    • Electrophoretic transfer of proteins from polyacrylamides gels to nitrocellulose sheets: Procedure and some applications
    • Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamides gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA (1981); 769:4350-4.
    • (1981) Proc Natl Acad Sci USA , vol.769 , pp. 4350-4354
    • Towbin, H.1    Staehelin, T.2    Gordon, J.3
  • 31
    • 0033133933 scopus 로고    scopus 로고
    • Ultrastructural and immunocytochemical evidences of core-particle formation in the methylotrophic Pichia pastoris yeast when expressing HCV structural proteins (core-E1)
    • Falcon V, García C, de la Rosa MC, Menéndez I, Seoane J, Grillo JM. Ultrastructural and immunocytochemical evidences of core-particle formation in the methylotrophic Pichia pastoris yeast when expressing HCV structural proteins (core-E1). Tissue Cell (1999);31:117-125.
    • (1999) Tissue Cell , vol.31 , pp. 117-125
    • Falcon, V.1    García, C.2    de la Rosa, M.C.3    Menéndez, I.4    Seoane, J.5    Grillo, J.M.6
  • 35
    • 0031774156 scopus 로고    scopus 로고
    • The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix
    • Vázquez MI, Rivas G, Cregut D, Serrano L, Esteban M. The vaccinia virus 14-kilodalton (A27L) fusion protein forms a triple coiled-coil structure and interacts with the 21-kilodalton (A17L) virus membrane protein through a C-terminal alpha-helix. J Virol (1998); 72:10126-37.
    • (1998) J Virol , vol.72 , pp. 10126-10137
    • Vázquez, M.I.1    Rivas, G.2    Cregut, D.3    Serrano, L.4    Esteban, M.5
  • 36
    • 0033573545 scopus 로고    scopus 로고
    • Recombinat vaccinia viruses: Design, Generation an Isolation
    • Broder CC and Earl P. Recombinat vaccinia viruses: Design, Generation an Isolation. Molecular Biotechnology (1999); 13:223-45.
    • (1999) Molecular Biotechnology , vol.13 , pp. 223-245
    • Broder, C.C.1    Earl, P.2
  • 37
    • 20844436465 scopus 로고    scopus 로고
    • Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus
    • Chan KS, Verardi PH, Legrand FA, Yilma TD. Nef from pathogenic simian immunodeficiency virus is a negative factor for vaccinia virus. Proc Natl Acad Sci USA (2005); 102:8734-9.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 8734-8739
    • Chan, K.S.1    Verardi, P.H.2    Legrand, F.A.3    Yilma, T.D.4
  • 38
    • 0037974714 scopus 로고    scopus 로고
    • Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection
    • Murata K, Lechmann M, Qiao M, Gunji T, Alter HJ, and Liang TJ. Immunization with hepatitis C virus-like particles protects mice from recombinant hepatitis C virus-vaccinia infection. Proc Natl Acad Sci USA (2003); 100:6753-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 6753-6758
    • Murata, K.1    Lechmann, M.2    Qiao, M.3    Gunji, T.4    Alter, H.J.5    Liang, T.J.6
  • 39
    • 0037413979 scopus 로고    scopus 로고
    • Enhanced induction of hepatitis C virus-specific cytotoxic T lymphocytes and protective efficacy in mice by DNA vaccination followed by adenovirus boosting in combination with the interleukin-12 expression plasmid
    • Matsui M, Moriya O, Akatsuka T. Enhanced induction of hepatitis C virus-specific cytotoxic T lymphocytes and protective efficacy in mice by DNA vaccination followed by adenovirus boosting in combination with the interleukin-12 expression plasmid. Vaccine (2003); 21:1629-39.
    • (2003) Vaccine , vol.21 , pp. 1629-1639
    • Matsui, M.1    Moriya, O.2    Akatsuka, T.3
  • 40
    • 0033556262 scopus 로고    scopus 로고
    • Suppression of Host Immune Response by the Core Protein of hepatitis C Virus: Possible Implications for hepatitis C Virus Persistence
    • Large MK, Kittlesen DJ, Hahn YS. Suppression of Host Immune Response by the Core Protein of hepatitis C Virus: Possible Implications for hepatitis C Virus Persistence. J Immunol (1999); 162:931-8.
    • (1999) J Immunol , vol.162 , pp. 931-938
    • Large, M.K.1    Kittlesen, D.J.2    Hahn, Y.S.3
  • 41
    • 0026052846 scopus 로고
    • Antiviral protection by CD8+versus CD4+T cells. CD8+T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL
    • Binder D, Küding TM. Antiviral protection by CD8+versus CD4+T cells. CD8+T cells correlating with cytotoxic activity in vitro are more efficient in antivaccinia virus protection than CD4-dependent IL. J Immunol (1991); 146:4301-7.
    • (1991) J Immunol , vol.146 , pp. 4301-4307
    • Binder, D.1    Küding, T.M.2
  • 42
    • 3242664243 scopus 로고    scopus 로고
    • Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression
    • Kronenberger B, Sarrazin C, Hofmann WP, von Wagner M, Herrmann E, Welsch C et al. Mutations in the putative HCV-E2 CD81 binding regions and correlation with cell surface CD81 expression. J Viral Hepat (2004); 11:310-8.
    • (2004) J Viral Hepat , vol.11 , pp. 310-318
    • Kronenberger, B.1    Sarrazin, C.2    Hofmann, W.P.3    von Wagner, M.4    Herrmann, E.5    Welsch, C.6
  • 43
    • 0038649813 scopus 로고    scopus 로고
    • Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b
    • Saito T, Ito T, Ishiko H, Yonaha M, Morikawa K, Miyokawa A et al. Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b. Am J Gastroenterol (2003); 98: 1377-83.
    • (2003) Am J Gastroenterol , vol.98 , pp. 1377-1383
    • Saito, T.1    Ito, T.2    Ishiko, H.3    Yonaha, M.4    Morikawa, K.5    Miyokawa, A.6
  • 44
    • 0042412234 scopus 로고    scopus 로고
    • Lethality in mice infected with recombinant vaccinia virus expressing hepatitis C virus core protein
    • Zhang H. Lethality in mice infected with recombinant vaccinia virus expressing hepatitis C virus core protein. Hepatobiliary Pancreat Dis Int (2003); 2:374-82.
    • (2003) Hepatobiliary Pancreat Dis Int , vol.2 , pp. 374-382
    • Zhang, H.1
  • 45
    • 0028356759 scopus 로고
    • An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans
    • Shirai M, Okada H, Nishioka M, Akatsuka T, Wychowski C, Houghten R et al. An epitope in hepatitis C virus core region recognized by cytotoxic T cells in mice and humans. J Virol (1994); 68:3334-42.
    • (1994) J Virol , vol.68 , pp. 3334-3342
    • Shirai, M.1    Okada, H.2    Nishioka, M.3    Akatsuka, T.4    Wychowski, C.5    Houghten, R.6
  • 46
    • 0030068733 scopus 로고    scopus 로고
    • Use of intrinsic and extrinsic helper epitopes for in vivo induction of anti-hepatitis C virus cytotoxic T lymphocytes (CTL) with CTL epitope peptide vaccines
    • Shirai M, Chen M, Arichi T, Masaki T, Nishioka M, Newman M et al. Use of intrinsic and extrinsic helper epitopes for in vivo induction of anti-hepatitis C virus cytotoxic T lymphocytes (CTL) with CTL epitope peptide vaccines. J Infect Dis (1996); 173:24-31.
    • (1996) J Infect Dis , vol.173 , pp. 24-31
    • Shirai, M.1    Chen, M.2    Arichi, T.3    Masaki, T.4    Nishioka, M.5    Newman, M.6
  • 47
    • 0033976573 scopus 로고    scopus 로고
    • Characterization of Specific Immune Responses of Mice Inoculated with Recombinant Vaccinia Virus Expressing an 18-Kilodalton Outer Membrane Protein of Brucella abortus
    • Vemulapalli R, Cravero S, Calvert CL, Toth TE, Sriranganathan N, Boyle SM et al. Characterization of Specific Immune Responses of Mice Inoculated with Recombinant Vaccinia Virus Expressing an 18-Kilodalton Outer Membrane Protein of Brucella abortus. Clin Diagn Lab Immunol (2000); 7:114-8.
    • (2000) Clin Diagn Lab Immunol , vol.7 , pp. 114-118
    • Vemulapalli, R.1    Cravero, S.2    Calvert, C.L.3    Toth, T.E.4    Sriranganathan, N.5    Boyle, S.M.6
  • 48
    • 0036118394 scopus 로고    scopus 로고
    • Recombinant Vaccinia Virus-Induced T-Cell Immunity: Quantitation of the Response to the Virus Vector and the Foreign Epitope
    • Harrington LE, van der Most R, Whitton JL, and Ahmed R. Recombinant Vaccinia Virus-Induced T-Cell Immunity: Quantitation of the Response to the Virus Vector and the Foreign Epitope. J Virol (2002); 76:3329-37.
    • (2002) J Virol , vol.76 , pp. 3329-3337
    • Harrington, L.E.1    van der Most, R.2    Whitton, J.L.3    Ahmed, R.4
  • 49
    • 23944485662 scopus 로고    scopus 로고
    • Evasion of intracellular host defence by hepatitis C virus
    • Gale M Jr, Foy EM. Evasion of intracellular host defence by hepatitis C virus. Nature (2005); 436:939-45.
    • (2005) Nature , vol.436 , pp. 939-945
    • Gale Jr, M.1    Foy, E.M.2
  • 51
    • 0036144586 scopus 로고    scopus 로고
    • hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity
    • Liu ZX, Nishida H, He JW, Lai MM, Feng N, Dennert G. hepatitis C virus genotype 1b core protein does not exert immunomodulatory effects on virus-induced cellular immunity. J Virol (2002); 76:990-6.
    • (2002) J Virol , vol.76 , pp. 990-996
    • Liu, Z.X.1    Nishida, H.2    He, J.W.3    Lai, M.M.4    Feng, N.5    Dennert, G.6
  • 52
    • 0035988241 scopus 로고    scopus 로고
    • In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus
    • Hunziker IP, Grabscheid B, Zurbriggen R, Gluck R, Pichler WJ, Cerny A. In vitro studies of core peptide-bearing immunopotentiating reconstituted influenza virosomes as a non-live prototype vaccine against hepatitis C virus. Int Immunol (2002); 14:615-26.
    • (2002) Int Immunol , vol.14 , pp. 615-626
    • Hunziker, I.P.1    Grabscheid, B.2    Zurbriggen, R.3    Gluck, R.4    Pichler, W.J.5    Cerny, A.6


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